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Financial Instruments and Fair Value Measurements
12 Months Ended
Dec. 31, 2020
Investments, Debt and Equity Securities [Abstract]  
Financial Instruments and Fair Value Measurements Financial Instruments and Fair Value Measurements
Cash and Cash Equivalents and Investments

The following tables summarize our cash and available-for-sale securities by significant investment category at December 31, 2020 and 2019 (in thousands):

December 31, 2020
Amortized
Cost
Unrealized
Gains
Unrealized
Losses
Fair Value
Cash and
Cash
Equivalents
Current
Marketable
Securities
Non-
Current
Marketable
Securities
Cash and cash equivalents$2,623,849 $$— $2,623,850 $2,623,850 $— $— 
Available-for-sale:
Certificates of deposit238,774 49 (4)238,819 — 215,389 23,430 
U.S. treasury securities491,549 69 — 491,618 — 491,618 — 
Debt securities of U.S. government agencies and corporate entities1,888,022 4,294 (147)1,892,169 — 1,276,751 615,418 
$5,242,194 $4,413 $(151)$5,246,456 $2,623,850 $1,983,758 $638,848 
December 31, 2019
Amortized
Cost
Unrealized
Gains
Unrealized
Losses
Fair Value
Cash and
Cash
Equivalents
Current
Marketable
Securities
Non-
Current
Marketable
Securities
Cash and cash equivalents$225,874 $— $— $225,874 $225,874 $— $— 
Available-for-sale:
Certificates of deposit82,028 79 (6)82,101 10,002 69,197 2,902 
U.S. treasury securities117,891 260 (2)118,149 — 110,186 7,963 
Debt securities of U.S. government agencies and corporate entities834,187 2,708 (32)836,863 — 687,741 149,122 
$1,259,980 $3,047 $(40)$1,262,987 $235,876 $867,124 $159,987 


The amortized cost and estimated fair value of marketable securities, by contractual maturity at December 31, 2020 and 2019 are as follows (in thousands):

December 31, 2020
Amortized
Cost
Estimated
Fair Value
Due in one year or less
$1,980,963 $1,983,758 
Due after one year through five years
637,382 638,848 
Total
$2,618,345 $2,622,606 
December 31, 2019
Amortized
Cost
Estimated
Fair Value
Due in one year or less
$864,958 $867,124 
Due after one year through five years
159,148 159,987 
Total
$1,024,106 $1,027,111 
In accordance with our investment policy, we place investments in investment grade securities with high credit quality issuers, and generally limit the amount of credit exposure to any one issuer. We evaluate securities for impairment at the end of each reporting period. We did not record any impairment charges related to our available-for-sale securities during the years ended December 31, 2020, 2019 and 2018. We did not recognize any credit losses related allowance to available-for-sale securities as of the years ended December 31, 2020 and 2019.

The following table summarizes the amount of gross unrealized losses and the estimated fair value for our available-for-sale securities in an unrealized loss position by length of time the securities have been in an unrealized loss position at December 31, 2020 and 2019 (in thousands):

Less than 12 Months12 Months or MoreTotal
Gross Unrealized LossesEstimated Fair ValueGross Unrealized LossesEstimated Fair ValueGross Unrealized LossesEstimated Fair Value
As of December 31, 2020:
Certificates of deposit$(4)$81,524 $— $— $(4)$81,524 
Debt securities of U.S. government agencies and corporate entities(148)507,016 — — (148)507,016 
Total$(152)$588,540 $— $— $(152)$588,540 
As of December 31, 2019:
Certificates of deposit$(6)$12,822 $— $— $(6)$12,822 
U.S. treasury securities(2)9,979 — — (2)9,979 
Debt securities of U.S. government agencies and corporate entities(32)62,360 — — (32)62,360 
Total$(40)$85,161 $— $— $(40)$85,161 

At December 31, 2020 and 2019, we held 108 and 19 individual available-for-sale securities, respectively, out of our total investment portfolio that were in a continuous unrealized loss position for less than 12 months. We neither intend to sell these investments nor conclude that we are more-likely-than-not that we will have to sell them before recovery of their carrying values. We also believe that we will be able to collect both principal and interest amounts due to us at maturity.

Assets and Liabilities Measured at Fair Value on a Recurring Basis
The following tables summarize our financial assets measured at fair value on a recurring basis as of December 31, 2020 and 2019 (in thousands):
Fair Value at December 31, 2020Fair Value Measurement Using
Level 1Level 2
Assets:
Money market funds$620,947 $620,947 $— 
Certificates of deposit238,819 — 238,819 
U.S. treasury securities491,618 — 491,618 
Debt securities of U.S. government agencies and corporate entities1,892,169 — 1,892,169 
Derivative instruments (Note 7)293 — 293 
Total$3,243,846 $620,947 $2,622,899 
Fair Value at December 31, 2019Fair Value Measurement Using
Level 1Level 2
Assets:
Certificates of deposit$82,101 $— $82,101 
U.S. treasury securities118,149 — 118,149 
Debt securities of U.S. government agencies and corporate entities836,863 — 836,863 
Total$1,037,113 $— $1,037,113 

During the years ended December 31, 2020 and 2019, we did not have any financial liabilities measured at fair value on a recurring basis and did not have non-financial assets or liabilities measured at fair value on a recurring basis.