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<element name="AdjustmentToAdditionalPaidInCapitalEarnoutLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AdjustmentToAdditionalPaidInCapitalEarnoutLiabilities" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="AdjustmentToAdditionalPaidInCapitalBusinessCombinationProceedsNetOfTransactionCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AdjustmentToAdditionalPaidInCapitalBusinessCombinationProceedsNetOfTransactionCosts" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AdjustmentToAdditionalPaidInCapitalBusinessCombinationTransactionCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AdjustmentToAdditionalPaidInCapitalBusinessCombinationTransactionCosts" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="PaymentOfTransactionCostsThroughCash" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PaymentOfTransactionCostsThroughCash" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AdjustmentToAdditionalPaidInCapitalAdjustmentForWarrantLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AdjustmentToAdditionalPaidInCapitalAdjustmentForWarrantLiabilities" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="RedemptionOfCommonStockSharesOfThePredecessorCompany" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_RedemptionOfCommonStockSharesOfThePredecessorCompany" substitutionGroup="xbrli:item" />
<element name="CommonStockSharesNewlyIssuedInThePredecessorCompany" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesNewlyIssuedInThePredecessorCompany" substitutionGroup="xbrli:item" />
<element name="CommonStockSharesIssuedDueToExerciseOfStockOptionsImmediatelyBeforeClosing" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedDueToExerciseOfStockOptionsImmediatelyBeforeClosing" substitutionGroup="xbrli:item" />
<element name="CommonStockSharesIssuedDueToExerciseOfWarrantsImmediatelyBeforeClosing" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedDueToExerciseOfWarrantsImmediatelyBeforeClosing" substitutionGroup="xbrli:item" />
<element name="CommonStockSharesIssuedInTheNewCompanyUponConversionOfTemporaryEquity" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedInTheNewCompanyUponConversionOfTemporaryEquity" substitutionGroup="xbrli:item" />
<element name="CommonStockSharesIssuedPursuantToPrivateInvestmentInPublicEquity" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedPursuantToPrivateInvestmentInPublicEquity" substitutionGroup="xbrli:item" />
<element name="StockSharesIssuedAggregateBusinessCombinationPrivateInvestmentInPublicEquity" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_StockSharesIssuedAggregateBusinessCombinationPrivateInvestmentInPublicEquity" substitutionGroup="xbrli:item" />
<element name="CommonStockSharesIssuedInTheNewCompany" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedInTheNewCompany" substitutionGroup="xbrli:item" />
<element name="StatusOfSharesOutstandingBeforeBusinessCombinationMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_StatusOfSharesOutstandingBeforeBusinessCombinationMember" substitutionGroup="xbrli:item" />
<element name="RevenuePerformanceObligationTransactionPriceAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RevenuePerformanceObligationTransactionPriceAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="RevenuePerformanceObligationTransactionPriceDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RevenuePerformanceObligationTransactionPriceDomain" substitutionGroup="xbrli:item" />
<element name="TwoThousandAndTwentyThreeMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TwoThousandAndTwentyThreeMember" substitutionGroup="xbrli:item" />
<element name="RemainderOfTwoThousandAndTwentyTwoMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RemainderOfTwoThousandAndTwentyTwoMember" substitutionGroup="xbrli:item" />
<element name="CollaborativeResearchAndOtherProfessionalServicesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CollaborativeResearchAndOtherProfessionalServicesMember" substitutionGroup="xbrli:item" />
<element name="AccessToQuantumComputingSystemsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AccessToQuantumComputingSystemsMember" substitutionGroup="xbrli:item" />
<element name="DeferralOfRevenue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_DeferralOfRevenue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="RecognitionOfDeferredRevenues" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_RecognitionOfDeferredRevenues" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="RigettiHoldingsIncMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RigettiHoldingsIncMember" substitutionGroup="xbrli:item" />
<element name="CurrentPortionOfLongTermDebtGross" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_CurrentPortionOfLongTermDebtGross" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AccruedFinalPaymentFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_AccruedFinalPaymentFee" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CurrentPortionOfOutstandingPrincipalAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_CurrentPortionOfOutstandingPrincipalAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="TrancheBMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheBMember" substitutionGroup="xbrli:item" />
<element name="TrancheAMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheAMember" substitutionGroup="xbrli:item" />
<element name="TrancheCMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheCMember" substitutionGroup="xbrli:item" />
<element name="InvestorNameAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_InvestorNameAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="InvestorNameDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_InvestorNameDomain" substitutionGroup="xbrli:item" />
<element name="LoanAndSecurityAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_LoanAndSecurityAgreementMember" substitutionGroup="xbrli:item" />
<element name="VentureCapitalMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_VentureCapitalMember" substitutionGroup="xbrli:item" />
<element name="DebtInstrumentPaymentFeepercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_DebtInstrumentPaymentFeepercentage" substitutionGroup="xbrli:item" />
<element name="WithdrawnCreditFacility" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_WithdrawnCreditFacility" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="PercentageOfDebtRelatedCostPaidUponTheConsummationOfMerger" type="xbrli:pureItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PercentageOfDebtRelatedCostPaidUponTheConsummationOfMerger" substitutionGroup="xbrli:item" />
<element name="CommonStockWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockWarrantsMember" substitutionGroup="xbrli:item" />
<element name="SeriesCOnePreferredStockMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_SeriesCOnePreferredStockMember" substitutionGroup="xbrli:item" />
<element name="EquityAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_EquityAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="EquityDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_EquityDomain" substitutionGroup="xbrli:item" />
<element name="Classofwarrantsorrightsaggregatefairvalueofwarrantsatthetimeofgrant" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_Classofwarrantsorrightsaggregatefairvalueofwarrantsatthetimeofgrant" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="Classofwarrantsvestingpercentage" type="xbrli:pureItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_Classofwarrantsvestingpercentage" substitutionGroup="xbrli:item" />
<element name="Classofwarrantsorrightswarrantsissuedduringtheperiodunits" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_Classofwarrantsorrightswarrantsissuedduringtheperiodunits" substitutionGroup="xbrli:item" />
<element name="ClassOfWarrantOrRightIssuedDuringPeriodWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_ClassOfWarrantOrRightIssuedDuringPeriodWarrants" substitutionGroup="xbrli:item" />
<element name="Deferredassetsinconnectionwithwarrantsissuedtocustomer" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_Deferredassetsinconnectionwithwarrantsissuedtocustomer" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="Deferredassetredeuctionofrevenue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_Deferredassetredeuctionofrevenue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ClassOfWarrantOrRightGrandDateFairValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ClassOfWarrantOrRightGrandDateFairValue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="WaitingPeriodAfterWhichTheShareTradingDaysAreConsidered" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_WaitingPeriodAfterWhichTheShareTradingDaysAreConsidered" substitutionGroup="xbrli:item" />
<element name="ClassOfInvestorsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ClassOfInvestorsAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="ClassOfInvestorsDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ClassOfInvestorsDomain" substitutionGroup="xbrli:item" />
<element name="CustomerWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CustomerWarrantsMember" substitutionGroup="xbrli:item" />
<element name="TrinityWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrinityWarrantsMember" substitutionGroup="xbrli:item" />
<element name="AtinitialrecognitionMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AtinitialrecognitionMember" substitutionGroup="xbrli:item" />
<element name="DisclosureofvestingstatusofwarrantsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureofvestingstatusofwarrantsAbstract" substitutionGroup="xbrli:item" />
<element name="DisclosureOfVestingStatusOfWarrantsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureOfVestingStatusOfWarrantsTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="StatusOfVestingAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_StatusOfVestingAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="StatusOfVestingDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_StatusOfVestingDomain" substitutionGroup="xbrli:item" />
<element name="UnvestedCustomerWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_UnvestedCustomerWarrantsMember" substitutionGroup="xbrli:item" />
<element name="VestedCustomerWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_VestedCustomerWarrantsMember" substitutionGroup="xbrli:item" />
<element name="DisclosureofvestingstatusofwarrantsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureofvestingstatusofwarrantsLineItems" substitutionGroup="xbrli:item" />
<element name="StockIssuedDuringPeriodWarrantsIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_StockIssuedDuringPeriodWarrantsIssued" substitutionGroup="xbrli:item" />
<element name="RigettiMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RigettiMember" substitutionGroup="xbrli:item" />
<element name="AgreementNameAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AgreementNameAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="AgreementNameDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AgreementNameDomain" substitutionGroup="xbrli:item" />
<element name="ForwardWarrantAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ForwardWarrantAgreementMember" substitutionGroup="xbrli:item" />
<element name="AmpereComputingLlcMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AmpereComputingLlcMember" substitutionGroup="xbrli:item" />
<element name="MeasurementInputProbabilityOfOccurringTheContingencyMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_MeasurementInputProbabilityOfOccurringTheContingencyMember" substitutionGroup="xbrli:item" />
<element name="ContingentEarnOutLiabilityFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ContingentEarnOutLiabilityFairValueDisclosure" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ForwardWarrantAgreementFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ForwardWarrantAgreementFairValueDisclosure" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ForwardWarrantAgreementLiabilityFairValueDisclosureMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ForwardWarrantAgreementLiabilityFairValueDisclosureMember" substitutionGroup="xbrli:item" />
<element name="ContingentEarnOutLiabilityMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ContingentEarnOutLiabilityMember" substitutionGroup="xbrli:item" />
<element name="DerivativeWarrantLiabilitiesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DerivativeWarrantLiabilitiesMember" substitutionGroup="xbrli:item" />
<element name="ScheduleOfShareBasedCompensationRestrictedStockAndRestrictedStockUnitsActivityAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ScheduleOfShareBasedCompensationRestrictedStockAndRestrictedStockUnitsActivityAbstract" substitutionGroup="xbrli:item" />
<element name="RestrictedStockUnitsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RestrictedStockUnitsTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="ScheduleOfShareBasedCompensationRestrictedStockAndRestrictedStockUnitsActivityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ScheduleOfShareBasedCompensationRestrictedStockAndRestrictedStockUnitsActivityLineItems" substitutionGroup="xbrli:item" />
<element name="PercentageOfTheCommonStockOfAllClassesOutstandingOnPrecedingYear" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PercentageOfTheCommonStockOfAllClassesOutstandingOnPrecedingYear" substitutionGroup="xbrli:item" />
<element name="TwoThousandTwentyTwoEquityIncentivePlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TwoThousandTwentyTwoEquityIncentivePlanMember" substitutionGroup="xbrli:item" />
<element name="NetIncomeLossRelationToCommonStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_NetIncomeLossRelationToCommonStock" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ConvertibleSeriesCPreferredStockMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ConvertibleSeriesCPreferredStockMember" substitutionGroup="xbrli:item" />
<element name="ConvertibleSeriesC1PreferredStockMemberMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ConvertibleSeriesC1PreferredStockMemberMember" substitutionGroup="xbrli:item" />
<element name="PercentageOfTheAggregateNumberOfSharesOfCommonStockIssuedAndOutstandingImmediatelyPriorToTheExecutionOfTheAgreement" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PercentageOfTheAggregateNumberOfSharesOfCommonStockIssuedAndOutstandingImmediatelyPriorToTheExecutionOfTheAgreement" substitutionGroup="xbrli:item" />
<element name="WeightedAverageSharePriceAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_WeightedAverageSharePriceAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="WeightedAverageSharePriceDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_WeightedAverageSharePriceDomain" substitutionGroup="xbrli:item" />
<element name="CommonStockPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockPurchaseAgreementMember" substitutionGroup="xbrli:item" />
</schema>
