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Stock-based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Stock-based compensation expense
Stock-based compensation expense	$ 4,976	$ 1,029	$ 8,370	$ 2,307
Research and development
Stock-based compensation expense
Stock-based compensation expense	1,179	272	2,287	577
General and administrative
Stock-based compensation expense
Stock-based compensation expense	3,797	757	6,083	1,730
Stock options
Stock-based compensation expense
Stock-based compensation expense	4,852	878	8,002	1,859
Unvested Restricted Common Stock
Stock-based compensation expense
Stock-based compensation expense	$ 124	$ 151	$ 368	$ 448

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- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
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-URI http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809

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-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901

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- Definition

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+ References

No definition available.

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