<SEC-DOCUMENT>0001684907-23-000001.txt : 20230123
<SEC-HEADER>0001684907-23-000001.hdr.sgml : 20230123
<ACCEPTANCE-DATETIME>20230123164340
ACCESSION NUMBER:		0001684907-23-000001
CONFORMED SUBMISSION TYPE:	5
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20221231
FILED AS OF DATE:		20230123
DATE AS OF CHANGE:		20230123

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Shnayder Boris
		CENTRAL INDEX KEY:			0001684907

	FILING VALUES:
		FORM TYPE:		5
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35418
		FILM NUMBER:		23544961

	MAIL ADDRESS:	
		STREET 1:		41 UNIVERSITY DRIVE SUITE 202
		CITY:			NEWTOWN
		STATE:			PA
		ZIP:			18940

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EPAM Systems, Inc.
		CENTRAL INDEX KEY:			0001352010
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMPUTER PROGRAMMING SERVICES [7371]
		IRS NUMBER:				223536104
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		41 UNIVERSITY DRIVE
		STREET 2:		SUITE 202
		CITY:			NEWTOWN
		STATE:			PA
		ZIP:			18940
		BUSINESS PHONE:		(267) 759-9000

	MAIL ADDRESS:	
		STREET 1:		41 UNIVERSITY DRIVE
		STREET 2:		SUITE 202
		CITY:			NEWTOWN
		STATE:			PA
		ZIP:			18940

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EPAM SYSTEMS INC
		DATE OF NAME CHANGE:	20060202
</SEC-HEADER>
<DOCUMENT>
<TYPE>5
<SEQUENCE>1
<FILENAME>wf-form5_167451020642188.xml
<DESCRIPTION>FORM 5
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>5</documentType>

    <periodOfReport>2022-12-31</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <form3HoldingsReported>0</form3HoldingsReported>

    <form4TransactionsReported>0</form4TransactionsReported>

    <issuer>
        <issuerCik>0001352010</issuerCik>
        <issuerName>EPAM Systems, Inc.</issuerName>
        <issuerTradingSymbol>EPAM</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001684907</rptOwnerCik>
            <rptOwnerName>Shnayder Boris</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EPAM SYSTEMS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>41 UNIVERSITY DRIVE SUITE 202</rptOwnerStreet2>
            <rptOwnerCity>NEWTOWN</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>18940</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>SVP/Co-Head of Global Business</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>EPAM Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-10-31</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>5</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>31</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>245.23</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>7124</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The number of shares in column 4 also includes a de minimis adjustment of 0.417 shares due to the rounding of fractional shares.</footnote>
        <footnote id="F2">The reporting person is voluntarily reporting the acquisition of the Issuer's Common Stock pursuant to the EPAM Systems, Inc. 2021 Employee Stock Purchase Plan (the &quot;ESPP&quot;), for the ESPP purchase period of May 1, 2022 through October 31, 2022 (the &quot;Purchase Period&quot;). This transaction is also exempt from Rule 16b-3(c). In accordance with the ESPP, these shares were purchased at the lesser of (i) 85% of the fair market value of such shares of Common Stock on the first trading day of the Purchase Period and (ii) 85% of the fair market value of such shares of Common Stock on the last day of the Purchase Period.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Kate Pytlewski as Attorney-in-Fact</signatureName>
        <signatureDate>2023-01-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
