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Organization and description of business operations (Details)
$ / shares in Units, $ in Thousands
 1 Months Ended 12 Months Ended
Aug. 15, 2022
USD ($)
$ / shares
shares
Jun. 30, 2023
USD ($)
Dec. 31, 2023
USD ($)
subsidiary
shares
Dec. 31, 2022
USD ($)
shares
Dec. 31, 2023
£ / shares
Dec. 31, 2023
USD ($)
$ / shares
Rate
Dec. 27, 2023
USD ($)
loanAdvance
Dec. 31, 2022
£ / shares
Dec. 31, 2022
USD ($)
$ / shares
Oct. 14, 2022
USD ($)
loanAdvance
Nov. 30, 2020
USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]                      
Number of wholly owned subsidiaries | subsidiary     1                
Class of Stock [Line Items]                      
Payments for application fees   $ 3,200                  
Accumulated deficit           $ 388,433     $ 333,097    
Number of shares issued in sale (in shares) | shares       80,696              
Number of ordinary shares per ADS 8         800.00%          
Common stock, par value (in pounds sterling per share) | (per share) $ 0.05       £ 0.05     £ 0.05      
Sale of stock price per share (in dollars per share) | $ / shares                 $ 0.86    
Term Loan Facility | Secured Debt                      
Class of Stock [Line Items]                      
Debt instrument, face amount                     $ 30,000
2023 Term Loan | Secured Debt                      
Class of Stock [Line Items]                      
Debt instrument, face amount             $ 400,000        
Line of Credit | Oxford Term Loan                      
Class of Stock [Line Items]                      
Maximum borrowing capacity                   $ 150,000  
Number of loan advances | loanAdvance                   4  
Line of Credit | 2023 Term Loan                      
Class of Stock [Line Items]                      
Maximum borrowing capacity             $ 400,000        
Number of loan advances | loanAdvance             4        
Line of Credit | 2023 Term A Loan                      
Class of Stock [Line Items]                      
Maximum borrowing capacity             $ 50,000        
Line of Credit | 2023 Term B, C, D, E Loan                      
Class of Stock [Line Items]                      
Maximum borrowing capacity             $ 350,000        
Public Stock Offering                      
Class of Stock [Line Items]                      
Consideration received from sale of stock $ 140,200                    
ATM Program                      
Class of Stock [Line Items]                      
Number of shares issued in sale (in shares) | shares     20,321,384                
Sale of stock price per share (in dollars per share) | $ / shares           $ 2.88          
Consideration received from sale of stock     $ 56,900                
American Depository Shares                      
Class of Stock [Line Items]                      
Number of shares issued in sale (in shares) | shares       10,087              
Sale of stock price per share (in dollars per share) | $ / shares                 $ 6.86    
Consideration received from sale of stock       $ 100              
Maximum aggregate offering price           $ 200,000          
Commission fee percentage           3.00%          
Remaining ordinary shares available for sale                 $ 99,200    
American Depository Shares | Public Stock Offering                      
Class of Stock [Line Items]                      
Number of shares issued in sale (in shares) | shares 14,260,000                    
Sale of stock price per share (in dollars per share) | $ / shares $ 10.50                    
American Depository Shares | Over-Allotment Option                      
Class of Stock [Line Items]                      
Number of shares issued in sale (in shares) | shares 1,860,000                    
American Depository Shares | ATM Program                      
Class of Stock [Line Items]                      
Number of shares issued in sale (in shares) | shares     2,540,173                
Sale of stock price per share (in dollars per share) | $ / shares           $ 23.08