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Insider Trading Arrangements
 3 Months Ended
Mar. 31, 2025
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Trading Arrangements, by Individual  
Material Terms of Trading Arrangement

During the quarterly period ended March 31, 2025, the following directors and officers of the Company adopted Rule 10b5-1 trading arrangements that are each intended to satisfy the affirmative defense of Rule 10b5-1(c) promulgated under the Exchange Act. The details of these arrangements are as follows:

On February 28, 2025, Steve Kelsey, M.D., FRCP, FRCPath, President, Research and Development, adopted a Rule 10b5-1 trading plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) promulgated under the Exchange Act, which provides for the potential exercise and sale of up to 150,000 shares of our common stock subject to a stock option held by Dr. Kelsey. The trading plan will terminate at the earlier of the execution of all trading orders pursuant to the plan and October 31, 2025.

On March 7, 2025, Margaret Horn, Chief Operating Officer, adopted a Rule 10b5-1 trading plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) promulgated under the Exchange Act, which provides for the potential exercise and sale of up to 75,000 shares of our common stock subject to a stock option held by Ms. Horn. The trading plan will terminate at the earlier of the execution of all trading orders pursuant to the plan and June 6, 2026.

On March 13, 2025, Jeff Cislini, Senior Vice President, General Counsel and Secretary, adopted a Rule 10b5-1 trading plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) promulgated under the Exchange Act, which provides for (i) the potential exercise and sale of up to 17,388 shares of our common stock subject to stock options held by Mr. Cislini and (ii) the potential sale of shares of our common stock issued upon the settlement of 12,295 restricted stock units, less the number of shares sold to cover tax withholding obligations in connection with the vesting and settlement of such restricted stock units. The trading plan will terminate at the earlier of the execution of all trading orders pursuant to the plan and June 15, 2026.
Steve Kelsey [Member]  
Trading Arrangements, by Individual  
Name Steve Kelsey
Title M.D., FRCP, FRCPath, President, Research and Development
Rule 10b5-1 Arrangement Adopted true
Adoption Date February 28, 2025
Expiration Date October 31, 2025
Arrangement Duration 245 days
Aggregate Available 150,000
Margaret Horn [Member]  
Trading Arrangements, by Individual  
Name Margaret Horn
Title Chief Operating Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date March 7, 2025
Expiration Date June 6, 2026
Arrangement Duration 456 days
Aggregate Available 75,000
Jeff Cislini [Member]  
Trading Arrangements, by Individual  
Name Jeff Cislini
Title Senior Vice President, General Counsel and Secretary
Rule 10b5-1 Arrangement Adopted true
Adoption Date March 13, 2025
Expiration Date June 15, 2026
Arrangement Duration 459 days
Aggregate Available 17,388