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Net Loss Per Share | 6 Months Ended
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Jun. 30, 2022
Earnings Per Share [Abstract] |
Net Loss Per Share | 18. Net Loss Per Share The following common stock equivalents were excluded from the computation of diluted net loss per share, because including them would have been antidilutive:
| As of June 30, |  |
| 2022 |  |  | 2021 |  |
Unvested RSAs |  | 1,114,006 |  |  |  | 2,468,416 |  |
Unvested RSUs |  | 6,055,931 |  |  |  | 1,643,312 |  |
Unvested performance-based RSUs |  | 84,505 |  |  |  | 66,683 |  |
Common stock options issued and outstanding |  | 12,669,110 |  |  |  | 10,320,564 |  |
Estimated shares issuable under performance-based milestone compensation arrangements |  | 29,396,554 |  |  |  | 3,785,559 |  |
Estimated shares issuable under the ESPP |  | 207,960 |  |  |  | 37,649 |  |
Assumed conversion of 2027 Notes |  | 12,878,305 |  |  |  | 12,878,305 |  |
Assumed conversion of 2029 Notes |  | 7,702,988 |  |  |  | 7,702,988 |  |
|  | 70,109,359 |  |  |  | 38,903,476 |  |
Our 2029 Notes and 2027 Notes are convertible, based on the applicable conversion rate, into cash, shares of our common stock or a combination thereof, at our election. As discussed in Notes 9 and 15, we have performance-based milestone compensation arrangements, whose vesting is contingent upon meeting various regulatory and development milestones, with fixed monetary amounts known at inception that can be settled in the form of cash or equity at our sole election, upon achievement of each contingent milestone. The common stock equivalents of such arrangements were estimated as if the contingent milestones were achieved as of the reporting date and the arrangements were all settled in equity.

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