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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Cash flows from operating activities:    
Net loss $ (25,550) $ (42,603)
Adjustments to reconcile net income to net cash used in operating activities:    
Foreign exchange (gain)/loss (1,672) 3,256
Other non-cash items 88 44
Accretion of redemption premium on debt 51 63
Share-based compensation 9,364 6,801
Depreciation 314 328
Changes in operating assets and liabilities:    
Prepaid expenses 1,605 (694)
Tax incentive receivable (380) (6,461)
Other current assets (2,016) (143)
Accounts payable (417) (680)
Accrued expenses (6,285) 6,347
Lease liabilities (305) (338)
Income taxes (939) 164
Other current liabilities (951) (113)
Net cash used in operating activities (27,093) (34,029)
Cash flows from investing activities:    
Purchases of furniture and equipment 0 29
Net cash used in investing activities 0 (29)
Cash flows from financing activities:    
Proceeds from issuance of stock 56,909 67
Proceeds from draw under the Oxford Term Loan 9,996 0
Payments of withholding taxes from share-based awards 0 (1,482)
Proceeds from exercise of share options 1,904 0
Net cash provided by/(used in) financing activities 68,809 (1,415)
Effect of exchange rate changes on cash and cash equivalents 1,184 (1,397)
Net change in cash and cash equivalents 42,900 (36,870)
Cash and cash equivalents at beginning of the period 227,827 148,380
Cash and cash equivalents at end of the period 270,727 111,510
Supplemental Cash Flow Information [Abstract]    
Income taxes paid 1,215 1
Interest paid $ 685 $ 115