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Property, Plant and Equipment, Net
 3 Months Ended
Mar. 31, 2026
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment, Net
8. Property, Plant and Equipment, Net

Property, plant and equipment, net, as of March 31, 2026 and December 31, 2025 consisted of the following (in millions):
March 31,December 31,
20262025
Land and land improvements
$77 $78 
Building and building improvements
1,216 1,183 
Manufacturing and laboratory equipment543 542 
Leasehold improvements
408 403 
Furniture, fixtures and other40 39 
Computer equipment and software
196 196 
Construction in progress
268 298 
Right-of-use assets, financing (Note 10)
132 132 
Total2,880 2,871 
Less: Accumulated depreciation
(794)(737)
Property, plant and equipment, net$2,086 $2,134 

Depreciation and amortization expense related to property, plant and equipment for the three months ended March 31, 2026 and 2025 was $56 million and $38 million, respectively.