    <SEC-DOCUMENT>0001104659-23-049982-index.html : 20230426
    <SEC-HEADER>0001104659-23-049982.hdr.sgml : 20230426
    <ACCEPTANCE-DATETIME>20230426090451
    ACCESSION NUMBER:		0001104659-23-049982
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20221231
    FILED AS OF DATE:		20230426
    DATE AS OF CHANGE:		20230426
    EFFECTIVENESS DATE:		20230426

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			EXACT SCIENCES CORP
    		CENTRAL INDEX KEY:			0001124140
    		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
    		IRS NUMBER:				204782291
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-35092
    		FILM NUMBER:		23847009

    	BUSINESS ADDRESS:
    		STREET 1:		5505 ENDEAVOR LANE
    		CITY:			MADISON
    		STATE:			WI
    		ZIP:			53719
    		BUSINESS PHONE:		608-284-5700

    	MAIL ADDRESS:
    		STREET 1:		5505 ENDEAVOR LANE
    		CITY:			MADISON
    		STATE:			WI
    		ZIP:			53719

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	EXACT CORP
    		DATE OF NAME CHANGE:	20000919
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>tm2312009d1_ars.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: tm2312009d1_ars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>