<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:75cd14a1-3724-4c90-90e9-ddd16db3c975,g:55ee8766-6117-4e3c-b13f-b099bcccf32a-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.comerica.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="cma-20211231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d0df5f50-3533-4217-83af-985f7b1835f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_ec85cece-a8eb-478a-91b1-474bde369e9d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d0df5f50-3533-4217-83af-985f7b1835f8" xlink:to="loc_us-gaap_CommonStockValue_ec85cece-a8eb-478a-91b1-474bde369e9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_cf48e8e9-ab9e-4c4a-b198-f5b0c44e1964" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d0df5f50-3533-4217-83af-985f7b1835f8" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_cf48e8e9-ab9e-4c4a-b198-f5b0c44e1964" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2a516a0e-da67-4f84-9bc3-9521fec85e6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d0df5f50-3533-4217-83af-985f7b1835f8" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2a516a0e-da67-4f84-9bc3-9521fec85e6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_32ddca37-f3f6-449f-af1c-8d94d28c6827" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d0df5f50-3533-4217-83af-985f7b1835f8" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_32ddca37-f3f6-449f-af1c-8d94d28c6827" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_5a72b31a-4533-4b1e-87ec-2931f995ccf8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d0df5f50-3533-4217-83af-985f7b1835f8" xlink:to="loc_us-gaap_TreasuryStockValue_5a72b31a-4533-4b1e-87ec-2931f995ccf8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositLiabilities_90f16be5-bd82-4d33-b84a-11f260aa1f87" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestBearingDepositLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsMoneyMarketDepositsAndNegotiableOrderOfWithdrawalNOW_605ca1a5-8e8e-4189-8e2d-89a17c785d8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositsMoneyMarketDepositsAndNegotiableOrderOfWithdrawalNOW"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestBearingDepositLiabilities_90f16be5-bd82-4d33-b84a-11f260aa1f87" xlink:to="loc_us-gaap_DepositsMoneyMarketDepositsAndNegotiableOrderOfWithdrawalNOW_605ca1a5-8e8e-4189-8e2d-89a17c785d8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsSavingsDeposits_dc0fa127-36fe-4638-b2ee-b54093c39218" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepositsSavingsDeposits"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestBearingDepositLiabilities_90f16be5-bd82-4d33-b84a-11f260aa1f87" xlink:to="loc_us-gaap_DepositsSavingsDeposits_dc0fa127-36fe-4638-b2ee-b54093c39218" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_DepositsCustomerCertificatesDeposits_d6638b8a-c696-48a9-8d17-2a85f2924410" xlink:href="cma-20211231.xsd#cma_DepositsCustomerCertificatesDeposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestBearingDepositLiabilities_90f16be5-bd82-4d33-b84a-11f260aa1f87" xlink:to="loc_cma_DepositsCustomerCertificatesDeposits_d6638b8a-c696-48a9-8d17-2a85f2924410" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingForeignDepositTimeDeposits_9e831011-38c3-4045-befe-8a3a944ed8ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestBearingForeignDepositTimeDeposits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestBearingDepositLiabilities_90f16be5-bd82-4d33-b84a-11f260aa1f87" xlink:to="loc_us-gaap_InterestBearingForeignDepositTimeDeposits_9e831011-38c3-4045-befe-8a3a944ed8ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_de1c2aac-2de3-4256-acb5-3ddca6c1e0dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_1916939b-1fe7-4227-82ea-82697191e79b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_de1c2aac-2de3-4256-acb5-3ddca6c1e0dc" xlink:to="loc_us-gaap_Liabilities_1916939b-1fe7-4227-82ea-82697191e79b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_6e1d7ddc-c3e9-4148-b3ad-d28e9d660cf0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_de1c2aac-2de3-4256-acb5-3ddca6c1e0dc" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_6e1d7ddc-c3e9-4148-b3ad-d28e9d660cf0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_4d1f9ef9-89a1-438c-a072-72a3ac5a464f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_465734bb-8508-47e1-855a-f2bfb0797f92" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Deposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d1f9ef9-89a1-438c-a072-72a3ac5a464f" xlink:to="loc_us-gaap_Deposits_465734bb-8508-47e1-855a-f2bfb0797f92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_0a51470a-5f37-464f-bf85-e60dbd7c8546" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d1f9ef9-89a1-438c-a072-72a3ac5a464f" xlink:to="loc_us-gaap_OtherLiabilities_0a51470a-5f37-464f-bf85-e60dbd7c8546" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_8c9c19a3-9508-424e-bd7a-d71f3aab67c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d1f9ef9-89a1-438c-a072-72a3ac5a464f" xlink:to="loc_us-gaap_LongTermDebt_8c9c19a3-9508-424e-bd7a-d71f3aab67c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_aad3cf06-a5f3-478c-981a-faec00cdeca7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_a8a748dc-a4a0-40bc-843f-f8e5522fdc90" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_aad3cf06-a5f3-478c-981a-faec00cdeca7" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_a8a748dc-a4a0-40bc-843f-f8e5522fdc90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositLiabilities_25014c11-7524-4bfb-8611-293c7021e655" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestBearingDepositLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_aad3cf06-a5f3-478c-981a-faec00cdeca7" xlink:to="loc_us-gaap_InterestBearingDepositLiabilities_25014c11-7524-4bfb-8611-293c7021e655" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmount_e8813e5a-f756-45f6-9d0c-2c0186189f95" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableNetReportedAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_acab261f-9d11-451f-8bd3-4e139c33ee37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmount_e8813e5a-f756-45f6-9d0c-2c0186189f95" xlink:to="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_acab261f-9d11-451f-8bd3-4e139c33ee37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableAllowance_77509b66-fb0e-4052-a5df-607307b197a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmount_e8813e5a-f756-45f6-9d0c-2c0186189f95" xlink:to="loc_us-gaap_LoansAndLeasesReceivableAllowance_77509b66-fb0e-4052-a5df-607307b197a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_91b19bb3-a828-41dd-b77d-43729d9c20f7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndDueFromBanks_191370cb-d705-4266-be3a-2fe2c79aadaf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndDueFromBanks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_91b19bb3-a828-41dd-b77d-43729d9c20f7" xlink:to="loc_us-gaap_CashAndDueFromBanks_191370cb-d705-4266-be3a-2fe2c79aadaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositsInBanks_8eab292e-d999-4cc5-8e13-c70c797129d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestBearingDepositsInBanks"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_91b19bb3-a828-41dd-b77d-43729d9c20f7" xlink:to="loc_us-gaap_InterestBearingDepositsInBanks_8eab292e-d999-4cc5-8e13-c70c797129d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherShortTermInvestments_a0e5b5c0-fdb3-4547-9593-bd7fd70b974c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherShortTermInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_91b19bb3-a828-41dd-b77d-43729d9c20f7" xlink:to="loc_us-gaap_OtherShortTermInvestments_a0e5b5c0-fdb3-4547-9593-bd7fd70b974c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0127ce5a-571d-4393-b432-802068302d49" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_91b19bb3-a828-41dd-b77d-43729d9c20f7" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0127ce5a-571d-4393-b432-802068302d49" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmount_da13fe34-c1b2-49b5-948a-cf7220331d86" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableNetReportedAmount"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_91b19bb3-a828-41dd-b77d-43729d9c20f7" xlink:to="loc_us-gaap_LoansAndLeasesReceivableNetReportedAmount_da13fe34-c1b2-49b5-948a-cf7220331d86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_f922e16c-e7e8-4253-8328-d25bb40fb088" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_91b19bb3-a828-41dd-b77d-43729d9c20f7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_f922e16c-e7e8-4253-8328-d25bb40fb088" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_e22d0b0e-1d54-46f0-bd05-f417fc6a4239" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_91b19bb3-a828-41dd-b77d-43729d9c20f7" xlink:to="loc_us-gaap_OtherAssets_e22d0b0e-1d54-46f0-bd05-f417fc6a4239" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_6ed237d6-afea-4eed-b4c8-5c114aa51ba5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_LoansReceivableCommercialFinancialAndAgriculturalNetOfDeferredIncome_dba74f01-693d-4b63-a51e-827e59987ace" xlink:href="cma-20211231.xsd#cma_LoansReceivableCommercialFinancialAndAgriculturalNetOfDeferredIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_6ed237d6-afea-4eed-b4c8-5c114aa51ba5" xlink:to="loc_cma_LoansReceivableCommercialFinancialAndAgriculturalNetOfDeferredIncome_dba74f01-693d-4b63-a51e-827e59987ace" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_RealEstateConstructionLoansNetOfDeferredIncome_af1000f5-ee6e-46bb-94ef-e98af6d6261f" xlink:href="cma-20211231.xsd#cma_RealEstateConstructionLoansNetOfDeferredIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_6ed237d6-afea-4eed-b4c8-5c114aa51ba5" xlink:to="loc_cma_RealEstateConstructionLoansNetOfDeferredIncome_af1000f5-ee6e-46bb-94ef-e98af6d6261f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_LoansReceivableCommercialMortgageNetOfDeferredIncome_ae916a0d-3bf5-4db8-9e94-4046a2b9181e" xlink:href="cma-20211231.xsd#cma_LoansReceivableCommercialMortgageNetOfDeferredIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_6ed237d6-afea-4eed-b4c8-5c114aa51ba5" xlink:to="loc_cma_LoansReceivableCommercialMortgageNetOfDeferredIncome_ae916a0d-3bf5-4db8-9e94-4046a2b9181e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_LoansAndLeasesReceivableConsumerMortgageNetOfDeferredIncome_c3a2969c-9e18-45bd-a66e-7c5d5dde4436" xlink:href="cma-20211231.xsd#cma_LoansAndLeasesReceivableConsumerMortgageNetOfDeferredIncome"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_6ed237d6-afea-4eed-b4c8-5c114aa51ba5" xlink:to="loc_cma_LoansAndLeasesReceivableConsumerMortgageNetOfDeferredIncome_c3a2969c-9e18-45bd-a66e-7c5d5dde4436" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_LoansAndLeasesReceivableConsumerLoansNetOfDeferredIncome_bbd8efd5-5f4a-4e84-90b7-b7517687e200" xlink:href="cma-20211231.xsd#cma_LoansAndLeasesReceivableConsumerLoansNetOfDeferredIncome"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_6ed237d6-afea-4eed-b4c8-5c114aa51ba5" xlink:to="loc_cma_LoansAndLeasesReceivableConsumerLoansNetOfDeferredIncome_bbd8efd5-5f4a-4e84-90b7-b7517687e200" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_LeasesReceivableCommercialLeaseFinancingNetOfDeferredIncome_1a71984d-80b6-4771-a32f-5955b43a61ea" xlink:href="cma-20211231.xsd#cma_LeasesReceivableCommercialLeaseFinancingNetOfDeferredIncome"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_6ed237d6-afea-4eed-b4c8-5c114aa51ba5" xlink:to="loc_cma_LeasesReceivableCommercialLeaseFinancingNetOfDeferredIncome_1a71984d-80b6-4771-a32f-5955b43a61ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_LoansAndLeasesReceivableForeignNetOfDeferredIncomeOther_dc56d730-92f8-4d04-8d98-93387b9cccfd" xlink:href="cma-20211231.xsd#cma_LoansAndLeasesReceivableForeignNetOfDeferredIncomeOther"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_6ed237d6-afea-4eed-b4c8-5c114aa51ba5" xlink:to="loc_cma_LoansAndLeasesReceivableForeignNetOfDeferredIncomeOther_dc56d730-92f8-4d04-8d98-93387b9cccfd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/ConsolidatedStatementsOfIncome" xlink:type="simple" xlink:href="cma-20211231.xsd#ConsolidatedStatementsOfIncome"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/ConsolidatedStatementsOfIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_39be2ff5-72e1-4284-b1d0-59410a988b2b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_ec97a1cb-1072-4e14-9e38-095f090efdaa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_39be2ff5-72e1-4284-b1d0-59410a988b2b" xlink:to="loc_us-gaap_InterestExpenseDeposits_ec97a1cb-1072-4e14-9e38-095f090efdaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseShortTermBorrowings_79b7585f-e2de-44e7-917b-be3903cadbf0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseShortTermBorrowings"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_39be2ff5-72e1-4284-b1d0-59410a988b2b" xlink:to="loc_us-gaap_InterestExpenseShortTermBorrowings_79b7585f-e2de-44e7-917b-be3903cadbf0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseLongTermDebt_155fea3e-b1a0-4e52-9e25-857bd01079ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseLongTermDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_39be2ff5-72e1-4284-b1d0-59410a988b2b" xlink:to="loc_us-gaap_InterestExpenseLongTermDebt_155fea3e-b1a0-4e52-9e25-857bd01079ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_cc8f3dac-047c-4ebd-84ec-62785a617e19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_be8f845f-6a10-470a-b1bf-0b6908a37ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_cc8f3dac-047c-4ebd-84ec-62785a617e19" xlink:to="loc_us-gaap_ProfitLoss_be8f845f-6a10-470a-b1bf-0b6908a37ce0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_0f753dfb-877c-4839-a162-739e9dd43faf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_cc8f3dac-047c-4ebd-84ec-62785a617e19" xlink:to="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_0f753dfb-877c-4839-a162-739e9dd43faf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_Servicechargesondepositaccounts_3d1ef1c6-3d1e-415a-8f4e-dc48150d9a5c" xlink:href="cma-20211231.xsd#cma_Servicechargesondepositaccounts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:to="loc_cma_Servicechargesondepositaccounts_3d1ef1c6-3d1e-415a-8f4e-dc48150d9a5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_Fiduciaryincome_d572b00b-ffa9-4a97-978c-2c99a2d46ed9" xlink:href="cma-20211231.xsd#cma_Fiduciaryincome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:to="loc_cma_Fiduciaryincome_d572b00b-ffa9-4a97-978c-2c99a2d46ed9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_CommercialLendingFees_86cc4242-35db-4390-88e3-797152e6502b" xlink:href="cma-20211231.xsd#cma_CommercialLendingFees"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:to="loc_cma_CommercialLendingFees_86cc4242-35db-4390-88e3-797152e6502b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_CardFees_8f6e54a9-f2bf-4cbf-949a-a1491db00116" xlink:href="cma-20211231.xsd#cma_CardFees"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:to="loc_cma_CardFees_8f6e54a9-f2bf-4cbf-949a-a1491db00116" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_LetterOfCreditFees_0f183d46-fad1-42e8-a7c3-30ad98cd7898" xlink:href="cma-20211231.xsd#cma_LetterOfCreditFees"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:to="loc_cma_LetterOfCreditFees_0f183d46-fad1-42e8-a7c3-30ad98cd7898" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsuranceIncome_93cf9edf-2cb3-490c-b11b-ff4fa42211de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BankOwnedLifeInsuranceIncome"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:to="loc_us-gaap_BankOwnedLifeInsuranceIncome_93cf9edf-2cb3-490c-b11b-ff4fa42211de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BrokerageCommissionsRevenue_86841416-37b0-4cc7-ab3b-e1c15ba0c181" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BrokerageCommissionsRevenue"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:to="loc_us-gaap_BrokerageCommissionsRevenue_86841416-37b0-4cc7-ab3b-e1c15ba0c181" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_bc0be8f7-0f99-44f5-a37c-b29eb3147514" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtAndEquitySecuritiesGainLoss"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_bc0be8f7-0f99-44f5-a37c-b29eb3147514" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_37b56233-5b97-4679-82df-db0e06890bc9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncomeOtherOperatingIncome"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_be89d924-36f4-437f-bfde-cef72b39a4e6" xlink:to="loc_us-gaap_NoninterestIncomeOtherOperatingIncome_37b56233-5b97-4679-82df-db0e06890bc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_e5fd037f-1c05-400e-b92f-af956907787e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_acddcdea-10a2-458a-b043-b78c9f574b7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_e5fd037f-1c05-400e-b92f-af956907787e" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_acddcdea-10a2-458a-b043-b78c9f574b7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_d4bfe78f-2404-4e57-9ba6-8ed4c0758f34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_e5fd037f-1c05-400e-b92f-af956907787e" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_d4bfe78f-2404-4e57-9ba6-8ed4c0758f34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_22bee90c-a102-4d50-9e23-da27a0fa4ea6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_c08f8569-6b78-4301-a324-cb36580e63cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_22bee90c-a102-4d50-9e23-da27a0fa4ea6" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_c08f8569-6b78-4301-a324-cb36580e63cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLeaseAndOtherLosses_a9bbd292-bbd3-4f1b-8b9b-47107c57a0bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanLeaseAndOtherLosses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_22bee90c-a102-4d50-9e23-da27a0fa4ea6" xlink:to="loc_us-gaap_ProvisionForLoanLeaseAndOtherLosses_a9bbd292-bbd3-4f1b-8b9b-47107c57a0bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_87a5c0b2-bc16-472c-bee8-cadffe935737" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_6d5499c0-09de-4f0e-8913-1fc7445d42bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_87a5c0b2-bc16-472c-bee8-cadffe935737" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_6d5499c0-09de-4f0e-8913-1fc7445d42bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_47bfe6e8-6536-47e1-a990-bb84c38305e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_87a5c0b2-bc16-472c-bee8-cadffe935737" xlink:to="loc_us-gaap_NoninterestIncome_47bfe6e8-6536-47e1-a990-bb84c38305e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_d7711349-fcdf-4e07-ba29-8d18198ff353" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_87a5c0b2-bc16-472c-bee8-cadffe935737" xlink:to="loc_us-gaap_NoninterestExpense_d7711349-fcdf-4e07-ba29-8d18198ff353" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_1f4399ad-2fb0-4b60-9a4f-60fbf9cfc431" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_cd7eed33-2cc4-47ec-8a1f-e0f188a60033" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_1f4399ad-2fb0-4b60-9a4f-60fbf9cfc431" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_cd7eed33-2cc4-47ec-8a1f-e0f188a60033" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_c9a25815-edbd-4828-a62a-47153f23919b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_1f4399ad-2fb0-4b60-9a4f-60fbf9cfc431" xlink:to="loc_us-gaap_InterestExpense_c9a25815-edbd-4828-a62a-47153f23919b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_41a1724e-61b9-4ac3-b50b-febc56fcbb62" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeasesHeldInPortfolio_b4889800-2bd4-4d5f-b019-efd0f44b7ee9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeasesHeldInPortfolio"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_41a1724e-61b9-4ac3-b50b-febc56fcbb62" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeasesHeldInPortfolio_b4889800-2bd4-4d5f-b019-efd0f44b7ee9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_InterestAndDividendIncomeSecuritiesAFSAndHTM_802c0565-aeda-4bf8-b653-2e335268a7f8" xlink:href="cma-20211231.xsd#cma_InterestAndDividendIncomeSecuritiesAFSAndHTM"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_41a1724e-61b9-4ac3-b50b-febc56fcbb62" xlink:to="loc_cma_InterestAndDividendIncomeSecuritiesAFSAndHTM_802c0565-aeda-4bf8-b653-2e335268a7f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherInterestAndDividendIncome_c3674f94-d84d-44de-9ab5-c20c655e23b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherInterestAndDividendIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_41a1724e-61b9-4ac3-b50b-febc56fcbb62" xlink:to="loc_us-gaap_OtherInterestAndDividendIncome_c3674f94-d84d-44de-9ab5-c20c655e23b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_595be65c-a6c3-4a59-9f6a-cf664a499dc3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_26f4f615-a1db-41fd-8c4f-7451ba4ebcd1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_595be65c-a6c3-4a59-9f6a-cf664a499dc3" xlink:to="loc_us-gaap_LaborAndRelatedExpense_26f4f615-a1db-41fd-8c4f-7451ba4ebcd1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_f4be5f24-6513-4295-a944-a9e5c9078b73" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_595be65c-a6c3-4a59-9f6a-cf664a499dc3" xlink:to="loc_us-gaap_OccupancyNet_f4be5f24-6513-4295-a944-a9e5c9078b73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentExpense_179ae1c2-e733-4bdf-85bf-e67d0cd2f923" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquipmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_595be65c-a6c3-4a59-9f6a-cf664a499dc3" xlink:to="loc_us-gaap_EquipmentExpense_179ae1c2-e733-4bdf-85bf-e67d0cd2f923" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_OutsideProcessingFeeExpense_1d3ff7ec-a034-4bcf-89e0-6b69fef633a3" xlink:href="cma-20211231.xsd#cma_OutsideProcessingFeeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_595be65c-a6c3-4a59-9f6a-cf664a499dc3" xlink:to="loc_cma_OutsideProcessingFeeExpense_1d3ff7ec-a034-4bcf-89e0-6b69fef633a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_SoftwareExpenses_57268dee-5159-4236-ad4f-71eacc6af1e9" xlink:href="cma-20211231.xsd#cma_SoftwareExpenses"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_595be65c-a6c3-4a59-9f6a-cf664a499dc3" xlink:to="loc_cma_SoftwareExpenses_57268dee-5159-4236-ad4f-71eacc6af1e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_27fccf99-510f-467d-8ad2-5f6beafc591a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalDepositInsuranceCorporationPremiumExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_595be65c-a6c3-4a59-9f6a-cf664a499dc3" xlink:to="loc_us-gaap_FederalDepositInsuranceCorporationPremiumExpense_27fccf99-510f-467d-8ad2-5f6beafc591a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvertisingExpense_da9860cb-614e-4752-bcf2-8c7eaa7304a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdvertisingExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_595be65c-a6c3-4a59-9f6a-cf664a499dc3" xlink:to="loc_us-gaap_AdvertisingExpense_da9860cb-614e-4752-bcf2-8c7eaa7304a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_133d9181-3cd9-43a3-8eb0-791ba4337997" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_595be65c-a6c3-4a59-9f6a-cf664a499dc3" xlink:to="loc_us-gaap_OtherNoninterestExpense_133d9181-3cd9-43a3-8eb0-791ba4337997" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="simple" xlink:href="cma-20211231.xsd#ConsolidatedStatementsofComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_d8d8e517-75e4-40f1-8246-3501d0cc517f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_146a07c9-5836-4000-b49b-14fae2b472d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_d8d8e517-75e4-40f1-8246-3501d0cc517f" xlink:to="loc_us-gaap_ProfitLoss_146a07c9-5836-4000-b49b-14fae2b472d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_623c8521-34e2-4e6c-be73-5ffa19bc9374" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_d8d8e517-75e4-40f1-8246-3501d0cc517f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_623c8521-34e2-4e6c-be73-5ffa19bc9374" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_e64ab9d6-0ea7-4a4d-8d30-6a6db3f6a43f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_04a7542b-18ed-4fa8-9537-041226883f89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_e64ab9d6-0ea7-4a4d-8d30-6a6db3f6a43f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_04a7542b-18ed-4fa8-9537-041226883f89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_e83b0621-e47b-4ec1-986b-50d4776e861e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_e64ab9d6-0ea7-4a4d-8d30-6a6db3f6a43f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_e83b0621-e47b-4ec1-986b-50d4776e861e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_094d9673-bcf6-4282-8733-20940cdb3505" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_cb0e4330-21ec-41ae-a26c-df3828604f54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_094d9673-bcf6-4282-8733-20940cdb3505" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_cb0e4330-21ec-41ae-a26c-df3828604f54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_262e1413-a1ea-457f-98d8-5584f3c4b1b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_094d9673-bcf6-4282-8733-20940cdb3505" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_262e1413-a1ea-457f-98d8-5584f3c4b1b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_70d612fa-564f-4fed-ba0e-5c09ae36fee0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_055473a4-7ac5-4385-806e-7727b9043c9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_70d612fa-564f-4fed-ba0e-5c09ae36fee0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_055473a4-7ac5-4385-806e-7727b9043c9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_2a2c608b-f4fb-44e3-b64f-4cacd658e395" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_f21114b6-74ea-4246-9cc5-3b9b310d026d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_2a2c608b-f4fb-44e3-b64f-4cacd658e395" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_f21114b6-74ea-4246-9cc5-3b9b310d026d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_385cac5a-ce9f-41ae-8cab-d292174b390c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_2a2c608b-f4fb-44e3-b64f-4cacd658e395" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_385cac5a-ce9f-41ae-8cab-d292174b390c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="simple" xlink:href="cma-20211231.xsd#ConsolidatedStatementsOfCashFlows"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_deb29561-3100-40fd-ba69-7c7279812397" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:to="loc_us-gaap_ProfitLoss_deb29561-3100-40fd-ba69-7c7279812397" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLeaseAndOtherLosses_d5eb8ec8-63ef-45d9-8ce5-5d9e7baff09a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanLeaseAndOtherLosses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:to="loc_us-gaap_ProvisionForLoanLeaseAndOtherLosses_d5eb8ec8-63ef-45d9-8ce5-5d9e7baff09a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_319167c8-6a14-48e8-b07c-3e0ee891bfff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_319167c8-6a14-48e8-b07c-3e0ee891bfff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_ea0e9193-4f58-4053-99fd-ed3f1ae6aaa8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:to="loc_us-gaap_DepreciationAndAmortization_ea0e9193-4f58-4053-99fd-ed3f1ae6aaa8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_1822682f-5830-4e31-9ee1-7861d702f6ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_1822682f-5830-4e31-9ee1-7861d702f6ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_6e74a42d-8ae6-497b-bfeb-295c695eda56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:to="loc_us-gaap_ShareBasedCompensation_6e74a42d-8ae6-497b-bfeb-295c695eda56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_1bdbc403-c793-4050-8c55-3cf1226363a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_1bdbc403-c793-4050-8c55-3cf1226363a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_27774fd7-dc50-428f-a6ad-323692d51acd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_27774fd7-dc50-428f-a6ad-323692d51acd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_cd7fd087-83fa-455d-a902-2d1a67486c3d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9bfd24bb-c855-47bf-bc29-2a312d923ced" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_cd7fd087-83fa-455d-a902-2d1a67486c3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_8eabfaae-542e-4fe8-88d8-097522de8ae8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_8eabfaae-542e-4fe8-88d8-097522de8ae8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireFederalHomeLoanBankStock_2778b1fe-9137-40fb-8b57-ab679c2a8b4a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireFederalHomeLoanBankStock"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:to="loc_us-gaap_PaymentsToAcquireFederalHomeLoanBankStock_2778b1fe-9137-40fb-8b57-ab679c2a8b4a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfFederalHomeLoanBankStock_1516a71e-f928-47cb-9396-94cbb9ba1d73" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfFederalHomeLoanBankStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:to="loc_us-gaap_ProceedsFromSaleOfFederalHomeLoanBankStock_1516a71e-f928-47cb-9396-94cbb9ba1d73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_5c096938-bdc1-4b3b-8bf6-45f541e3df66" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_5c096938-bdc1-4b3b-8bf6-45f541e3df66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_141a57c9-c551-47ce-a7f0-fb7bae3fd7ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_141a57c9-c551-47ce-a7f0-fb7bae3fd7ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromLoansAndLeases_62dfbd59-a97f-44b1-9480-e525b023310d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForProceedsFromLoansAndLeases"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:to="loc_us-gaap_PaymentsForProceedsFromLoansAndLeases_62dfbd59-a97f-44b1-9480-e525b023310d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfForeclosedAssets_afa4382a-5d8e-491b-b314-3d398f2f415e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfForeclosedAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:to="loc_us-gaap_ProceedsFromSaleOfForeclosedAssets_afa4382a-5d8e-491b-b314-3d398f2f415e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_NetIncreaseInFixedAssets_79f83c8a-0a57-47b5-a355-a822db54fa43" xlink:href="cma-20211231.xsd#cma_NetIncreaseInFixedAssets"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:to="loc_cma_NetIncreaseInFixedAssets_79f83c8a-0a57-47b5-a355-a822db54fa43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLifeInsurancePolicies_d9efafde-ec3f-40d9-af56-327c7cc42cee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromLifeInsurancePolicies"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cbf0cff-9939-4c24-8458-78c33cb18393" xlink:to="loc_us-gaap_ProceedsFromLifeInsurancePolicies_d9efafde-ec3f-40d9-af56-327c7cc42cee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acc4590a-e596-4b6d-996d-c6d196695a38" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeposits_ebd0ff0c-ed7c-4b60-90c7-d773e4f35524" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acc4590a-e596-4b6d-996d-c6d196695a38" xlink:to="loc_us-gaap_IncreaseDecreaseInDeposits_ebd0ff0c-ed7c-4b60-90c7-d773e4f35524" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_80eb2846-668e-4e65-9036-31c8aa877a40" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acc4590a-e596-4b6d-996d-c6d196695a38" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_80eb2846-668e-4e65-9036-31c8aa877a40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_4b345bbf-d2af-4e6d-88a3-237fa5d91e96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acc4590a-e596-4b6d-996d-c6d196695a38" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_4b345bbf-d2af-4e6d-88a3-237fa5d91e96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_b29c167a-b629-4b89-963c-f39aac829593" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acc4590a-e596-4b6d-996d-c6d196695a38" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_b29c167a-b629-4b89-963c-f39aac829593" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_eacd3bd6-7937-4848-8f53-61f309e49cbe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acc4590a-e596-4b6d-996d-c6d196695a38" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_eacd3bd6-7937-4848-8f53-61f309e49cbe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_09883eae-29f3-4593-bf27-d2ef5433a836" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividendsCommonStock"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acc4590a-e596-4b6d-996d-c6d196695a38" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_09883eae-29f3-4593-bf27-d2ef5433a836" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_ad9e045d-f39c-4b5d-bb9f-3365936fd035" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acc4590a-e596-4b6d-996d-c6d196695a38" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_ad9e045d-f39c-4b5d-bb9f-3365936fd035" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_51cad6e8-8b6a-4599-bd99-7aebcd1627e0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fed1967e-c724-4c52-8563-1ab2eb2abcb6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_51cad6e8-8b6a-4599-bd99-7aebcd1627e0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fed1967e-c724-4c52-8563-1ab2eb2abcb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_13475697-646a-4d9b-be5b-39bce573ff4f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_51cad6e8-8b6a-4599-bd99-7aebcd1627e0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_13475697-646a-4d9b-be5b-39bce573ff4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65366689-2d12-4bc2-b2bb-98f646899256" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_51cad6e8-8b6a-4599-bd99-7aebcd1627e0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_65366689-2d12-4bc2-b2bb-98f646899256" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/InvestmentSecuritiesSummaryOfInvestmentSecuritiesInUnrealizedLossPositionsDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#InvestmentSecuritiesSummaryOfInvestmentSecuritiesInUnrealizedLossPositionsDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/InvestmentSecuritiesSummaryOfInvestmentSecuritiesInUnrealizedLossPositionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_2a533f04-e394-443a-ab97-55347b83ec5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_7e814ef6-95c5-4e46-a9d3-4e2a7d3dc4fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_2a533f04-e394-443a-ab97-55347b83ec5b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_7e814ef6-95c5-4e46-a9d3-4e2a7d3dc4fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_3e77d7d5-cebc-4340-acaf-6f04e1adbf57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_2a533f04-e394-443a-ab97-55347b83ec5b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_3e77d7d5-cebc-4340-acaf-6f04e1adbf57" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/CreditQualityAndAllowanceForCreditLossesAgingAnalysisOfLoansDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#CreditQualityAndAllowanceForCreditLossesAgingAnalysisOfLoansDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/CreditQualityAndAllowanceForCreditLossesAgingAnalysisOfLoansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_becba70d-cbac-4c13-b521-f6318e5a1418" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_LoansPastDueAndStillAccruing_a33a16df-3dab-4434-a160-7153bfb74bff" xlink:href="cma-20211231.xsd#cma_LoansPastDueAndStillAccruing"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_becba70d-cbac-4c13-b521-f6318e5a1418" xlink:to="loc_cma_LoansPastDueAndStillAccruing_a33a16df-3dab-4434-a160-7153bfb74bff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansAndLeasesReceivableImpairedNonperformingNonaccrualOfInterest_20c887f8-4288-406b-89ce-37be498b1a9e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LoansAndLeasesReceivableImpairedNonperformingNonaccrualOfInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_becba70d-cbac-4c13-b521-f6318e5a1418" xlink:to="loc_us-gaap_LoansAndLeasesReceivableImpairedNonperformingNonaccrualOfInterest_20c887f8-4288-406b-89ce-37be498b1a9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_CurrentLoans_f90ab33f-f1fd-41ae-96e8-5f51d0abd7c8" xlink:href="cma-20211231.xsd#cma_CurrentLoans"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_becba70d-cbac-4c13-b521-f6318e5a1418" xlink:to="loc_cma_CurrentLoans_f90ab33f-f1fd-41ae-96e8-5f51d0abd7c8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/CreditQualityAndAllowanceForCreditLossesChangesInTheAllowanceForLoanLossesAndRelatedLoanAmountsDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#CreditQualityAndAllowanceForCreditLossesChangesInTheAllowanceForLoanLossesAndRelatedLoanAmountsDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/CreditQualityAndAllowanceForCreditLossesChangesInTheAllowanceForLoanLossesAndRelatedLoanAmountsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet_18730c97-99e3-411c-a67c-95e3088ea922" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_d4d8dff9-7508-4cb7-a080-58d9ec252e88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet_18730c97-99e3-411c-a67c-95e3088ea922" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_d4d8dff9-7508-4cb7-a080-58d9ec252e88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery_5d48dc60-1cca-49b6-ba4d-3726c754f15b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet_18730c97-99e3-411c-a67c-95e3088ea922" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery_5d48dc60-1cca-49b6-ba4d-3726c754f15b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/DepositsDepositsScheduleofMaturitiesofCertificatesofDepositandOtherDepositswithaStatedMaturityDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#DepositsDepositsScheduleofMaturitiesofCertificatesofDepositandOtherDepositswithaStatedMaturityDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/DepositsDepositsScheduleofMaturitiesofCertificatesofDepositandOtherDepositswithaStatedMaturityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDeposits_6dfee593-4a4a-429a-a40f-d33c27655746" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDeposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_27853455-1686-4536-85a5-42d29fb9d012" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_6dfee593-4a4a-429a-a40f-d33c27655746" xlink:to="loc_us-gaap_TimeDepositMaturitiesNextRollingTwelveMonths_27853455-1686-4536-85a5-42d29fb9d012" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearTwo_1cc2d4b8-6014-4be8-b78f-eb8bbe45fd1f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDepositMaturitiesYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_6dfee593-4a4a-429a-a40f-d33c27655746" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearTwo_1cc2d4b8-6014-4be8-b78f-eb8bbe45fd1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearThree_19fa7229-8f39-4ba2-b675-1c663ad4c135" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDepositMaturitiesYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_6dfee593-4a4a-429a-a40f-d33c27655746" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearThree_19fa7229-8f39-4ba2-b675-1c663ad4c135" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearFour_64d73db8-b26c-4233-8f97-3f4bdb7c680f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDepositMaturitiesYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_6dfee593-4a4a-429a-a40f-d33c27655746" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearFour_64d73db8-b26c-4233-8f97-3f4bdb7c680f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesYearFive_5f38a8a2-024a-4f87-9c7a-7079eac1c23e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDepositMaturitiesYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_6dfee593-4a4a-429a-a40f-d33c27655746" xlink:to="loc_us-gaap_TimeDepositMaturitiesYearFive_5f38a8a2-024a-4f87-9c7a-7079eac1c23e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositMaturitiesAfterYearFive_c868ad5c-0ce8-4a26-8758-124f34b07b53" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TimeDepositMaturitiesAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_TimeDeposits_6dfee593-4a4a-429a-a40f-d33c27655746" xlink:to="loc_us-gaap_TimeDepositMaturitiesAfterYearFive_c868ad5c-0ce8-4a26-8758-124f34b07b53" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/AccumulatedOtherComprehensiveLossScheduleOfAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#AccumulatedOtherComprehensiveLossScheduleOfAccumulatedOtherComprehensiveIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/AccumulatedOtherComprehensiveLossScheduleOfAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_cded8ad3-45fc-4431-a3a2-a7246c59ca08" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_43d11fb5-a537-4447-afe7-c59356d82d64" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_cded8ad3-45fc-4431-a3a2-a7246c59ca08" xlink:to="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_43d11fb5-a537-4447-afe7-c59356d82d64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostNetOfTax_e0a0b4cd-994f-4d03-a8a0-0097736d0efa" xlink:href="cma-20211231.xsd#cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_cded8ad3-45fc-4431-a3a2-a7246c59ca08" xlink:to="loc_cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostNetOfTax_e0a0b4cd-994f-4d03-a8a0-0097736d0efa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_123ad02f-4d05-44b7-989a-d299259463d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_329bd30d-fe3d-4160-9ec1-8affc3b5ecf4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_123ad02f-4d05-44b7-989a-d299259463d5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodTax_329bd30d-fe3d-4160-9ec1-8affc3b5ecf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostNetOfTax_31c660fd-e129-40ec-b783-c9f74182f51f" xlink:href="cma-20211231.xsd#cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostBeforeTax_024f4394-6cc9-4a0b-bdb7-9d2e46e16806" xlink:href="cma-20211231.xsd#cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostNetOfTax_31c660fd-e129-40ec-b783-c9f74182f51f" xlink:to="loc_cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostBeforeTax_024f4394-6cc9-4a0b-bdb7-9d2e46e16806" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_0373d303-8199-4509-b6d5-165791da36bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_83bb5d12-09e4-4f05-b650-e2f97de78eb1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_0373d303-8199-4509-b6d5-165791da36bc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_83bb5d12-09e4-4f05-b650-e2f97de78eb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_93a50332-909e-4088-84f3-ff839e57969e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_0373d303-8199-4509-b6d5-165791da36bc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_93a50332-909e-4088-84f3-ff839e57969e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_2d63b6fb-bd20-4887-aae6-097ac5e2c101" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_79ec151b-541d-4a48-8a66-7a5aef834ceb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_2d63b6fb-bd20-4887-aae6-097ac5e2c101" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesBeforeTax_79ec151b-541d-4a48-8a66-7a5aef834ceb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_1d724b8d-7321-4677-aa66-dceecb239365" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_2d63b6fb-bd20-4887-aae6-097ac5e2c101" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesTax_1d724b8d-7321-4677-aa66-dceecb239365" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostBeforeTax_16512a52-0afb-4046-b738-88b92f2b9d42" xlink:href="cma-20211231.xsd#cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_3cadc15d-f82e-49cd-b684-0f8acddab2fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostBeforeTax_16512a52-0afb-4046-b738-88b92f2b9d42" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_3cadc15d-f82e-49cd-b684-0f8acddab2fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_bdcffaee-a90d-45f4-bc63-316e2286628b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_OtherComprehensiveIncomeLossReclassificationAdjustmentPensionAndOtherPostretirementBenefitPlansRecognizedInNetPeriodicDefinedBenefitCostBeforeTax_16512a52-0afb-4046-b738-88b92f2b9d42" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_bdcffaee-a90d-45f4-bc63-316e2286628b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_fefc8a9b-8dff-4243-8115-0e65135cc227" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_16724c43-7c5d-466c-95db-7105a7339c1a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_fefc8a9b-8dff-4243-8115-0e65135cc227" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_16724c43-7c5d-466c-95db-7105a7339c1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_b2a46490-c170-4cc2-b2f9-eecd3bccee7f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_fefc8a9b-8dff-4243-8115-0e65135cc227" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_b2a46490-c170-4cc2-b2f9-eecd3bccee7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_59daa38c-26d6-4e75-93a3-279425d2da05" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodTax_84884900-292a-401c-b2ec-feafaa3576af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_59daa38c-26d6-4e75-93a3-279425d2da05" xlink:to="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodTax_84884900-292a-401c-b2ec-feafaa3576af" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/EmployeeBenefitPlansReconciliationsofPlanassetsandtheProjectedBenefitObligationtheWeightedAverageAssumptionsUsedtoDetermineYearEndBenefitObligationsandtheAmountsRecognizedinAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#EmployeeBenefitPlansReconciliationsofPlanassetsandtheProjectedBenefitObligationtheWeightedAverageAssumptionsUsedtoDetermineYearEndBenefitObligationsandtheAmountsRecognizedinAccumulatedOtherComprehensiveIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/EmployeeBenefitPlansReconciliationsofPlanassetsandtheProjectedBenefitObligationtheWeightedAverageAssumptionsUsedtoDetermineYearEndBenefitObligationsandtheAmountsRecognizedinAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_c81a0244-a63d-40fa-a078-2e41650ee16f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_c5fe5f37-cc43-4a81-ac65-2746a9bb23b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_c81a0244-a63d-40fa-a078-2e41650ee16f" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_c5fe5f37-cc43-4a81-ac65-2746a9bb23b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_c9085bda-a27c-4389-8e02-aaa61e8f9224" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_c81a0244-a63d-40fa-a078-2e41650ee16f" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_c9085bda-a27c-4389-8e02-aaa61e8f9224" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/EmployeeBenefitPlansEmployeeBenefitPlansNetPeriodicDefinedBenefitCostDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#EmployeeBenefitPlansEmployeeBenefitPlansNetPeriodicDefinedBenefitCostDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/EmployeeBenefitPlansEmployeeBenefitPlansNetPeriodicDefinedBenefitCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cma_Totalothercomponentsofnetbenefitcreditorcost_5f7f2abc-5812-42ac-a2b1-0e49973813b9" xlink:href="cma-20211231.xsd#cma_Totalothercomponentsofnetbenefitcreditorcost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_7cec35c8-a464-4a7a-991e-07b566b06c16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_Totalothercomponentsofnetbenefitcreditorcost_5f7f2abc-5812-42ac-a2b1-0e49973813b9" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_7cec35c8-a464-4a7a-991e-07b566b06c16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_ea29a1d0-ecbc-4e6d-835f-5ed5d566d81a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_Totalothercomponentsofnetbenefitcreditorcost_5f7f2abc-5812-42ac-a2b1-0e49973813b9" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_ea29a1d0-ecbc-4e6d-835f-5ed5d566d81a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_7b92a939-59ce-4909-b6cf-c84706379e69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_Totalothercomponentsofnetbenefitcreditorcost_5f7f2abc-5812-42ac-a2b1-0e49973813b9" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_7b92a939-59ce-4909-b6cf-c84706379e69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_5798e23a-6401-49a0-b482-761b3362c305" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_Totalothercomponentsofnetbenefitcreditorcost_5f7f2abc-5812-42ac-a2b1-0e49973813b9" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_5798e23a-6401-49a0-b482-761b3362c305" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_a0a7adbd-f1b5-4a20-84b1-996c18a55470" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_29d6d3a0-9a52-498b-9cf0-4b850ba04d63" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_a0a7adbd-f1b5-4a20-84b1-996c18a55470" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_29d6d3a0-9a52-498b-9cf0-4b850ba04d63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_7ca50166-2857-4f62-b747-fd2a52058015" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_a0a7adbd-f1b5-4a20-84b1-996c18a55470" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_7ca50166-2857-4f62-b747-fd2a52058015" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_4e8e61d7-7d59-4006-a126-b20a56b23a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_a0a7adbd-f1b5-4a20-84b1-996c18a55470" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_4e8e61d7-7d59-4006-a126-b20a56b23a0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_7f011608-f660-4030-932c-602cea31714b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_a0a7adbd-f1b5-4a20-84b1-996c18a55470" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_7f011608-f660-4030-932c-602cea31714b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_fb0da107-fd99-4693-84f5-563764a111ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_a0a7adbd-f1b5-4a20-84b1-996c18a55470" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_fb0da107-fd99-4693-84f5-563764a111ed" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/ParentCompanyFinancialStatementsParentCompanyFinancialStatementsBalanceSheetsDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#ParentCompanyFinancialStatementsParentCompanyFinancialStatementsBalanceSheetsDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/ParentCompanyFinancialStatementsParentCompanyFinancialStatementsBalanceSheetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_14c98960-0b56-4bd9-ad45-dd60909a776b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherShortTermInvestments_d1a7f366-19ad-4618-9e72-5317fd97851c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherShortTermInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_14c98960-0b56-4bd9-ad45-dd60909a776b" xlink:to="loc_us-gaap_OtherShortTermInvestments_d1a7f366-19ad-4618-9e72-5317fd97851c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_InvestmentsInMajorityOwnedConsolidatedSubsidiaries_bd6c3ba5-254c-4270-8330-83f44bd8c02b" xlink:href="cma-20211231.xsd#cma_InvestmentsInMajorityOwnedConsolidatedSubsidiaries"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_14c98960-0b56-4bd9-ad45-dd60909a776b" xlink:to="loc_cma_InvestmentsInMajorityOwnedConsolidatedSubsidiaries_bd6c3ba5-254c-4270-8330-83f44bd8c02b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_3020d7a1-598c-4ac0-aa32-65cde790feb9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_14c98960-0b56-4bd9-ad45-dd60909a776b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_3020d7a1-598c-4ac0-aa32-65cde790feb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_71be7323-d052-45b4-a79b-a894f22530e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_14c98960-0b56-4bd9-ad45-dd60909a776b" xlink:to="loc_us-gaap_OtherAssets_71be7323-d052-45b4-a79b-a894f22530e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndDueFromBanks_9c678140-2366-4ac0-b63c-1f5209f3181f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndDueFromBanks"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_14c98960-0b56-4bd9-ad45-dd60909a776b" xlink:to="loc_us-gaap_CashAndDueFromBanks_9c678140-2366-4ac0-b63c-1f5209f3181f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_158629c0-6c7d-428b-b434-7cdeb59f93d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_de40a6b6-d522-43f2-ae70-da5b35832a3d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_158629c0-6c7d-428b-b434-7cdeb59f93d4" xlink:to="loc_us-gaap_Liabilities_de40a6b6-d522-43f2-ae70-da5b35832a3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_02486e34-7d48-4f42-9aa9-4e734b72226d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_158629c0-6c7d-428b-b434-7cdeb59f93d4" xlink:to="loc_us-gaap_CommonStockValue_02486e34-7d48-4f42-9aa9-4e734b72226d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_ef747820-727f-4fee-bf89-e59bc576a81e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_158629c0-6c7d-428b-b434-7cdeb59f93d4" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_ef747820-727f-4fee-bf89-e59bc576a81e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_8d90abf9-3de2-4e19-afad-2892b31eb13d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_158629c0-6c7d-428b-b434-7cdeb59f93d4" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_8d90abf9-3de2-4e19-afad-2892b31eb13d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_91f9cd2d-fd83-4f00-9134-14066707e98e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_158629c0-6c7d-428b-b434-7cdeb59f93d4" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_91f9cd2d-fd83-4f00-9134-14066707e98e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_1480feab-94e5-4d58-8aae-c0f4205dbdd0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_158629c0-6c7d-428b-b434-7cdeb59f93d4" xlink:to="loc_us-gaap_TreasuryStockValue_1480feab-94e5-4d58-8aae-c0f4205dbdd0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_6394523f-4f05-4073-b7fa-fa585e44ffe4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_f2ea4f1b-b1ff-4921-a957-88e0466edd77" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_6394523f-4f05-4073-b7fa-fa585e44ffe4" xlink:to="loc_us-gaap_LongTermDebt_f2ea4f1b-b1ff-4921-a957-88e0466edd77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_986d0448-64bc-4039-a08d-7874d9a38e0c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_6394523f-4f05-4073-b7fa-fa585e44ffe4" xlink:to="loc_us-gaap_OtherLiabilities_986d0448-64bc-4039-a08d-7874d9a38e0c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/ParentCompanyFinancialStatementsParentCompanyFinancialStatementsStatementsofIncomeDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#ParentCompanyFinancialStatementsParentCompanyFinancialStatementsStatementsofIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/ParentCompanyFinancialStatementsParentCompanyFinancialStatementsStatementsofIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cma_IncomeLossFromContinuingOperationsBeforeMinorityInterestsAndIncomeLossFromEquityMethodInvestments_8df4948f-087e-4703-9355-b3eaace9872c" xlink:href="cma-20211231.xsd#cma_IncomeLossFromContinuingOperationsBeforeMinorityInterestsAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_82c7e1ff-33fc-464b-9852-ee8a3c6cc0c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_IncomeLossFromContinuingOperationsBeforeMinorityInterestsAndIncomeLossFromEquityMethodInvestments_8df4948f-087e-4703-9355-b3eaace9872c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_82c7e1ff-33fc-464b-9852-ee8a3c6cc0c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_44b1664c-a6f2-4418-aeca-1531a5875824" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_IncomeLossFromContinuingOperationsBeforeMinorityInterestsAndIncomeLossFromEquityMethodInvestments_8df4948f-087e-4703-9355-b3eaace9872c" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_44b1664c-a6f2-4418-aeca-1531a5875824" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_53196229-5c1a-4621-9977-9360cfa63876" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashDividendsPaidToParentCompanyByConsolidatedSubsidiaries_ced9d952-0056-4506-af7d-6e60ae66931f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashDividendsPaidToParentCompanyByConsolidatedSubsidiaries"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_53196229-5c1a-4621-9977-9360cfa63876" xlink:to="loc_us-gaap_CashDividendsPaidToParentCompanyByConsolidatedSubsidiaries_ced9d952-0056-4506-af7d-6e60ae66931f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherInterestAndDividendIncome_9400bc22-c5e1-4c9d-b56f-f0ee54a6fc57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherInterestAndDividendIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_53196229-5c1a-4621-9977-9360cfa63876" xlink:to="loc_us-gaap_OtherInterestAndDividendIncome_9400bc22-c5e1-4c9d-b56f-f0ee54a6fc57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_IntercompanyManagementFee_2fc512cf-8870-43d9-9dcb-57913dc5ae66" xlink:href="cma-20211231.xsd#cma_IntercompanyManagementFee"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_53196229-5c1a-4621-9977-9360cfa63876" xlink:to="loc_cma_IntercompanyManagementFee_2fc512cf-8870-43d9-9dcb-57913dc5ae66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_3bb86bc6-cc89-438e-acd4-49e90de216d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_b2bf3117-1c71-4196-b068-25df1f2a1152" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_3bb86bc6-cc89-438e-acd4-49e90de216d0" xlink:to="loc_us-gaap_Revenues_b2bf3117-1c71-4196-b068-25df1f2a1152" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_46903c86-3a69-4894-be36-1dcfc6698ec6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_3bb86bc6-cc89-438e-acd4-49e90de216d0" xlink:to="loc_us-gaap_CostsAndExpenses_46903c86-3a69-4894-be36-1dcfc6698ec6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_1f2c3a99-865b-4904-90da-90c9c9c84bf2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseLongTermDebt_a861215f-9df5-45b4-b2c7-4fb5f81ead42" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseLongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_1f2c3a99-865b-4904-90da-90c9c9c84bf2" xlink:to="loc_us-gaap_InterestExpenseLongTermDebt_a861215f-9df5-45b4-b2c7-4fb5f81ead42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_c00b5b9f-4162-41a2-af18-905e66a26feb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_1f2c3a99-865b-4904-90da-90c9c9c84bf2" xlink:to="loc_us-gaap_LaborAndRelatedExpense_c00b5b9f-4162-41a2-af18-905e66a26feb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_58c107b6-266d-4203-b4b9-f71104e4148a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_1f2c3a99-865b-4904-90da-90c9c9c84bf2" xlink:to="loc_us-gaap_OtherNoninterestExpense_58c107b6-266d-4203-b4b9-f71104e4148a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_8c7d5a3d-522d-4035-a732-2a932bee53fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_IncomeLossFromContinuingOperationsBeforeMinorityInterestsAndIncomeLossFromEquityMethodInvestments_2c7c40d2-29a5-4532-b8ff-2ee4923ca975" xlink:href="cma-20211231.xsd#cma_IncomeLossFromContinuingOperationsBeforeMinorityInterestsAndIncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_8c7d5a3d-522d-4035-a732-2a932bee53fb" xlink:to="loc_cma_IncomeLossFromContinuingOperationsBeforeMinorityInterestsAndIncomeLossFromEquityMethodInvestments_2c7c40d2-29a5-4532-b8ff-2ee4923ca975" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_acc31cab-3f66-4fe5-a3c1-893f144d6fe9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_8c7d5a3d-522d-4035-a732-2a932bee53fb" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_acc31cab-3f66-4fe5-a3c1-893f144d6fe9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/SummaryofQuarterlyFinancialStatementsUnauditedSummaryofQuarterlyFinancialStatementsUnauditedSummaryofQuarterlyFinancialStatementsDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#SummaryofQuarterlyFinancialStatementsUnauditedSummaryofQuarterlyFinancialStatementsUnauditedSummaryofQuarterlyFinancialStatementsDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/SummaryofQuarterlyFinancialStatementsUnauditedSummaryofQuarterlyFinancialStatementsUnauditedSummaryofQuarterlyFinancialStatementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_439e1d8e-71ac-46b6-b03b-dff8d9872189" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_557841bb-a576-4285-9bf5-e581038beaea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_439e1d8e-71ac-46b6-b03b-dff8d9872189" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_557841bb-a576-4285-9bf5-e581038beaea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLeaseAndOtherLosses_bcbdefb0-4f23-4853-bda6-c5f1fedd010f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForLoanLeaseAndOtherLosses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_439e1d8e-71ac-46b6-b03b-dff8d9872189" xlink:to="loc_us-gaap_ProvisionForLoanLeaseAndOtherLosses_bcbdefb0-4f23-4853-bda6-c5f1fedd010f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_6e415be7-c0a0-4d6c-b081-8d34ad42b2c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtAndEquitySecuritiesGainLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_439e1d8e-71ac-46b6-b03b-dff8d9872189" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_6e415be7-c0a0-4d6c-b081-8d34ad42b2c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_NonInterestIncomeExcludingNetSecuritiesGains_f695abfe-5af9-4a30-b9e8-ea4166a82a74" xlink:href="cma-20211231.xsd#cma_NonInterestIncomeExcludingNetSecuritiesGains"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_439e1d8e-71ac-46b6-b03b-dff8d9872189" xlink:to="loc_cma_NonInterestIncomeExcludingNetSecuritiesGains_f695abfe-5af9-4a30-b9e8-ea4166a82a74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_179e4bc9-e4c5-455e-aab5-db1ddec676d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_439e1d8e-71ac-46b6-b03b-dff8d9872189" xlink:to="loc_us-gaap_NoninterestExpense_179e4bc9-e4c5-455e-aab5-db1ddec676d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_d92ecf8f-a709-4e65-915e-8ec1d97e071b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_439e1d8e-71ac-46b6-b03b-dff8d9872189" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_d92ecf8f-a709-4e65-915e-8ec1d97e071b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/RevenuefromContractswithCustomersRevenuefromContractswithCustomersDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#RevenuefromContractswithCustomersRevenuefromContractswithCustomersDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/RevenuefromContractswithCustomersRevenuefromContractswithCustomersDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_CardFees_140c0a43-2ba4-4cd0-b825-d154d3b60623" xlink:href="cma-20211231.xsd#cma_CardFees"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:to="loc_cma_CardFees_140c0a43-2ba4-4cd0-b825-d154d3b60623" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_Servicechargesondepositaccounts_6e561f5c-c2e6-44d4-82ed-45bb92a87683" xlink:href="cma-20211231.xsd#cma_Servicechargesondepositaccounts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:to="loc_cma_Servicechargesondepositaccounts_6e561f5c-c2e6-44d4-82ed-45bb92a87683" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_Fiduciaryincome_eceae66e-f9bc-4b9c-8365-51d64b4e489a" xlink:href="cma-20211231.xsd#cma_Fiduciaryincome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:to="loc_cma_Fiduciaryincome_eceae66e-f9bc-4b9c-8365-51d64b4e489a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_CommercialLendingFees_3b8b3545-18db-45bb-952e-7b6d4d9e3012" xlink:href="cma-20211231.xsd#cma_CommercialLendingFees"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:to="loc_cma_CommercialLendingFees_3b8b3545-18db-45bb-952e-7b6d4d9e3012" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_LetterOfCreditFees_1bd9ea18-bb65-4a22-8964-a91139444513" xlink:href="cma-20211231.xsd#cma_LetterOfCreditFees"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:to="loc_cma_LetterOfCreditFees_1bd9ea18-bb65-4a22-8964-a91139444513" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankOwnedLifeInsuranceIncome_14ba1e70-becc-4828-9b22-ae49dd45db09" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BankOwnedLifeInsuranceIncome"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:to="loc_us-gaap_BankOwnedLifeInsuranceIncome_14ba1e70-becc-4828-9b22-ae49dd45db09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BrokerageCommissionsRevenue_eb04fed2-e2da-42af-ac14-d648077b5e4e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BrokerageCommissionsRevenue"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:to="loc_us-gaap_BrokerageCommissionsRevenue_eb04fed2-e2da-42af-ac14-d648077b5e4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cma_Othersourcesofnoninterestincome_e470161e-59a2-45bb-bd2a-8ab602047521" xlink:href="cma-20211231.xsd#cma_Othersourcesofnoninterestincome"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:to="loc_cma_Othersourcesofnoninterestincome_e470161e-59a2-45bb-bd2a-8ab602047521" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_45462071-bb32-4a04-9196-a3007aa94f77" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_68a874cc-98f8-44b8-b0d4-bc835f335c94" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_45462071-bb32-4a04-9196-a3007aa94f77" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.comerica.com/role/LeasesContractualMaturitiesofOperatingLeaseLiabilitiesDetailsDetails" xlink:type="simple" xlink:href="cma-20211231.xsd#LeasesContractualMaturitiesofOperatingLeaseLiabilitiesDetailsDetails"/>
  <link:calculationLink xlink:role="http://www.comerica.com/role/LeasesContractualMaturitiesofOperatingLeaseLiabilitiesDetailsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cma_LesseeOperatingLeaseLiabilityToBePaidLessInterest_07d0741f-6b49-4244-8eb8-5d942c4b1315" xlink:href="cma-20211231.xsd#cma_LesseeOperatingLeaseLiabilityToBePaidLessInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_dd2c3698-6014-4d05-9dd4-4cb5e03242e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_LesseeOperatingLeaseLiabilityToBePaidLessInterest_07d0741f-6b49-4244-8eb8-5d942c4b1315" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_dd2c3698-6014-4d05-9dd4-4cb5e03242e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrentAndNoncurrent_14c13bfd-17b4-4040-adcc-9a5bf237aa46" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestPayableCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cma_LesseeOperatingLeaseLiabilityToBePaidLessInterest_07d0741f-6b49-4244-8eb8-5d942c4b1315" xlink:to="loc_us-gaap_InterestPayableCurrentAndNoncurrent_14c13bfd-17b4-4040-adcc-9a5bf237aa46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_76ddac9d-a5fa-441f-bd77-5dbdaf8e08a4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_733a7a4c-7e5e-4e94-89a4-53c3e9a9d8e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_76ddac9d-a5fa-441f-bd77-5dbdaf8e08a4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_733a7a4c-7e5e-4e94-89a4-53c3e9a9d8e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_3f7d91c0-1404-4ad7-881d-f5cbe3874094" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_76ddac9d-a5fa-441f-bd77-5dbdaf8e08a4" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_3f7d91c0-1404-4ad7-881d-f5cbe3874094" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_5493633e-b75e-4ddd-9de5-768eb57ee003" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_76ddac9d-a5fa-441f-bd77-5dbdaf8e08a4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_5493633e-b75e-4ddd-9de5-768eb57ee003" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_e47c7523-d5ea-48dc-895d-59be3080684b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_76ddac9d-a5fa-441f-bd77-5dbdaf8e08a4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_e47c7523-d5ea-48dc-895d-59be3080684b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_169ff7c1-7e4e-4775-befc-aab038cfda5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_76ddac9d-a5fa-441f-bd77-5dbdaf8e08a4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_169ff7c1-7e4e-4775-befc-aab038cfda5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_6e4ded65-0fc8-4546-8ed2-5f40dca5127c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_76ddac9d-a5fa-441f-bd77-5dbdaf8e08a4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_6e4ded65-0fc8-4546-8ed2-5f40dca5127c" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
