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Consolidated Statements of Shareholders’ Equity - USD ($) $ in Thousands | Total | Public Stock Offering | At-The-Market Sales Agreement | Ordinary shares | Ordinary shares Public Stock Offering | Ordinary shares At-The-Market Sales Agreement | Additional paid-in capital | Additional paid-in capital Public Stock Offering | Additional paid-in capital At-The-Market Sales Agreement | Treasury Stock, Common | Accumulated other comprehensive loss | Accumulated deficit
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2021 |  |  |  | 489,177,550 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2021 | $ 148,005 |  |  | $ 31,855 |  |  | $ 385,070 |  |  | $ (603) | $ (4,601) | $ (263,716)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (68,701) |  |  |  |  |  |  |  |  |  |  | (68,701)
Issuance of ordinary shares, net of issuance costs (in shares) |  |  |  |  | 114,080,000 | 80,696 |  |  |  |  |  |
Issuance of ordinary shares, net of issuance costs |  | $ 140,197 | $ 67 |  | $ 6,918 | $ 5 |  | $ 133,279 | $ 62 |  |  |
Issuance of ordinary shares to treasury (in shares) |  |  |  | 28,000,000 |  |  |  |  |  |  |  |
Issuance of ordinary shares to treasury | 0 |  |  | $ 1,748 |  |  |  |  |  | (1,748) |  |
Restricted share units vested |  |  |  |  |  |  |  |  |  | 680 |  | (680)
Share options exercised | 1,372 |  |  |  |  |  | 1,250 |  |  | 122 |  |
Share-based compensation | 14,121 |  |  |  |  |  | 14,121 |  |  |  |  |
Common shares withheld for taxes on vested stock awards | (4,723) |  |  |  |  |  | (4,723) |  |  |  |  |
Equity settled share-based compensation reclassified as cash-settled | $ 128 |  |  |  |  |  | 128 |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2022 | 606,301,054 |  |  | 631,338,246 |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2022 | $ 230,466 |  |  | $ 40,526 |  |  | 529,187 |  |  | (1,549) | (4,601) | (333,097)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (54,369) |  |  |  |  |  |  |  |  |  |  | (54,369)
Issuance of ordinary shares, net of issuance costs (in shares) |  |  |  |  |  | 20,321,384 |  |  |  |  |  |
Issuance of ordinary shares, net of issuance costs |  |  | $ 56,909 |  |  | $ 1,227 |  |  | $ 55,682 |  |  |
Issuance of ordinary shares to treasury (in shares) |  |  |  | 16,000,000 |  |  |  |  |  |  |  |
Issuance of ordinary shares to treasury | 0 |  |  | $ 1,018 |  |  |  |  |  | (1,018) |  |
Restricted share units vested |  |  |  |  |  |  |  |  |  | 967 |  | (967)
Share options exercised | 1,949 |  |  |  |  |  | 1,866 |  |  | 83 |  |
Share-based compensation | 19,012 |  |  |  |  |  | 19,012 |  |  |  |  |
Common shares withheld for taxes on vested stock awards | (4,389) |  |  |  |  |  | (4,389) |  |  |  |  |
Equity settled share-based compensation reclassified as cash-settled | $ (295) |  |  |  |  |  | (295) |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2023 | 643,536,094 |  |  | 667,659,630 |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2023 | $ 249,283 |  |  | $ 42,771 |  |  | $ 601,063 |  |  | $ (1,517) | $ (4,601) | $ (388,433)

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