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Property and Equipment
 12 Months Ended
Dec. 31, 2020
Property, Plant and Equipment [Abstract]  
Property and Equipment Property and Equipment
Property and equipment, net as of December 31, 2020 and 2019 consists of the following (in thousands):
December 31,
20202019
Laboratory equipment
$120,714 $108,257 
Leasehold improvements179,901 152,426 
Furniture, fixtures and other4,662 3,316 
Computer equipment and software
13,398 11,985 
Internally developed software
7,020 7,020 
Right-of-use asset, financing
56,348 9,853 
Construction in progress
34,507 3,222 
416,550 296,079 
Less: Accumulated depreciation
(119,661)(94,584)
Property and equipment, net
$296,889 $201,495 

Depreciation and amortization expense for the years ended December 31, 2020, 2019 and 2018 was $31.3 million, $31.0 million, $24.9 million, respectively.