<SEC-DOCUMENT>0001047469-17-007756-index.html : 20171220
<SEC-HEADER>0001047469-17-007756.hdr.sgml : 20171220
<ACCEPTANCE-DATETIME>20171219204727
ACCESSION NUMBER:		0001047469-17-007756
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20171220
DATE AS OF CHANGE:		20171219

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MADRIGAL PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001157601
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-206135
		FILM NUMBER:		171265554

	BUSINESS ADDRESS:	
		STREET 1:		200 BARR HARBOR DRIVE, SUITE 400
		CITY:			WEST CONSHOHOCKEN
		STATE:			PA
		ZIP:			19428
		BUSINESS PHONE:		404-380-9263

	MAIL ADDRESS:	
		STREET 1:		200 BARR HARBOR DRIVE, SUITE 400
		CITY:			WEST CONSHOHOCKEN
		STATE:			PA
		ZIP:			19428

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SYNTA PHARMACEUTICALS CORP
		DATE OF NAME CHANGE:	20010815
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>a2234106z424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: a2234106z424b5.htm

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<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g467069.jpg
<DESCRIPTION>G467069.JPG
<TEXT>
Document 2 - file: g467069.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g819290.jpg
<DESCRIPTION>G819290.JPG
<TEXT>
Document 3 - file: g819290.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g343675.jpg
<DESCRIPTION>G343675.JPG
<TEXT>
Document 4 - file: g343675.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g72021.jpg
<DESCRIPTION>G72021.JPG
<TEXT>
Document 5 - file: g72021.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g837899.jpg
<DESCRIPTION>G837899.JPG
<TEXT>
Document 6 - file: g837899.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>g715173.jpg
<DESCRIPTION>G715173.JPG
<TEXT>
Document 7 - file: g715173.jpg

</DOCUMENT>
</SEC-DOCUMENT>