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v3.25.4

Income Taxes - Significant Components of Deferred Tax Assets and Tax Liabilities (Details) - USD ($) $ in Millions | Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
--- | --- | --- | --- | ---
Deferred tax assets: |  |  |  |
Net operating loss carryforwards | $ 1,156 | $ 424 |  |
Stock-based compensation | 129 | 131 |  |
Capitalized licenses, research and development and start-up costs | 1,693 | 1,794 |  |
Tax credit carryforwards | 308 | 251 |  |
Operating lease liabilities | 134 | 138 |  |
Other comprehensive income | 3 | 4 |  |
Inventory reserve and capitalization | 152 | 205 |  |
Wholesaler chargebacks, discounts and fees | 26 | 43 |  |
Returns and other fees | 116 | 86 |  |
Outside basis difference | 84 | 125 |  |
Other | 213 | 160 |  |
Total deferred tax assets | 4,014 | 3,361 |  |
Less: valuation allowance | (3,738) | (3,084) | $ (2,224) | $ (155)
Net deferred tax assets | 276 | 277 |  |
Deferred tax liabilities: |  |  |  |
Right-of-use assets, operating | (135) | (139) |  |
Property, plant and equipment | (58) | (55) |  |
Other | (23) | (16) |  |
Total deferred tax liabilities | (216) | (210) |  |
Net deferred tax assets | $ 60 | $ 67 |  |

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