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Collaboration Agreements - Composition of the Total Transaction Price (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Remaining performance obligations	$ 87,225
Combined 2018 AZ Agreements
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Remaining performance obligations	396,830	$ 401,782
Combined 2018 AZ Agreements | Upfront payment
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Remaining performance obligations	240,000	240,000
Combined 2018 AZ Agreements | Sublicense reimbursement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Remaining performance obligations	1,000	1,000
Combined 2018 AZ Agreements | Milestone payment | Toxicity milestone payment
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Remaining performance obligations	60,000	60,000
Combined 2018 AZ Agreements | Milestone payment | Competition milestone payment
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Remaining performance obligations	60,000	60,000
Combined 2018 AZ Agreements | Estimated Reimbursement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Remaining performance obligations	$ 35,830	$ 40,782

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Amount of transaction price allocated to performance obligation that has not been recognized as revenue.

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 13
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130556-203045

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