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Property and Equipment | 12 Months Ended
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Dec. 31, 2020
Property, Plant and Equipment [Abstract] |
Property and Equipment | Property and Equipment Property and equipment, net as of December 31, 2020 and 2019 consists of the following (in thousands):
|  | December 31,
|  | 2020 |  | 2019 |  |
Laboratory equipment |  | $ | 120,714 |  |  | $ | 108,257 |  |  |
Leasehold improvements |  | 179,901 |  |  | 152,426 |  |  |
Furniture, fixtures and other |  | 4,662 |  |  | 3,316 |  |  |
Computer equipment and software |  | 13,398 |  |  | 11,985 |  |  |
Internally developed software |  | 7,020 |  |  | 7,020 |  |  |
Right-of-use asset, financing |  | 56,348 |  |  | 9,853 |  |  |
Construction in progress |  | 34,507 |  |  | 3,222 |  |  |
|  | 416,550 |  |  | 296,079 |  |  |
Less: Accumulated depreciation |  | (119,661) |  |  | (94,584) |  |  |
Property and equipment, net |  | $ | 296,889 |  |  | $ | 201,495 |  |  |
Depreciation and amortization expense for the years ended December 31, 2020, 2019 and 2018 was $31.3 million, $31.0 million, $24.9 million, respectively.

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99893-112916 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI http://asc.fasb.org/topic&trid=2155823 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=120429125&loc=SL120174063-112916 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 1 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120429125&loc=d3e99779-112916 + Details
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