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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenue:      
Revenues $ 803,395 $ 60,209 $ 135,068
Operating expenses:      
Cost of sales 7,933 0 0
Research and development 1,370,339 496,309 454,082
Selling, general and administrative 188,267 109,620 94,252
Total operating expenses 1,566,539 605,929 548,334
Loss from operations (763,144) (545,720) (413,266)
Interest income 24,715 38,530 27,023
Other (expense) income, net (6,084) (7,526) 1,835
Loss before provision for (benefit from) income taxes (744,513) (514,716) (384,408)
Provision for (benefit from) income taxes 2,551 (695) 326
Net loss (747,064) (514,021) (384,734)
Reconciliation of net loss to net loss attributable to common stockholders:      
Premium paid on repurchase of preferred stock 0 0 (4,127)
Cumulative preferred stock dividends 0 0 (12,996)
Net loss attributable to common stockholders $ (747,064) $ (514,021) $ (401,857)
Net loss per share attributable to common stockholders, basic and diluted (usd per share) $ (1.96) $ (1.55) $ (4.95)
Weighted average common shares used in net loss per share attributable to common stockholders, basic and diluted (in shares) 381,333,059 330,802,136 81,114,183
Grant revenue      
Revenue:      
Revenues $ 528,905 $ 12,173 $ 12,556
Product sales      
Revenue:      
Revenues 199,872 0 0
Collaboration revenue      
Revenue:      
Revenues $ 74,618 $ 48,036 $ 122,512