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Consolidated Statements of Shareholders’ Equity - USD ($) $ in Thousands | Total | At-The-Market Sales Agreement | Ordinary shares | Ordinary shares At-The-Market Sales Agreement | Additional paid-in capital | Additional paid-in capital At-The-Market Sales Agreement | Ordinary shares held in treasury | Accumulated other comprehensive loss | Accumulated deficit
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2022 |  |  | 631,338,246 |  |  |  |  |  |
Beginning balance at Dec. 31, 2022 | $ 230,466 |  | $ 40,526 |  | $ 529,187 |  | $ (1,549) | $ (4,601) | $ (333,097)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |
Net loss | (16,743) |  |  |  |  |  |  |  | (16,743)
Issuance of common shares (in shares) |  |  |  | 20,321,384 |  |  |  |  |
Issuance of common shares |  | $ 56,909 |  | $ 1,227 |  | $ 55,682 |  |  |
Restricted share units vested |  |  |  |  |  |  | 270 |  | (270)
Share options exercised | 1,827 |  |  |  | 1,756 |  | 71 |  |
Share-based compensation | 4,290 |  |  |  | 4,290 |  |  |  |
Ending balance (in shares) at Mar. 31, 2023 |  |  | 651,659,630 |  |  |  |  |  |
Ending balance at Mar. 31, 2023 | 276,749 |  | $ 41,753 |  | 590,915 |  | (1,208) | (4,601) | (350,110)
Beginning balance (in shares) at Dec. 31, 2022 |  |  | 631,338,246 |  |  |  |  |  |
Beginning balance at Dec. 31, 2022 | 230,466 |  | $ 40,526 |  | 529,187 |  | (1,549) | (4,601) | (333,097)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |
Net loss | (40,237) |  |  |  |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2023 |  |  | 651,659,630 |  |  |  |  |  |
Ending balance at Sep. 30, 2023 | 263,533 |  | $ 41,753 |  | 601,180 |  | (746) | (4,601) | (374,053)
Beginning balance (in shares) at Mar. 31, 2023 |  |  | 651,659,630 |  |  |  |  |  |
Beginning balance at Mar. 31, 2023 | 276,749 |  | $ 41,753 |  | 590,915 |  | (1,208) | (4,601) | (350,110)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |
Net loss | (8,807) |  |  |  |  |  |  |  | (8,807)
Restricted share units vested |  |  |  |  |  |  | 226 |  | (226)
Share options exercised | 77 |  |  |  | 70 |  | 7 |  |
Share-based compensation | 5,074 |  |  |  | 5,074 |  |  |  |
Ending balance (in shares) at Jun. 30, 2023 |  |  | 651,659,630 |  |  |  |  |  |
Ending balance at Jun. 30, 2023 | 273,093 |  | $ 41,753 |  | 596,059 |  | (975) | (4,601) | (359,143)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |
Net loss | (14,687) |  |  |  |  |  |  |  | (14,687)
Restricted share units vested |  |  |  |  |  |  | 223 |  | (223)
Share options exercised | 48 |  |  |  | 42 |  | 6 |  |
Share-based compensation | 5,079 |  |  |  | 5,079 |  |  |  |
Ending balance (in shares) at Sep. 30, 2023 |  |  | 651,659,630 |  |  |  |  |  |
Ending balance at Sep. 30, 2023 | $ 263,533 |  | $ 41,753 |  | 601,180 |  | (746) | (4,601) | (374,053)
Beginning balance (in shares) at Dec. 31, 2023 | 643,536,094 |  | 667,659,630 |  |  |  |  |  |
Beginning balance at Dec. 31, 2023 | $ 249,283 |  | $ 42,771 |  | 601,063 |  | (1,517) | (4,601) | (388,433)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |
Net loss | (25,794) |  |  |  |  |  |  |  | (25,794)
Restricted share units vested |  |  |  |  |  |  | 170 |  | (170)
Share options exercised | 816 |  |  |  | 751 |  | 65 |  |
Common shares withheld for taxes on vested stock awards | (3,338) |  |  |  | (3,338) |  |  |  |
Equity settled share-based compensation reclassified as cash-settled | (237) |  |  |  | (237) |  |  |  |
Share-based compensation | 4,258 |  |  |  | 4,258 |  |  |  |
Ending balance (in shares) at Mar. 31, 2024 |  |  | 667,659,630 |  |  |  |  |  |
Ending balance at Mar. 31, 2024 | $ 224,988 |  | $ 42,771 |  | 602,497 |  | (1,282) | (4,601) | (414,397)
Beginning balance (in shares) at Dec. 31, 2023 | 643,536,094 |  | 667,659,630 |  |  |  |  |  |
Beginning balance at Dec. 31, 2023 | $ 249,283 |  | $ 42,771 |  | 601,063 |  | (1,517) | (4,601) | (388,433)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |
Net loss | $ (139,591) |  |  |  |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2024 | 654,649,358 |  | 667,659,630 |  |  |  |  |  |
Ending balance at Sep. 30, 2024 | $ 130,491 |  | $ 42,771 |  | 621,628 |  | (828) | (4,601) | (528,479)
Beginning balance (in shares) at Jun. 30, 2024 |  |  | 667,659,630 |  |  |  |  |  |
Beginning balance at Jun. 30, 2024 | 168,274 |  | $ 42,771 |  | 616,618 |  | (1,203) | (4,601) | (485,311)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |
Net loss | (42,962) |  |  |  |  |  |  |  | (42,962)
Restricted share units vested |  |  |  |  |  |  | 206 |  | (206)
Share options exercised | 3,668 |  |  |  | 3,499 |  | 169 |  |
Common shares withheld for taxes on vested stock awards | (5,600) |  |  |  | (5,600) |  |  |  |
Equity settled share-based compensation reclassified as cash-settled | (543) |  |  |  | (543) |  |  |  |
Share-based compensation | $ 7,654 |  |  |  | 7,654 |  |  |  |
Ending balance (in shares) at Sep. 30, 2024 | 654,649,358 |  | 667,659,630 |  |  |  |  |  |
Ending balance at Sep. 30, 2024 | $ 130,491 |  | $ 42,771 |  | $ 621,628 |  | $ (828) | $ (4,601) | $ (528,479)

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