<SEC-DOCUMENT>0001104659-25-088744.txt : 20250909
<SEC-HEADER>0001104659-25-088744.hdr.sgml : 20250909
<ACCEPTANCE-DATETIME>20250909212419
ACCESSION NUMBER:		0001104659-25-088744
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250909
DATE AS OF CHANGE:		20250909

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MADRIGAL PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001157601
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-33277
		FILM NUMBER:		251304503

	BUSINESS ADDRESS:	
		STREET 1:		200 BARR HARBOR DRIVE, SUITE 400
		CITY:			WEST CONSHOHOCKEN
		STATE:			PA
		ZIP:			19428
		BUSINESS PHONE:		404-380-9263

	MAIL ADDRESS:	
		STREET 1:		200 BARR HARBOR DRIVE, SUITE 400
		CITY:			WEST CONSHOHOCKEN
		STATE:			PA
		ZIP:			19428

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SYNTA PHARMACEUTICALS CORP
		DATE OF NAME CHANGE:	20010815

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sibold William John
		CENTRAL INDEX KEY:			0001518611
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O MADRIGAL PHARMACEUTICALS, INC., FOUR
		STREET 2:		TOWER BRIDGE, 200 BARR HARBOR DR STE 200
		CITY:			WEST CONSHOHOCKEN
		STATE:			PA
		ZIP:			19428
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Sibold William John -->
          <cik>0001518611</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001157601</issuerCik>
      <issuerName>Madrigal Pharmaceuticals, Inc.</issuerName>
      <secFileNumber>001-33277</secFileNumber>
      <issuerAddress>
        <com:street1>Four Towers Bridge</com:street1>
        <com:street2>200 Barr Harbor Drive, Suite 200</com:street2>
        <com:city>West Conshohocken</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>19428</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>267-824-2827</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>William John Sibold</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer and Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza, 8th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>7279</noOfUnitsSold>
      <aggregateMarketValue>3303210.20</aggregateMarketValue>
      <noOfUnitsOutstanding>22289014</noOfUnitsOutstanding>
      <approxSaleDate>09/09/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq Stock Market</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>09/08/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Unit Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>7279</amountOfSecuritiesAcquired>
      <paymentDate>09/08/2025</paymentDate>
      <natureOfPayment>Vesting of Restricted Stock Units</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>William John Sibold</name>
        <address>
          <com:street1>c/o Madrigal Pharmaceuticals, Inc.</com:street1>
          <com:street2>200 Barr Harbor Drive, Suite 200</com:street2>
          <com:city>West Conshohocken</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19428</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>08/21/2025</saleDate>
      <amountOfSecuritiesSold>7616</amountOfSecuritiesSold>
      <grossProceeds>3047756.28</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The sale of shares of common stock reported on this Form 144 represents the sale of shares pursuant to a sell-to-cover transaction in order to satisfy tax withholding obligations in connection with the vesting of Restricted Stock Units previously granted to the Reporting Person.</remarks>
    <noticeSignature>
      <noticeDate>09/09/2025</noticeDate>
      <signature>/s/ William John Sibold</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
