Certain Balance Sheet Items

12 Months Ended

Dec. 31, 2022

Balance Sheet Related Disclosures [Abstract]

Accounts receivable consisted of the following (in thousands):


	December 31, 2022		December 31, 2021
Accounts receivable from product sales to partners	$	62,979	$	18,504
Accounts receivable from revenues under collaborative agreements	18,776		5,422
Accounts receivable from royalty payments	100,900		63,555
Accounts receivable from other product sales	6,229		4,634

Contract assets	44,102		—
Subtotal	$	232,986	$	92,115
Allowance for distribution fees and discounts	(1,914)		(1,140)
Total accounts receivable	$	231,072	$	90,975

Inventories consisted of the following (in thousands):


	December 31, 2022		December 31, 2021
Raw materials	$	13,792	$	10,672
Work-in-process	40,361		17,451
Finished goods	45,970		25,785
Total inventories	$	100,123	$	53,908

Prepaid expenses and other assets consisted of the following (in thousands):


	December 31, 2022		December 31, 2021
Prepaid manufacturing expenses	$	51,694	$	47,991

Other prepaid expenses	4,647		3,809
Other assets	14,984		2,096
Total prepaid expenses and other assets	$	71,325	$	53,896
Less long-term portion	(26,301)		(13,414)
Total prepaid expenses and other assets, current	$	45,024	$	40,482

Prepaid manufacturing expenses include raw materials, slot reservation fees and other amounts paid to contract manufacturing organizations. Such amounts are reclassified to work-in-process inventory as materials are used or the contract manufacturing organization services are complete.

Property and equipment, net consisted of the following (in thousands):


	December 31, 2022		December 31, 2021
Research equipment	$	7,380	$	7,174
Manufacturing equipment	27,893		5,719
Computer and office equipment	7,855		5,370
Leasehold improvements	6,729		1,628
Subtotal	$	49,857	$	19,891
Accumulated depreciation and amortization	(14,756)		(13,100)
Subtotal	$	35,101	$	6,791
Right of use of assets	40,469		2,003
Property and equipment, net	$	75,570	$	8,794

Depreciation and amortization expense was approximately $6.5 million, $3.0 million, and $3.3 million, inclusive of ROU asset amortization of $3.0 million, $1.6 million and $1.7 million for the years ended December 31, 2022, 2021 and 2020, respectively.

Accrued expenses consisted of the following (in thousands):


	December 31, 2022		December 31, 2021

Accrued compensation and payroll taxes	$	19,939	$	9,858
Accrued outsourced manufacturing expenses	12,190		6,514
Income taxes payable	—		1,439
Product returns and sales allowance	30,261		706
Other accrued expenses	29,771		3,648
Lease liability	34,788		2,820
Total accrued expenses	$	126,949	$	24,985
Less long-term portion	(30,433)		(544)
Total accrued expenses, current	$	96,516	$	24,441

Expense associated with the accretion of the lease liabilities was approximately $0.5 million, $0.3 million and $0.5 million for the twelve months ended December 31, 2022, 2021 and 2020, respectively. Total lease expense for the twelve months ended December 31, 2022, 2021 and 2020 was $3.3 million, $1.9 million and $2.2 million, respectively.

Cash paid for amounts related to leases for the twelve months ended December 31, 2022, 2021 and 2020 was $4.2 million, $2.7 million and $3.2 million, respectively.