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Income Taxes - Narrative (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]    
Increase in valuation allowance $ 352,700  
Operating Loss Carryforwards [Line Items]    
Increase in valuation allowance 352,700  
Deferred tax assets 874,145 $ 507,268
Federal    
Operating Loss Carryforwards [Line Items]    
Net operating losses 2,260,000  
Net operating losses that begin to expire in 2030 380,100  
Net operating losses that will carry-forward indefinitely 1,880,000  
Federal | Research and development    
Operating Loss Carryforwards [Line Items]    
Tax credit carry-forwards 73,300  
State    
Operating Loss Carryforwards [Line Items]    
Net operating losses 1,700,000  
Net operating losses that begin to expire in 2030 1,700,000  
State | Research and development    
Operating Loss Carryforwards [Line Items]    
Tax credit carry-forwards 26,100  
State | Federal Orphan Drug    
Operating Loss Carryforwards [Line Items]    
Tax credit carry-forwards 2,000  
State | Investment tax credit    
Operating Loss Carryforwards [Line Items]    
Tax credit carry-forwards $ 3,900