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Balance Sheet Components - Property and Equipment (Detail) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Property, Plant and Equipment, Net [Abstract] |  |  |
Property and equipment | $ 1,681,581 | $ 1,441,027 |
Less: Accumulated depreciation and impairment charges | (449,726) | (359,101) |
Total property, plant and equipment, net | 1,231,855 | 1,081,926 |
Depreciation | 109,800 | 92,100 | $ 80,100
Clinical and manufacturing equipment |  |  |
Property, Plant and Equipment, Net [Abstract] |  |  |
Property and equipment | $ 583,776 | 452,876 |
Building |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated useful life | 20 years |  |
Property, Plant and Equipment, Net [Abstract] |  |  |
Property and equipment | $ 466,003 | 310,344 |
Leasehold improvements |  |  |
Property, Plant and Equipment, Net [Abstract] |  |  |
Property and equipment | $ 64,238 | 61,289 |
Computer software and hardware |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated useful life | 3 years |  |
Property, Plant and Equipment, Net [Abstract] |  |  |
Property and equipment | $ 120,544 | 117,986 |
Land |  |  |
Property, Plant and Equipment, Net [Abstract] |  |  |
Property and equipment | 58,885 | 58,869 |
Furniture, fixtures and other |  |  |
Property, Plant and Equipment, Net [Abstract] |  |  |
Property and equipment | 102,933 | 71,977 |
Construction in progress |  |  |
Property, Plant and Equipment, Net [Abstract] |  |  |
Property and equipment | $ 285,202 | $ 367,686 |
Maximum | Clinical and manufacturing equipment |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated useful life | 10 years |  |
Maximum | Furniture, fixtures and other |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated useful life | 5 years |  |
Minimum | Furniture, fixtures and other |  |  |
Property, Plant and Equipment [Line Items] |  |  |
Estimated useful life | 2 years |  |

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- Definition Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(13)) -URI https://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 + Details
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