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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY - USD ($) $ in Thousands | Total | Related Party | Preferred stock | Common stock | Common stock Related Party | Additional paid-in Capital | Additional paid-in Capital Related Party | Accumulated other comprehensive income (loss) | Accumulated deficit
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2022 |  |  | 2,369,797 | 18,102,523 |  |  |  |  |
Balance at Dec. 31, 2022 | $ 197,389 |  | $ 0 | $ 2 |  | $ 1,160,079 |  | $ (32) | $ (962,660)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs (in shares) |  |  |  |  | 180,551 |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs |  | $ 17,903 |  |  |  |  | $ 17,903 |  |
Stock-based compensation expense related to equity-classified awards and Compensation expense related to stock options for services | 11,250 |  |  |  |  | 11,250 |  |  |
Unrealized (loss) gain on marketable securities | (54) |  |  |  |  |  |  | (54) |
Hercules warrant | 544 |  |  |  |  | 544 |  |  |
Net loss | (76,896) |  |  |  |  |  |  |  | (76,896)
Balance (in shares) at Mar. 31, 2023 |  |  | 2,369,797 | 18,283,074 |  |  |  |  |
Balance at Mar. 31, 2023 | 150,136 |  | $ 0 | $ 2 |  | 1,189,776 |  | (86) | (1,039,556)
Balance (in shares) at Dec. 31, 2022 |  |  | 2,369,797 | 18,102,523 |  |  |  |  |
Balance at Dec. 31, 2022 | 197,389 |  | $ 0 | $ 2 |  | 1,160,079 |  | (32) | (962,660)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Unrealized (loss) gain on marketable securities | (10) |  |  |  |  |  |  |  |
Net loss | (261,436) |  |  |  |  |  |  |  |
Balance (in shares) at Sep. 30, 2023 |  |  | 2,369,797 | 18,494,192 |  |  |  |  |
Balance at Sep. 30, 2023 | 22,249 |  | $ 0 | $ 2 |  | 1,246,385 |  | (42) | (1,224,096)
Balance (in shares) at Mar. 31, 2023 |  |  | 2,369,797 | 18,283,074 |  |  |  |  |
Balance at Mar. 31, 2023 | 150,136 |  | $ 0 | $ 2 |  | 1,189,776 |  | (86) | (1,039,556)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs (in shares) |  |  |  | 85,901 | 90,058 |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs | 21,754 | 6,251 |  |  |  | 21,754 | 6,251 |  |
Stock-based compensation expense related to equity-classified awards and Compensation expense related to stock options for services | 10,973 |  |  |  |  | 10,973 |  |  |
Unrealized (loss) gain on marketable securities | (3) |  |  |  |  |  |  | (3) |
Hercules warrant | 195 |  |  |  |  | 195 |  |  |
Net loss | (85,800) |  |  |  |  |  |  |  | (85,800)
Balance (in shares) at Jun. 30, 2023 |  |  | 2,369,797 | 18,459,033 |  |  |  |  |
Balance at Jun. 30, 2023 | 103,506 |  | $ 0 | $ 2 |  | 1,228,949 |  | (89) | (1,125,356)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs (in shares) |  |  |  | 12,200 | 22,959 |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs | 2,731 | 1,924 |  |  |  | 2,731 | 1,924 |  |
Stock-based compensation expense related to equity-classified awards and Compensation expense related to stock options for services | 12,660 |  |  |  |  | 12,660 |  |  |
Unrealized (loss) gain on marketable securities | 47 |  |  |  |  |  |  | 47 |
Hercules warrant | 121 |  |  |  |  | 121 |  |  |
Net loss | (98,740) |  |  |  |  |  |  |  | (98,740)
Balance (in shares) at Sep. 30, 2023 |  |  | 2,369,797 | 18,494,192 |  |  |  |  |
Balance at Sep. 30, 2023 | $ 22,249 |  | $ 0 | $ 2 |  | 1,246,385 |  | (42) | (1,224,096)
Balance (in shares) at Dec. 31, 2023 | 19,875,427 |  | 2,369,797 | 19,875,427 |  |  |  |  |
Balance at Dec. 31, 2023 | $ 405,333 |  | $ 0 | $ 2 |  | 1,741,153 |  | 468 | (1,336,290)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs (in shares) |  |  |  | 750,000 | 59,236 |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs | 311,560 | 262,145 |  |  |  | 311,560 | 262,145 |  |
Stock-based compensation expense related to equity-classified awards and Compensation expense related to stock options for services | 19,902 |  |  |  |  | 19,902 |  |  |
Unrealized (loss) gain on marketable securities | (640) |  |  |  |  |  |  | (640) |
Net loss | (147,541) |  |  |  |  |  |  |  | (147,541)
Balance (in shares) at Mar. 31, 2024 |  |  | 2,369,797 | 20,684,663 |  |  |  |  |
Balance at Mar. 31, 2024 | $ 850,759 |  | $ 0 | $ 2 |  | 2,334,760 |  | (172) | (1,483,831)
Balance (in shares) at Dec. 31, 2023 | 19,875,427 |  | 2,369,797 | 19,875,427 |  |  |  |  |
Balance at Dec. 31, 2023 | $ 405,333 |  | $ 0 | $ 2 |  | 1,741,153 |  | 468 | (1,336,290)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Unrealized (loss) gain on marketable securities | 803 |  |  |  |  |  |  |  |
Net loss | $ (406,476) |  |  |  |  |  |  |  |
Balance (in shares) at Sep. 30, 2024 | 21,806,436 |  | 2,369,797 | 21,806,436 |  |  |  |  |
Balance at Sep. 30, 2024 | $ 777,155 |  | $ 0 | $ 2 |  | 2,518,648 |  | 1,271 | (1,742,766)
Balance (in shares) at Mar. 31, 2024 |  |  | 2,369,797 | 20,684,663 |  |  |  |  |
Balance at Mar. 31, 2024 | 850,759 |  | $ 0 | $ 2 |  | 2,334,760 |  | (172) | (1,483,831)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs (in shares) |  |  |  | 346,153 | 670,077 |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs | 85,950 | 48,174 |  |  |  | 85,950 | 48,174 |  |
Stock-based compensation expense related to equity-classified awards and Compensation expense related to stock options for services | 24,404 |  |  |  |  | 24,404 |  |  |
Unrealized (loss) gain on marketable securities | (196) |  |  |  |  |  |  | (196) |
Net loss | (151,971) |  |  |  |  |  |  |  | (151,971)
Balance (in shares) at Jun. 30, 2024 |  |  | 2,369,797 | 21,700,893 |  |  |  |  |
Balance at Jun. 30, 2024 | 857,120 |  | $ 0 | $ 2 |  | 2,493,288 |  | (368) | (1,635,802)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs (in shares) |  |  |  |  | 105,543 |  |  |  |
Issuance of common shares and sale of warrants in equity offerings, excluding to related parties, net of transaction costs |  | $ 7,462 |  |  |  |  | $ 7,462 |  |
Stock-based compensation expense related to equity-classified awards and Compensation expense related to stock options for services | 17,898 |  |  |  |  | 17,898 |  |  |
Unrealized (loss) gain on marketable securities | 1,639 |  |  |  |  |  |  | 1,639 |
Net loss | $ (106,964) |  |  |  |  |  |  |  | (106,964)
Balance (in shares) at Sep. 30, 2024 | 21,806,436 |  | 2,369,797 | 21,806,436 |  |  |  |  |
Balance at Sep. 30, 2024 | $ 777,155 |  | $ 0 | $ 2 |  | $ 2,518,648 |  | $ 1,271 | $ (1,742,766)

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