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Condensed Consolidated Statements of Redeemable Convertible Noncontrolling Interests and Stockholders' Equity - USD ($) $ in Thousands | Total | Cumulative Effect, Period of Adoption, Adjusted Balance | Equity Compensation Plans | Employee Stock Purchase Plan | Satisfy Tax Withholding | Redeemable Convertible Noncontrolling Interests | Common Stock | Common Stock Equity Compensation Plans | Common Stock 2020 Stock and Equity Exchange Program | Common Stock Employee Stock Purchase Plan | Common Stock Satisfy Tax Withholding | Treasury Stock | Additional Paid-in Capital | Additional Paid-in Capital Cumulative Effect, Period of Adoption, Adjusted Balance | Additional Paid-in Capital Equity Compensation Plans | Additional Paid-in Capital 2020 Stock and Equity Exchange Program | Additional Paid-in Capital Employee Stock Purchase Plan | Additional Paid-in Capital Satisfy Tax Withholding | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit | Accumulated Deficit Cumulative Effect, Period of Adoption, Adjusted Balance | Parent | Parent Cumulative Effect, Period of Adoption, Adjusted Balance | Parent Equity Compensation Plans | Parent 2020 Stock and Equity Exchange Program | Parent Employee Stock Purchase Plan | Parent Satisfy Tax Withholding | Noncontrolling Interests | Noncontrolling Interests 2020 Stock and Equity Exchange Program
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Beginning balance at Dec. 31, 2019 | [1] | $ 473,733 |  |  |  |  |  |  |  | $ 124 |  |  |  |  |  | $ 848,107 |  |  |  |  |  | $ 254 | $ (440,031) |  | $ 408,454 |  |  |  |  |  | $ 65,279 |
Temporary equity, beginning balance at Dec. 31, 2019 | [1] |  |  |  |  |  |  | $ 2,243 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance, shares at Dec. 31, 2019 | [1] |  |  |  |  |  |  |  |  | 123,658,287 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of shares |  |  |  |  | $ 529 |  |  |  |  |  |  |  |  |  |  |  |  | $ 529 |  |  |  |  |  |  |  |  | $ 529 |  |  |  |  |
Issuance of shares, shares |  |  |  |  |  |  |  |  |  |  | 116,249 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 8,063 |  |  |  |  |  |  |  |  |  |  |  |  |  | 8,063 |  |  |  |  |  |  |  |  | 8,063 |  |  |  |  |  |  |
Equity component of 2027 Notes, net of issuance costs and deferred tax liability |  | 167,726 |  |  |  |  |  |  |  |  |  |  |  |  |  | 167,726 |  |  |  |  |  |  |  |  | 167,726 |  |  |  |  |  |  |
Purchase of capped calls |  | (49,280) |  |  |  |  |  |  |  |  |  |  |  |  |  | (49,280) |  |  |  |  |  |  |  |  | (49,280) |  |  |  |  |  |  |
Repurchase of common stock |  | (75,000) |  |  |  |  |  |  |  |  |  |  |  |  | $ (75,000) |  |  |  |  |  |  |  |  |  | (75,000) |  |  |  |  |  |  |
Repurchase of common stock, shares |  |  |  |  |  |  |  |  |  | (2,414,681) |  |  |  |  | 2,414,681 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of noncontrolling interests |  | 26,565 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 26,565 |
Temporary Equity, issuance (repurchase) of noncontrolling interest |  |  |  |  |  |  |  | 1,102 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Transfers from (to) noncontrolling interests |  | (574) |  |  |  |  |  |  |  |  |  |  |  |  |  | 11,601 |  |  |  |  |  |  |  |  | 11,601 |  |  |  |  |  | (12,175) |
Temporary Equity, transfers from (to) noncontrolling interest |  |  |  |  |  |  |  | 574 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gains (losses) on available-for-sale securities |  | 472 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 472 |  |  | 472 |  |  |  |  |  |  |
Net loss |  | (103,216) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (91,850) |  | (91,850) |  |  |  |  |  | (11,366) |
Temporary Equity, net loss |  |  |  |  |  |  |  | (866) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Mar. 31, 2020 |  | 449,018 |  |  |  |  |  |  |  | $ 124 |  |  |  |  | $ (75,000) | 986,746 |  |  |  |  |  | 726 | (531,881) |  | 380,715 |  |  |  |  |  | 68,303 |
Temporary equity, ending balance at Mar. 31, 2020 |  |  |  |  |  |  |  | 3,053 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance, shares at Mar. 31, 2020 |  |  |  |  |  |  |  |  |  | 121,359,855 |  |  |  |  | 2,414,681 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2019 | [1] | 473,733 |  |  |  |  |  |  |  | $ 124 |  |  |  |  |  | 848,107 |  |  |  |  |  | 254 | (440,031) |  | 408,454 |  |  |  |  |  | 65,279 |
Temporary equity, beginning balance at Dec. 31, 2019 | [1] |  |  |  |  |  |  | 2,243 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance, shares at Dec. 31, 2019 | [1] |  |  |  |  |  |  |  |  | 123,658,287 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gains (losses) on available-for-sale securities |  | 207 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2020 |  | 215,813 |  |  |  |  |  |  |  | $ 125 |  |  |  |  | $ (75,000) | 1,006,944 |  |  |  |  |  | 461 | (768,774) |  | 163,756 |  |  |  |  |  | 52,057 |
Temporary equity, ending balance at Sep. 30, 2020 |  |  |  |  |  |  |  | 2,574 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance, shares at Sep. 30, 2020 |  |  |  |  |  |  |  |  |  | 122,542,410 |  |  |  |  | 2,414,681 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2020 |  | 449,018 |  |  |  |  |  |  |  | $ 124 |  |  |  |  | $ (75,000) | 986,746 |  |  |  |  |  | 726 | (531,881) |  | 380,715 |  |  |  |  |  | 68,303 |
Temporary equity, beginning balance at Mar. 31, 2020 |  |  |  |  |  |  |  | 3,053 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance, shares at Mar. 31, 2020 |  |  |  |  |  |  |  |  |  | 121,359,855 |  |  |  |  | 2,414,681 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of shares |  |  |  |  | 691 |  |  |  |  |  |  | $ 1 |  |  |  |  |  | 691 | $ 1,069 |  |  |  |  |  |  |  | 691 | $ 1,070 |  |  |  | $ (1,070)
Issuance of shares, shares |  |  |  |  |  |  |  |  |  |  | 264,583 | 626,820 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 7,295 |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,295 |  |  |  |  |  |  |  |  | 7,295 |  |  |  |  |  |  |
Issuance of noncontrolling interests |  | 3,537 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,537 |
Transfers from (to) noncontrolling interests |  | (431) |  |  |  |  |  |  |  |  |  |  |  |  |  | (3,110) |  |  |  |  |  |  |  |  | (3,110) |  |  |  |  |  | 2,679 |
Temporary Equity, transfers from (to) noncontrolling interest |  |  |  |  |  |  |  | 431 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gains (losses) on available-for-sale securities |  | 132 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 132 |  |  | 132 |  |  |  |  |  |  |
Net loss |  | (134,636) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (121,034) |  | (121,034) |  |  |  |  |  | (13,602) |
Temporary Equity, net loss |  |  |  |  |  |  |  | (1,578) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Jun. 30, 2020 |  | 325,606 |  |  |  |  |  |  |  | $ 125 |  |  |  |  | $ (75,000) | 992,691 |  |  |  |  |  | 858 | (652,915) |  | 265,759 |  |  |  |  |  | 59,847 |
Temporary equity, ending balance at Jun. 30, 2020 |  |  |  |  |  |  |  | 1,906 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance, shares at Jun. 30, 2020 |  |  |  |  |  |  |  |  |  | 122,251,258 |  |  |  |  | 2,414,681 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of shares |  |  |  |  | 462 | $ 1,205 |  |  |  |  |  |  |  |  |  |  |  | 462 |  | $ 1,205 |  |  |  |  |  |  | 462 |  | $ 1,205 |  |  |
Issuance of shares, shares |  |  |  |  |  |  |  |  |  |  | 249,971 |  | 49,696 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 11,748 |  |  |  |  |  |  |  |  |  |  |  |  |  | 11,748 |  |  |  |  |  |  |  |  | 11,748 |  |  |  |  |  |  |
Repurchase of common stock to satisfy tax withholding |  |  |  |  |  |  | $ (243) |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (243) |  |  |  |  |  |  |  |  | $ (243) |  |
Repurchase of shares to satisfy tax withholding, shares |  |  |  |  |  |  |  |  |  |  |  |  |  | (8,515) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of noncontrolling interests |  | 7,267 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,267 |
Temporary Equity, issuance (repurchase) of noncontrolling interest |  |  |  |  |  |  |  | 1,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Transfers from (to) noncontrolling interests |  | (799) |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,081 |  |  |  |  |  |  |  |  | 1,081 |  |  |  |  |  | (1,880) |
Temporary Equity, transfers from (to) noncontrolling interest |  |  |  |  |  |  |  | 799 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gains (losses) on available-for-sale securities |  | (397) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (397) |  |  | (397) |  |  |  |  |  |  |
Net loss |  | (129,036) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (115,859) |  | (115,859) |  |  |  |  |  | (13,177) |
Temporary Equity, net loss |  |  |  |  |  |  |  | (1,131) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2020 |  | 215,813 |  |  |  |  |  |  |  | $ 125 |  |  |  |  | $ (75,000) | 1,006,944 |  |  |  |  |  | 461 | (768,774) |  | 163,756 |  |  |  |  |  | 52,057 |
Temporary equity, ending balance at Sep. 30, 2020 |  |  |  |  |  |  |  | 2,574 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance, shares at Sep. 30, 2020 |  |  |  |  |  |  |  |  |  | 122,542,410 |  |  |  |  | 2,414,681 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2020 | [1] | 106,256 | [2] |  |  |  |  |  |  | $ 125 |  |  |  |  | $ (75,000) | 1,021,344 |  |  |  |  |  | 192 | (888,755) |  | 57,906 |  |  |  |  |  | 48,350 |
Beginning balance (ASU 2020 06) at Dec. 31, 2020 |  |  |  | $ (153,750) |  |  |  |  |  |  |  |  |  |  |  |  | $ (168,078) |  |  |  |  |  |  | $ 14,328 |  | $ (153,750) |  |  |  |  |  |
Temporary equity, beginning balance at Dec. 31, 2020 |  | 1,630 | [2] |  |  |  |  | 1,630 | [1] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance, shares at Dec. 31, 2020 | [1] |  |  |  |  |  |  |  |  | 122,849,389 |  |  |  |  | 2,414,681 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of shares |  |  |  |  | 6,842 | 1,651 |  |  |  |  | $ 1 |  |  |  |  |  |  | 6,841 |  | 1,651 |  |  |  |  |  |  | 6,842 |  | 1,651 |  |  |
Issuance of shares, shares |  |  |  |  |  |  |  |  |  |  | 819,113 |  | 65,298 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 19,841 |  |  |  |  |  |  |  |  |  |  |  |  |  | 19,841 |  |  |  |  |  |  |  |  | 19,841 |  |  |  |  |  |  |
Purchase of capped calls |  | (61,295) |  |  |  |  |  |  |  |  |  |  |  |  |  | (61,295) |  |  |  |  |  |  |  |  | (61,295) |  |  |  |  |  |  |
Repurchase of common stock |  | (50,000) |  |  |  |  |  |  |  |  |  |  |  |  | $ (50,000) |  |  |  |  |  |  |  |  |  | (50,000) |  |  |  |  |  |  |
Repurchase of common stock, shares |  |  |  |  |  |  |  |  |  | (759,993) |  |  |  |  | 759,993 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Repurchase of common stock to satisfy tax withholding |  |  |  |  |  |  | (1,021) |  |  |  |  |  |  |  |  |  |  |  |  |  | (1,021) |  |  |  |  |  |  |  |  | (1,021) |  |
Repurchase of shares to satisfy tax withholding, shares |  |  |  |  |  |  |  |  |  |  |  |  |  | (15,653) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Repurchase of Eidos noncontrolling interests for cash and shares, including transaction costs of $70,734 |  | (91,997) |  |  |  |  |  |  |  | $ 26 |  |  |  |  |  | (53,856) |  |  |  |  |  |  |  |  | (53,830) |  |  |  |  |  | (38,167) |
Repurchase of noncontrolling interests for cash and shares, including transaction costs shares |  |  |  |  |  |  |  |  |  | 26,156,446 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of noncontrolling interests |  | 5,080 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,080 |
Transfers from (to) noncontrolling interests |  | (517) |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,690 |  |  |  |  |  |  |  |  | 1,690 |  |  |  |  |  | (2,207) |
Temporary Equity, transfers from (to) noncontrolling interest |  |  |  |  |  |  |  | 517 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gains (losses) on available-for-sale securities |  | (249) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (249) |  |  | (249) |  |  |  |  |  |  |
Net loss |  | (170,206) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (163,079) |  | (163,079) |  |  |  |  |  | (7,127) |
Temporary Equity, net loss |  |  |  |  |  |  |  | (876) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Mar. 31, 2021 |  | (389,365) |  |  |  |  |  |  |  | $ 152 |  |  |  |  | $ (125,000) | 767,117 |  |  |  |  |  | (57) | (1,037,506) |  | (395,294) |  |  |  |  |  | 5,929 |
Temporary equity, ending balance at Mar. 31, 2021 |  |  |  |  |  |  |  | 1,271 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance, shares at Mar. 31, 2021 |  |  |  |  |  |  |  |  |  | 149,114,600 |  |  |  |  | 3,174,674 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2020 | [1] | 106,256 | [2] |  |  |  |  |  |  | $ 125 |  |  |  |  | $ (75,000) | 1,021,344 |  |  |  |  |  | 192 | (888,755) |  | 57,906 |  |  |  |  |  | 48,350 |
Beginning balance (ASU 2020 06) at Dec. 31, 2020 |  |  |  | $ (153,750) |  |  |  |  |  |  |  |  |  |  |  |  | $ (168,078) |  |  |  |  |  |  | $ 14,328 |  | $ (153,750) |  |  |  |  |  |
Temporary equity, beginning balance at Dec. 31, 2020 |  | 1,630 | [2] |  |  |  |  | 1,630 | [1] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance, shares at Dec. 31, 2020 | [1] |  |  |  |  |  |  |  |  | 122,849,389 |  |  |  |  | 2,414,681 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gains (losses) on available-for-sale securities |  | (173) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2021 |  | (738,841) |  |  |  |  |  |  |  | $ 153 |  |  |  |  | $ (275,000) | 821,220 |  |  |  |  |  | 19 | (1,289,789) |  | (743,397) |  |  |  |  |  | 4,556 |
Temporary equity, ending balance at Sep. 30, 2021 |  | 2,967 |  |  |  |  |  | 2,967 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance, shares at Sep. 30, 2021 |  |  |  |  |  |  |  |  |  | 147,087,891 |  |  |  |  | 6,191,761 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2021 |  | (389,365) |  |  |  |  |  |  |  | $ 152 |  |  |  |  | $ (125,000) | 767,117 |  |  |  |  |  | (57) | (1,037,506) |  | (395,294) |  |  |  |  |  | 5,929 |
Temporary equity, beginning balance at Mar. 31, 2021 |  |  |  |  |  |  |  | 1,271 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance, shares at Mar. 31, 2021 |  |  |  |  |  |  |  |  |  | 149,114,600 |  |  |  |  | 3,174,674 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of shares |  |  |  |  | 3,751 |  |  |  |  |  | $ 1 |  |  |  |  |  |  | 3,750 |  |  |  |  |  |  |  |  | 3,751 |  |  |  |  |
Issuance of shares, shares |  |  |  |  |  |  |  |  |  |  | 646,250 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 32,509 |  |  |  |  |  |  |  |  |  |  |  |  |  | 32,509 |  |  |  |  |  |  |  |  | 32,509 |  |  |  |  |  |  |
Repurchase of common stock |  | (5,308) |  |  |  |  |  |  |  |  |  |  |  |  | $ (5,308) |  |  |  |  |  |  |  |  |  | (5,308) |  |  |  |  |  |  |
Repurchase of common stock, shares |  |  |  |  |  |  |  |  |  | (104,694) |  |  |  |  | (104,694) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Repurchase of common stock to satisfy tax withholding |  |  |  |  |  |  | $ (2,281) |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (2,281) |  |  |  |  |  |  |  |  | $ (2,281) |  |
Repurchase of shares to satisfy tax withholding, shares |  |  |  |  |  |  |  |  |  |  |  |  |  | (41,416) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of PellePharm noncontrolling interest on consolidation |  |  |  |  |  |  |  | 5,074 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of noncontrolling interests |  | 5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 |
Temporary Equity, issuance (repurchase) of noncontrolling interest |  |  |  |  |  |  |  | 700 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Transfers from (to) noncontrolling interests |  | 3,618 |  |  |  |  |  |  |  |  |  |  |  |  |  | (1,416) |  |  |  |  |  |  |  |  | (1,416) |  |  |  |  |  | 5,034 |
Temporary Equity, transfers from (to) noncontrolling interest |  |  |  |  |  |  |  | (3,618) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gains (losses) on available-for-sale securities |  | 93 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 93 |  |  | 93 |  |  |  |  |  |  |
Net loss |  | (100,512) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (96,348) |  | (96,348) |  |  |  |  |  | (4,164) |
Temporary Equity, net loss |  |  |  |  |  |  |  | (1,562) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Jun. 30, 2021 |  | (457,490) |  |  |  |  |  |  |  | $ 153 |  |  |  |  | $ (130,308) | 799,679 |  |  |  |  |  | 36 | (1,133,854) |  | (464,294) |  |  |  |  |  | 6,804 |
Temporary equity, ending balance at Jun. 30, 2021 |  |  |  |  |  |  |  | 1,865 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance, shares at Jun. 30, 2021 |  |  |  |  |  |  |  |  |  | 149,614,740 |  |  |  |  | 3,279,368 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of shares |  |  |  |  | $ 3,704 | $ 2,170 |  |  |  |  |  |  |  |  |  |  |  | $ 3,704 |  | $ 2,170 |  |  |  |  |  |  | $ 3,704 |  | $ 2,170 |  |  |
Issuance of shares, shares |  |  |  |  |  |  |  |  |  |  | 349,452 |  | 50,924 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 16,896 |  |  |  |  |  |  |  |  |  |  |  |  |  | 16,896 |  |  |  |  |  |  |  |  | 16,896 |  |  |  |  |  |  |
Repurchase of common stock |  | (144,692) |  |  |  |  |  |  |  |  |  |  |  |  | $ (144,692) |  |  |  |  |  |  |  |  |  | (144,692) |  |  |  |  |  |  |
Repurchase of common stock, shares |  |  |  |  |  |  |  |  |  | (2,912,393) |  |  |  |  | 2,912,393 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Repurchase of common stock to satisfy tax withholding |  | (734) |  |  |  |  |  |  |  |  |  |  |  |  |  | (734) |  |  |  |  |  |  |  |  | (734) |  |  |  |  |  |  |
Repurchase of shares to satisfy tax withholding, shares |  |  |  |  |  |  |  |  |  | (14,832) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of noncontrolling interests |  | 640 |  |  |  |  |  | 2,800 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 640 |
Transfers from (to) noncontrolling interests |  | 362 |  |  |  |  |  | (362) |  |  |  |  |  |  |  | (495) |  |  |  |  |  |  |  |  | (495) |  |  |  |  |  | 857 |
Unrealized gains (losses) on available-for-sale securities |  | (17) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (17) |  |  | (17) |  |  |  |  |  |  |
Net loss |  | (159,680) |  |  |  |  |  | (1,336) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (155,935) |  | (155,935) |  |  |  |  |  | (3,745) |
Ending balance at Sep. 30, 2021 |  | (738,841) |  |  |  |  |  |  |  | $ 153 |  |  |  |  | $ (275,000) | $ 821,220 |  |  |  |  |  | $ 19 | $ (1,289,789) |  | $ (743,397) |  |  |  |  |  | $ 4,556 |
Temporary equity, ending balance at Sep. 30, 2021 |  | $ 2,967 |  |  |  |  |  | $ 2,967 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance, shares at Sep. 30, 2021 |  |  |  |  |  |  |  |  |  | 147,087,891 |  |  |  |  | 6,191,761 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
[1] | The consolidated balances as of December 31, 2020 and 2019 are derived from the audited consolidated financial statements as of those dates.
[2] | The condensed consolidated balance sheet as of December 31, 2020 is derived from the audited consolidated financial statements as of that date.

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- Definition Carrying amount, attributable to parent and noncontrolling interests, of an entity's issued and outstanding stock which is not included within permanent equity. Temporary equity is a security with redemption features that are outside the control of the issuer, is not classified as an asset or liability in conformity with GAAP, and is not mandatorily redeemable. Includes any type of security that is redeemable at a fixed or determinable price or on a fixed or determinable date or dates, is redeemable at the option of the holder, or has conditions for redemption which are not solely within the control of the issuer. Includes stock with a put option held by an ESOP and stock redeemable by a holder only in the event of a change in control of the issuer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.27(b)) -URI http://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(g)(1)(ii)) -URI http://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 28 -Subparagraph (f) -URI http://asc.fasb.org/extlink&oid=75031198&loc=d3e14064-108612 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 323 -SubTopic 10 -Section 50 -Paragraph 3 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=114001798&loc=d3e33918-111571 + Details
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