    <SEC-DOCUMENT>0001047469-17-007712-index.html : 20171218
    <SEC-HEADER>0001047469-17-007712.hdr.sgml : 20171218
    <ACCEPTANCE-DATETIME>20171218070908
    ACCESSION NUMBER:		0001047469-17-007712
    CONFORMED SUBMISSION TYPE:	424B5
    PUBLIC DOCUMENT COUNT:		7
    FILED AS OF DATE:		20171218
    DATE AS OF CHANGE:		20171218

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			MADRIGAL PHARMACEUTICALS, INC.
    		CENTRAL INDEX KEY:			0001157601
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B5
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-206135
    		FILM NUMBER:		171260306

    	BUSINESS ADDRESS:
    		STREET 1:		200 BARR HARBOR DRIVE, SUITE 400
    		CITY:			WEST CONSHOHOCKEN
    		STATE:			PA
    		ZIP:			19428
    		BUSINESS PHONE:		404-380-9263

    	MAIL ADDRESS:
    		STREET 1:		200 BARR HARBOR DRIVE, SUITE 400
    		CITY:			WEST CONSHOHOCKEN
    		STATE:			PA
    		ZIP:			19428

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	SYNTA PHARMACEUTICALS CORP
    		DATE OF NAME CHANGE:	20010815
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B5
    <SEQUENCE>1
    <FILENAME>a2234065z424b5.htm
    <DESCRIPTION>424B5
    <TEXT>
    Document 1 - file: a2234065z424b5.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>g467069.jpg
    <DESCRIPTION>G467069.JPG
    <TEXT>
    Document 2 - file: g467069.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>g819290.jpg
    <DESCRIPTION>G819290.JPG
    <TEXT>
    Document 3 - file: g819290.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>g343675.jpg
    <DESCRIPTION>G343675.JPG
    <TEXT>
    Document 4 - file: g343675.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>g72021.jpg
    <DESCRIPTION>G72021.JPG
    <TEXT>
    Document 5 - file: g72021.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>g837899.jpg
    <DESCRIPTION>G837899.JPG
    <TEXT>
    Document 6 - file: g837899.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>g715173.jpg
    <DESCRIPTION>G715173.JPG
    <TEXT>
    Document 7 - file: g715173.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>