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Collaboration Agreements - VERTEX Revenue Recognized (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Vertex First Extended Research Term |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |
Revenue recognized | $ 13,452 | $ 0 | $ 0
Vertex Agreement/2019 Amendment |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |
Revenue recognized | 2,053 | 6,197 | 10,400
Vertex Agreements |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |
Revenue recognized | $ 15,505 | $ 6,197 | $ 10,400

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- Definition Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 8 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130549-203045 + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Details
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Data Type: | na
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- Details
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Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

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- Details
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Namespace Prefix: |
Data Type: | na
Balance Type: |
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