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Stock-based Compensation (Tables)

9 Months Ended

Sep. 30, 2018

Stock-based Compensation

Summary of stock option activity

				Weighted
				average
				exercise
		Shares		price
Outstanding at January 1, 2018		976,777		$	11.97
Options granted		241,650			173.23
Options exercised		(86,095)			22.06
Options canceled		(8,750)			113.81
Outstanding at September 30, 2018		1,123,582		$	45.09
Exercisable at September 30, 2018		621,000		$	10.75

Summary of unvested restricted share activity

				Weighted
				average
				exercise
		Shares		price
Outstanding at January 1, 2018		104,127		$	9.45
Granted		—			—
Vested		(52,064)			9.45
Forfeited		—			—
Outstanding at September 30, 2018		52,063		$	9.45

Schedule of stock-based compensation expense

Stock-based compensation expense during the three and nine months ended September 2018 and 2017 was as follows (in thousands):

		Three Months Ended September 30,						Nine Months Ended September 30,
		2018			2017			2018			2017
Stock-based compensation expense by type of award:
Stock options		$	4,852		$	878		$	8,002		$	1,859
Restricted stock			124			151			368			448
Total stock-based compensation expense		$	4,976		$	1,029		$	8,370		$	2,307
Effect of stock-based compensation expense by line item:
Research and development		$	1,179		$	272		$	2,287		$	577
General and administrative			3,797			757			6,083			1,730
Total stock-based compensation expense included in net loss		$	4,976		$	1,029		$	8,370		$	2,307

Schedule of unrecognized stock-based compensation expense

Unrecognized stock-based compensation expense as of September 30, 2018 was as follows (in thousands):

					Weighted
		Unrecognized			average
		stock			remaining
		compensation			period
		expense			(in years)
Stock options		$	25,250		2.23
Restricted stock			396		0.80
Total		$	25,646		2.21

X

- Definition

Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the income statement for the period. This may include the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits. It includes the reporting line for the costs expensed.

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Tabular disclosure of the changes in outstanding nonvested restricted stock units.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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