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Restructuring, Impairment and Related Charges - Schedule of Activity Related to Restructuring Liabilities Associated to Restructuring Initiatives (Details) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2023 | Mar. 31, 2022
Restructuring Cost and Reserve [Line Items] |  |
Restructuring liabilities, balance | $ 6,826 | $ 0
Reclassification of final payment obligation related to a manufacturing agreement that was recognized in the prior period (see Note 13) | 0 | 2,185
Restructuring, impairment and related charges | 3,369 | 22,662
Cash payments | (8,905) | (3,867)
Noncash activities | 0 | (13,825)
Restructuring liabilities, balance | 1,290 | $ 7,155
Accounts Payable |  |
Restructuring Cost and Reserve [Line Items] |  |
Restructuring liabilities, balance | 896 |
Restructuring liabilities, balance | 98 |
Accrued Compensation and Benefits |  |
Restructuring Cost and Reserve [Line Items] |  |
Restructuring liabilities, balance | 41 |
Restructuring liabilities, balance | 143 |
Accrued Research and Development Liabilities |  |
Restructuring Cost and Reserve [Line Items] |  |
Restructuring liabilities, balance | 5,889 |
Restructuring liabilities, balance | $ 1,049 |

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- Definition Amount of cash payments made as the result of exit or disposal activities. Excludes payments associated with a discontinued operation or an asset retirement obligation. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b)(2) -URI https://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 17 -Subparagraph (f) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3367-108585 + Details
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- Definition Carrying amount as of the balance sheet date of known and estimated obligations associated with exit from or disposal of business activities or restructurings pursuant to a duly authorized plan, which are expected to be paid in the next twelve months or in the normal operating cycle if longer. Costs of such activities include those for one-time termination benefits, termination of an operating lease or other contract, consolidating or closing facilities, relocating employees, and costs associated with an ongoing benefit arrangement, but excludes costs associated with the retirement of a long-lived asset. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(20)) -URI https://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SAB Topic 5.P.4(b)(2)) -URI https://asc.fasb.org/extlink&oid=115931487&loc=d3e140904-122747 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b)(2) -URI https://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869 + Details
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