Income Taxes (Tables)
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12 Months Ended |
Dec. 31, 2019 |
| Income Tax Disclosure [Abstract] |
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| Loss Before Provision For (Benefit From) Income Taxes |
Loss before (benefit from) provision for income taxes for the years ended December 31, 2019, 2018 and 2017 consist of the following (in thousands): | | | | | | | | | | | | | | Years Ended December 31, | | 2019 | | 2018 | | 2017 | United States | $ | (508,595 | ) | | $ | (380,473 | ) | | $ | (247,784 | ) | Foreign | (6,121 | ) | | (3,935 | ) | | (8,212 | ) | Loss before (benefit from) provision for income taxes | $ | (514,716 | ) | | $ | (384,408 | ) | | $ | (255,996 | ) |
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| Provision For (Benefit From) Income Taxes |
The (benefit from) provision for income taxes for the years ended December 31, 2019, 2018 and 2017 consist of the following components (in thousands): | | | | | | | | | | | | | | Years Ended December 31, | | 2019 | | 2018 | | 2017 | Current: | | | | | | Federal | $ | — |
| | $ | (26 | ) | | $ | (252 | ) | State | 505 |
| | 352 |
| | 172 |
| Total current | 505 |
| | 326 |
| | (80 | ) | Deferred: |
| | | | | Federal | (1,200 | ) | | — |
| | — |
| Total deferred | (1,200 | ) | | — |
| | — |
| Total (benefit from) provision for income taxes | $ | (695 | ) | | $ | 326 |
| | $ | (80 | ) |
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| Reconciliation of U.S. Statutory Income Tax Rate to Effective Tax Rate |
The reconciliation of the U.S. statutory income tax rate to our effective tax rate for the years ended December 31, 2019, 2018 and 2017 are as follows: | | | | | | | | | | | Years Ended December 31, | | 2019 | | 2018 | | 2017 | Tax effected at statutory rate | 21.0 | % | | 21.0 | % | | 34.0 | % | State taxes, net of federal benefit | 7.9 | % | | 6.3 | % | | 8.5 | % | Non-deductible items | 1.6 | % | | 0.0 | % | | (1.3 | )% | Change in valuation allowance | (33.0 | )% | | (28.5 | )% | | (20.4 | )% | Federal research and development credits | 2.5 | % | | 1.5 | % | | 4.8 | % | Foreign tax rate differential | (0.2 | )% | | (0.2 | )% | | (1.1 | )% | Impact of federal rate change on net deferred taxes | 0.0 | % | | 0.0 | % | | (25.0 | )% | Other | 0.2 | % | | (0.2 | )% | | 0.5 | % | Effective tax rate | 0.0 | % | | (0.1 | )% | | 0.0 | % |
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| Significant Components of Deferred Tax Assets and Tax Liabilities |
The significant components of our deferred tax assets and tax liabilities as of December 31, 2019 and 2018 are as follows (in thousands): | | | | | | | | | | December 31, | | 2019 | | 2018 | Deferred tax assets: | | | | Net operating loss carry-forwards | $ | 268,173 |
| | $ | 114,932 |
| Stock-based compensation | 43,978 |
| | 33,138 |
| Capitalized licenses, R&D and start-up costs | 19,891 |
| | 22,143 |
| Tax credit carry-forwards | 77,222 |
| | 53,617 |
| Accrued expenses | 7,377 |
| | 16,443 |
| Deferred revenue | 53,475 |
| | 71,209 |
| Operating lease liabilities | 26,571 |
| | — |
| Lease financing obligation | 10,570 |
| | 9,149 |
| Other | 11 |
| | 2,870 |
| Total gross deferred tax assets | 507,268 |
| | 323,501 |
| Less: valuation allowance | (470,753 | ) | | (308,273 | ) | Total deferred tax assets, net of valuation allowance | 36,515 |
| | 15,228 |
| Deferred tax liabilities: | | | | Financing right-of-use assets | (2,612 | ) | | — |
| Operating right-of-use assets | (24,944 | ) | | — |
| Fixed assets | (8,959 | ) | | (15,228 | ) | Total deferred tax liabilities | (36,515 | ) | | (15,228 | ) | Net deferred tax assets | $ | — |
| | $ | — |
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| Reconciliation of the Beginning and Ending Amounts of Unrecognized Tax Benefits Roll Forward |
A reconciliation of the beginning and ending amounts of unrecognized tax benefits during the years ended December 31, 2019 and 2018 are as follows (in thousands): | | | | | Balance as of December 31, 2017 | $ | 940 |
| Decrease due to prior positions | (799 | ) | Increase due to current year tax position | — |
| Balance as of December 31, 2018 | 141 |
| Decrease due to prior positions | — |
| Increase due to current year tax positions | — |
| Balance as of December 31, 2019 | $ | 141 |
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