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Balance Sheet Components - Property and Equipment (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 693,056	$ 484,601
Less: Accumulated depreciation and amortization	(171,727)	(135,808)
Property, plant and equipment, net	521,329	348,793
Depreciation and amortization	$ 54,700	37,700	$ 24,000
Clinical and manufacturing equipment
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Useful Life	10 years
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 236,179	183,392
Computer hardware
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Useful Life	3 years
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 34,297	24,933
Computer software
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Useful Life	3 years
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 59,617	54,756
Furniture and fixtures
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Useful Life	5 years
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 33,436	16,271
Leasehold improvements
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 77,168	37,756
Building
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Useful Life	20 years
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 139,315	63,887
Land
Property, Plant and Equipment, Net [Abstract]
Property and equipment	17,630	17,630
Construction in progress
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 95,414	$ 85,976

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- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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