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Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2020

Accounting Policies [Abstract]

Reconciliation of Cash and Cash Equivalents

The following table provides a reconciliation of cash, cash equivalents and restricted cash in the consolidated balance sheets that sum to the total of the same such amounts shown in the consolidated statements of cash flows (in thousands):

						December 31,
						2020						2019
Cash and cash equivalents						$	2,623,850					$	235,876
Restricted cash						1,032						1,032
Restricted cash, non-current						11,053						10,791
Total cash, cash equivalents and restricted cash shown in the consolidated statements of cash flows						$	2,635,935					$	247,699

Reconciliation of Restricted Cash

The following table provides a reconciliation of cash, cash equivalents and restricted cash in the consolidated balance sheets that sum to the total of the same such amounts shown in the consolidated statements of cash flows (in thousands):

						December 31,
						2020						2019
Cash and cash equivalents						$	2,623,850					$	235,876
Restricted cash						1,032						1,032
Restricted cash, non-current						11,053						10,791
Total cash, cash equivalents and restricted cash shown in the consolidated statements of cash flows						$	2,635,935					$	247,699

Entities that Accounted for More than 10% of Total Revenue and Accounts Receivable

A significant portion of our revenue to date has been generated from the following entities that accounted for more than 10% of total revenue and accounts receivable for the periods presented:

			Percentage of Revenue Years Ended December 31,																		Percentage of  Accounts Receivable December 31,
			2020						2019						2018						2020						2019
Merck			*						61		%				49		%				*						13		%
BARDA			65		%				13		%				*						22		%				54		%
Vertex			*						10		%				*						*						17		%
AstraZeneca			*						*						34		%				*						*
U.S. Government (excluding BARDA)			24		%				*						*						*						*
European Commission			*						*						*						28		%				*
United Kingdom Government			*						*						*						11		%				*
South Korea Government			*						*						*						24		%				*

________

* - Represents an amount of less than 10%

Estimated Useful Lives of Property and Equipment

The estimated useful lives of property and equipment are described below:

						Estimated Useful Life
Laboratory equipment						5 years
Leasehold improvements						Lesser of estimated useful life of improvement or remaining life of related lease
Computer equipment and software						3 years
Internally developed software						3 years
Furniture, fixtures and other						5 years
Right of use asset, financing						Lease term

Property and equipment, net as of December 31, 2020 and 2019 consists of the following (in thousands):

						December 31,
						2020						2019
Laboratory equipment						$	120,714					$	108,257
Leasehold improvements						179,901						152,426
Furniture, fixtures and other						4,662						3,316
Computer equipment and software						13,398						11,985
Internally developed software						7,020						7,020
Right-of-use asset, financing						56,348						9,853
Construction in progress						34,507						3,222
						416,550						296,079
Less: Accumulated depreciation						(119,661)						(94,584)
Property and equipment, net						$	296,889					$	201,495

Components of Accumulated Other Comprehensive Loss

The components of accumulated other comprehensive gain (loss) for the years ended December 31, 2020 and 2019 are as follows (in thousands): 

			Unrealized Gain on Available-for-Sale Debt Securities
Accumulated other comprehensive loss, balance at December 31, 2018			$	(1,320)
Other comprehensive income			3,124
Accumulated other comprehensive gain, balance at December 31, 2019			1,804
Other comprehensive income			1,200
Accumulated other comprehensive gain, balance at December 31, 2020			$	3,004

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