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Income Taxes - Components Deferred Taxes (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
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Income Tax Disclosure [Abstract] |  |
Net operating loss carryforwards | $ 32,887 | $ 42,182
Deferred revenue | 837 | 909
Research and development and orphan drug credits | 96,133 | 109,041
Share-based compensation | 6,353 | 1,814
ASC 842 lease liability | 2,480 | 600
Capitalized research expense | 10,168 | 0
Transaction related expense | 2,354 | 0
Inventory related reserves | 18,395 | 0
Interest expense limitation | 0 | 0
Other, net | 3,054 | 3,449
Deferred Tax Assets, Gross | 172,661 | 157,995
Valuation allowance for deferred tax assets | (707) | (500)
Deferred tax assets, net of valuation allowance | 171,954 | 157,495
Non-deductible book amortization | (115,578) |
Depreciation | (2,559) | (1,185)
Convertible note | 0 | (17)
ASC 842 right of use asset | (9,061) | (426)
Other, net | (330) | (433)
Total deferred tax liabilities | (127,528) | (2,061)
Net deferred tax asset | $ 44,426 | $ 155,434

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