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Property, Plant and Equipment, Net
 6 Months Ended
Jun. 30, 2024
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment, Net
8. Property, Plant and Equipment, Net

Property, plant and equipment, net, as of June 30, 2024 and December 31, 2023 consisted of the following (in millions):
June 30,December 31,
20242023
Land and land improvements
$22 $22 
Manufacturing and laboratory equipment355 345 
Leasehold improvements
664 522 
Furniture, fixtures and other33 26 
Computer equipment and software
136 74 
Construction in progress
961 860 
Right-of-use assets, financing (Note 10)
529 529 
Total2,700 2,378 
Less: Accumulated depreciation
(504)(433)
Property, plant and equipment, net$2,196 $1,945 

Depreciation and amortization expense for three and six months ended June 30, 2024 was $40 million and $75 million, respectively. Depreciation and amortization expense for the three and six months ended June 30, 2023 was $90 million and $168 million, respectively.