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Stock-based Compensation (Tables)
 6 Months Ended
Jun. 30, 2023
Share-based Payment Arrangement [Abstract]  
Summary of stock option activity
The following table summarizes stock option activity during the six months ended June 30, 2023:
 
    
Shares
     
Weighted
average exercise
price
  
Outstanding at January 1, 2023
      2,857,054      $ 81.78  
Options granted
      5,205        283.08  
Options exercised
      (270,609 )       89.26  
Options cancelled
      (8,110 )       84.12  
    
 
 
     
 
 
  
Outstanding at June 30, 2023
      2,583,540      $ 81.40  
    
 
 
     
 
 
  
Exercisable at June 30, 2023
      1,719,944      $ 76.62  
Schedule of stock-based compensation expense
Stock-based compensation expense during the six months ended June 30, 2023 and 2022 was as follows (in thousands):
 
    
Three Months Ended June 30,
     
Six Months Ended June 30,
  
    
2023
     
2022
     
2023
     
2022
  
Stock-based compensation expense by type of award:
                                    
Stock options
    $ 7,431      $ 7,944      $ 16,029      $ 15,421  
Restricted stock units
      3,542        —          6,194        —    
    
 
 
     
 
 
     
 
 
     
 
 
  
Total stock-based compensation expense
    $ 10,973      $ 7,944      $ 22,223      $ 15,421  
    
 
 
     
 
 
     
 
 
     
 
 
  
Effect of stock-based compensation expense by line item:
                                    
Research and development
    $ 5,184      $ 3,301      $ 10,570      $ 6,488  
General and administrative
      5,789        4,643        11,653        8,933  
    
 
 
     
 
 
     
 
 
     
 
 
  
Total stock-based compensation expense included in net loss
    $ 10,973      $ 7,944      $ 22,223      $ 15,421