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Share-based Compensation (Tables)
12 Months Ended
Dec. 31, 2022
Share-based Payment Arrangement [Abstract]  
Share-based Compensation Expense Related To Share-based Payment Awards Excluding Acceleration of Antares Equity Awards
Total share-based compensation expense related to share-based awards excluding the acceleration of Antares equity awards was comprised of the following (in thousands):
Year Ended December 31,
 202220212020
Research and development$9,903 $6,992 $5,484 
Selling, general and administrative14,494 13,828 11,720 
Share-based compensation expense$24,397 $20,820 $17,204 
Share-based Compensation Expense By Type
Share-based compensation expense by type of share-based award (in thousands):
Year Ended December 31,
 202220212020
Stock options$10,973 $10,252 $8,955 
RSAs, RSUs, PSUs and ESPP13,424 10,568 8,249 
$24,397 $20,820 $17,204 
Total Unrecognized Estimated Compensation Cost By Type
Total unrecognized estimated compensation cost by type of award and the weighted-average remaining requisite service period over which such expense is expected to be recognized (in thousands, unless otherwise noted):
December 31, 2022
 Unrecognized
Expense
Remaining
Weighted-Average
Recognition Period
(years)
Stock options$26,730 2.66
RSUs$26,488 2.32
PSUs$3,986 1.91
ESPP$247 0.45
Summary of Stock Option Award Activity
A summary of our stock option award activity as of and for the year ended December 31, 2022 is as follows: 
Shares
Underlying
Stock Options
Weighted
Average Exercise
Price per Share
Weighted
Average
Remaining
Contractual
Term (years)
Aggregate
Intrinsic
Value (in Millions)
Outstanding at December 31, 2021
4,965,374 $20.76
Granted1,773,912 $37.25
Exercised(789,870)$19.40
Canceled/forfeited(581,191)$33.87
Outstanding at December 31, 2022
5,368,225 $24.996.48$171.3
Vested and expected to vest at December 31, 2022
5,368,225 $24.996.48$171.3
Exercisable at December 31, 2022
3,176,691 $17.224.92$126.0
Schedule of Valuation Assumptions The assumptions used in the Black-Scholes model were as follows:
Year Ended December 31,
 202220212020
Expected volatility
39.91-50.81%
41.01-46.45%
47.57-51.82%
Average expected term (in years)4.74.75.1
Risk-free interest rate
1.37-4.27%
0.36-1.20%
0.22-1.67%
Expected dividend yield— — — 
Summary of RSU Activity
The following table summarizes our RSU activity during the year ended December 31, 2022:
Number of
Shares
Weighted
Average
Grant Date
Fair Value
Weighted
Average
Remaining
Contractual
Term (yrs)
Aggregate
Intrinsic
Value (in Millions)
Outstanding at December 31, 2021
858,742 $29.54
Granted706,096 $39.18
Vested(320,767)$26.68
Forfeited(204,690)$35.69
Outstanding at December 31, 2022
1,039,381 $35.761.25$59.1
Schedule of PSU Activity
The following table summarizes our PSU activity during the year ended December 31, 2022:
Number of
Shares
Weighted
Average
Grant Date
Fair Value
Outstanding at December 31, 2021
69,382 $40.66
Granted129,773 $41.42
Vested(2,565)$63.41
Forfeited(53,746)$27.20
Outstanding at December 31, 2022
142,844 $46.01