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Collaboration Agreements - VERTEX Revenue Recognized (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Vertex First Extended Research Term
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue recognized	$ 13,452	$ 0	$ 0
Vertex Agreement/2019 Amendment
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue recognized	2,053	6,197	10,400
Vertex Agreements
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue recognized	$ 15,505	$ 6,197	$ 10,400

X

- Definition

Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 8
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130549-203045

+ Details

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X

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

+ Details

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- Details

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- Details

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- Details

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