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  <xs:element id="onb_CoreDepositsAndOtherIntangibleAssetsMember" abstract="true" name="CoreDepositsAndOtherIntangibleAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" abstract="false" name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_LowIncomeHousingTaxCreditsMember" abstract="true" name="LowIncomeHousingTaxCreditsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_FederalHistoricTaxCreditsMember" abstract="true" name="FederalHistoricTaxCreditsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_NewMarketsTaxCreditMember" abstract="true" name="NewMarketsTaxCreditMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_EquityMethodInvestmentQualifiedAffordableHousingProjectInvestments" abstract="false" name="EquityMethodInvestmentQualifiedAffordableHousingProjectInvestments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_InvestmentsInQualifiedAffordableHousingProjects" abstract="false" name="InvestmentsInQualifiedAffordableHousingProjects" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_AmortizationMethodQualifiedAffordableHousingProjectInvestmentsCommitment" abstract="false" name="AmortizationMethodQualifiedAffordableHousingProjectInvestmentsCommitment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_EquityMethodQualifiedAffordableHousingProjectInvestmentsCommitment" abstract="false" name="EquityMethodQualifiedAffordableHousingProjectInvestmentsCommitment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_AdvancesFromFederalHomeLoanBanksFairValueHedgeBasisAdjustmentsAndUnamortizedPrepaymentFees" abstract="false" name="AdvancesFromFederalHomeLoanBanksFairValueHedgeBasisAdjustmentsAndUnamortizedPrepaymentFees" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_AdvancesFromFederalHomeLoanBanksModificationsUnamortizedPrepaymentFees" abstract="false" name="AdvancesFromFederalHomeLoanBanksModificationsUnamortizedPrepaymentFees" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_FederalHomeLoanBankAdvanceMaturityAfterYearFour" abstract="false" name="FederalHomeLoanBankAdvanceMaturityAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_OldNationalBankMember" abstract="true" name="OldNationalBankMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_SubordinatedDebenturesDueSeptember2026Member" abstract="true" name="SubordinatedDebenturesDueSeptember2026Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="onb_SubordinatedDebenturesDueJune2030Member" abstract="true" name="SubordinatedDebenturesDueJune2030Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="onb_OtherBasisAdjustments" abstract="false" name="OtherBasisAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_DerivativeInstrumentsCollateralizedPositionAmount" abstract="false" name="DerivativeInstrumentsCollateralizedPositionAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_LongTermDebtMaturityAfterYearFour" abstract="false" name="LongTermDebtMaturityAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNetAndOtherBasisAdjustments" abstract="false" name="DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNetAndOtherBasisAdjustments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_TrustPreferredSecuritiesMember" abstract="true" name="TrustPreferredSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_BridgeviewCapitalTrustIMember" abstract="true" name="BridgeviewCapitalTrustIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_BridgeviewCapitalTrustIIMember" abstract="true" name="BridgeviewCapitalTrustIIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_FirstMidwestCapitalTrustIMember" abstract="true" name="FirstMidwestCapitalTrustIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_StJosephCapitalTrustIIMember" abstract="true" name="StJosephCapitalTrustIIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_NorthernStatesStatutoryTrustIMember" abstract="true" name="NorthernStatesStatutoryTrustIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_AnchorCapitalTrustIIIMember" abstract="true" name="AnchorCapitalTrustIIIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_GreatLakesStatutoryTrustIIMember" abstract="true" name="GreatLakesStatutoryTrustIIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_HomeFederalStatutoryTrustIMember" abstract="true" name="HomeFederalStatutoryTrustIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_MonroeBancorpCapitalTrustIMember" abstract="true" name="MonroeBancorpCapitalTrustIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_TowerCapitalTrustThreeMember" abstract="true" name="TowerCapitalTrustThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_MonroeBancorpStatutoryTrustIIMember" abstract="true" name="MonroeBancorpStatutoryTrustIIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_GreatLakesStatutoryTrustIIIMember" abstract="true" name="GreatLakesStatutoryTrustIIIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_AccumulatedUnrealizedGainsLossesOnHeldToMaturitySecuritiesParentMember" abstract="true" name="AccumulatedUnrealizedGainsLossesOnHeldToMaturitySecuritiesParentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_IncomeTaxReconciliationTaxExemptInterest" abstract="false" name="IncomeTaxReconciliationTaxExemptInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_IncomeTaxReconciliationNonDeductibleExpenseInterestDisallowance" abstract="false" name="IncomeTaxReconciliationNonDeductibleExpenseInterestDisallowance" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_EffectiveIncomeTaxRateReconciliationTaxExemptIncomeLifeInsuranceAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationTaxExemptIncomeLifeInsuranceAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_EffectiveIncomeTaxRateReconciliationOfficerCompensationLimitationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationOfficerCompensationLimitationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_EffectiveIncomeTaxRateReconciliationNonDeductibleFDICPremiumsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNonDeductibleFDICPremiumsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_IncomeTaxesTable" abstract="true" name="IncomeTaxesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="onb_IncomeTaxesLineItems" abstract="true" name="IncomeTaxesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="onb_VariableInterestRateSwapBorrowingsMember" abstract="true" name="VariableInterestRateSwapBorrowingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_VariableInterestRateSwapsCollarsAndFloorsMember" abstract="true" name="VariableInterestRateSwapsCollarsAndFloorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_VariableInterestRateSwapAvailableForSaleInvestmentSecuritiesMember" abstract="true" name="VariableInterestRateSwapAvailableForSaleInvestmentSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_ForwardMortgageLoanContractsMember" abstract="true" name="ForwardMortgageLoanContractsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="onb_ForwardCommitmentsMember" abstract="true" name="ForwardCommitmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_CustomerAndOffsettingCounterpartyDerivativeInstrumentsMember" abstract="true" name="CustomerAndOffsettingCounterpartyDerivativeInstrumentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="onb_PercentageOfPeriodicChangesInFairValueQualifiesForHedgeAccounting" abstract="false" name="PercentageOfPeriodicChangesInFairValueQualifiesForHedgeAccounting" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="onb_InterestRateCashFlowHedgeGainLossToBeReclassifiedToInterestIncomeDuringNext12MonthsNet" abstract="false" name="InterestRateCashFlowHedgeGainLossToBeReclassifiedToInterestIncomeDuringNext12MonthsNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_InterestRateCashFlowHedgeGainLossToBeReclassifiedToInterestExpenseDuringNext12MonthsNet" abstract="false" name="InterestRateCashFlowHedgeGainLossToBeReclassifiedToInterestExpenseDuringNext12MonthsNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_CustomerDerivativeInstrumentMember" abstract="true" name="CustomerDerivativeInstrumentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_OffsettingCounterPartyDerivativeInstrumentMember" abstract="true" name="OffsettingCounterPartyDerivativeInstrumentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_CustomerForeignExchangeForwardMember" abstract="true" name="CustomerForeignExchangeForwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_CounterpartyForeignExchangeForwardMember" abstract="true" name="CounterpartyForeignExchangeForwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_MortgageContractMember" abstract="true" name="MortgageContractMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_TermOfStandbyLettersOfCredit" abstract="false" name="TermOfStandbyLettersOfCredit" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="onb_PercentOfUnfundedLoanCommitmentsWithFixedRates" abstract="false" name="PercentOfUnfundedLoanCommitmentsWithFixedRates" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="onb_LoanCommitmentsFloatingInterestRateMinimum" abstract="false" name="LoanCommitmentsFloatingInterestRateMinimum" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="onb_LoanCommitmentsFloatingInterestRateMaximum" abstract="false" name="LoanCommitmentsFloatingInterestRateMaximum" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="onb_AllowanceForUnfundedLoanCommitments" abstract="false" name="AllowanceForUnfundedLoanCommitments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_LoanCommitments" abstract="false" name="LoanCommitments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_NotionalAmountOfStandbyLettersOfCredit" abstract="false" name="NotionalAmountOfStandbyLettersOfCredit" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_CancellableLoanCommitments" abstract="false" name="CancellableLoanCommitments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_CarryingValueOfLetterOfCredit" abstract="false" name="CarryingValueOfLetterOfCredit" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_CommercialRealEstateForeclosedAssetsMember" abstract="true" name="CommercialRealEstateForeclosedAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_ResidentialForeclosedAssetsMember" abstract="true" name="ResidentialForeclosedAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_ImpairedCommercialAndCommercialRealEstateLoansMember" abstract="true" name="ImpairedCommercialAndCommercialRealEstateLoansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_PrincipalAmountOfCommercialAndCommercialRealEstateLoans" abstract="false" name="PrincipalAmountOfCommercialAndCommercialRealEstateLoans" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_OtherRealEstateOwnedIncludingRepossessedProperty" abstract="false" name="OtherRealEstateOwnedIncludingRepossessedProperty" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_OtherRealEstateOwnedPropertyWriteDown" abstract="false" name="OtherRealEstateOwnedPropertyWriteDown" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="onb_PastDuePeriodOfMortgageLoansHeldForSale" abstract="false" name="PastDuePeriodOfMortgageLoansHeldForSale" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="onb_CollateralDependentImpairedLoansMember" abstract="true" name="CollateralDependentImpairedLoansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_ForeclosedAssetsMember" abstract="true" name="ForeclosedAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_LoansHeldForSaleMember" abstract="true" name="LoansHeldForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="onb_CheckingNowSavingsAndMoneyMarketInterestbearingDeposits" abstract="false" name="CheckingNowSavingsAndMoneyMarketInterestbearingDeposits" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
