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Property, Plant and Equipment, Net
 12 Months Ended
Dec. 31, 2025
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment, Net
8. Property, Plant and Equipment, Net

Property, plant and equipment, net as of December 31, 2025 and 2024 consisted of the following (in millions):
December 31,
20252024
Land and land improvements$78 $59 
Building and building improvements1,183 743 
Manufacturing and laboratory equipment542 344 
Leasehold improvements403 207 
Furniture, fixtures and other
39 31 
Computer equipment and software
196 150 
Construction in progress
298 1,057 
Right-of-use assets, financing (Note 10)
132 132 
Total
2,871 2,723 
Less: Accumulated depreciation
(737)(527)
Property, plant and equipment, net$2,134 $2,196 

Depreciation and amortization expense for the years ended December 31, 2025, 2024, and 2023 was $211 million, $185 million, and $617 million, respectively.