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Financial Instruments and Fair Value Measurements - Amortized Cost and Estimated Fair Value of Marketable Securities, by Contractual Maturity (Details) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Amortized Cost |  |
Due in one year or less | $ 1,980,963 | $ 864,958
Due after one year through five years | 637,382 | 159,148
Amortized Cost | 2,618,345 | 1,024,106
Estimated Fair Value |  |
Due in one year or less | 1,983,758 | 867,124
Due after one year through five years | 638,848 | 159,987
Total | $ 2,622,606 | $ 1,027,111

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