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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Operating activities:    
Net loss $ (54,369) $ (68,701)
Adjustments to reconcile net income to net cash used in operating activities:    
Foreign exchange (gain)/loss (1,866) 3,817
Amortization of debt issuance costs 116 80
Accretion of redemption premium on debt 106 108
Share-based compensation 19,012 14,121
Depreciation and amortization 677 636
Changes in operating assets and liabilities:    
Prepaid expenses (1,118) 1,538
Tax incentive receivables (1,104) 3,964
Other current assets 777 (1,325)
Accounts payable 486 (7,146)
Accrued expenses (10,351) (8,504)
Operating lease liabilities (591) (597)
Income taxes (1,037) 136
Other current liabilities (960) 1,196
Net cash used in operating activities (50,222) (59,862)
Cash flows from investing activities:    
Purchases of furniture and equipment 0 (29)
Net cash used in investing activities 0 (29)
Cash flows from financing activities:    
Proceeds from issuance of ordinary shares 56,909 149,797
Payment of offering costs in connection with the issuance of ordinary shares 0 (9,533)
Proceeds from Oxford Term Loan 9,996 10,000
Payment of debt issuance costs (12) (245)
Repayment of SVB Term Loan 0 (5,000)
SVB Term Loan repayment costs 0 (850)
Payments of withholding taxes from share-based awards (4,685) (4,723)
Proceeds from exercise of share options 1,949 1,372
Net cash provided by financing activities 92,869 140,818
Effect of exchange rate changes on cash and cash equivalents 1,298 (1,480)
Net change in cash and cash equivalents 43,945 79,447
Cash and cash equivalents at beginning of the year 227,827 148,380
Cash and cash equivalents at end of the year 271,772 227,827
Supplemental disclosure of cash flow information:    
Income taxes paid 1,245 120
Interest paid 2,006 348
Loss on extinguishment of debt 0 815
Proceeds from (Repayments of) Other Long-Term Debt $ 28,712 $ 0