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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Revenues:      
Total revenues $ 660,116 $ 443,310 $ 267,594
Operating expenses:      
Cost of sales 139,304 81,413 43,367
Amortization of intangible assets 43,148 0 0
Research and development 66,607 35,672 34,236
Selling, general and administrative 143,526 50,323 45,736
Total operating expenses 392,585 167,408 123,339
Operating income 267,531 275,902 144,255
Other income (expense):      
Investment and other income, net 1,046 1,102 5,425
Induced conversion expense related to convertible notes (2,712) (20,960) 0
Interest expense (16,947) (7,526) (20,378)
Net income before income taxes 248,918 248,518 129,302
Income tax expense (benefit) 46,789 (154,192) 217
Net income $ 202,129 $ 402,710 $ 129,085
Net income per share:      
Basic (USD per share) $ 1.48 $ 2.86 $ 0.95
Diluted (USD per share) $ 1.44 $ 2.74 $ 0.91
Shares used in computing net income per share:      
Basic (shares) 136,844 140,646 136,206
Diluted (shares) 140,608 146,796 141,463
Royalties      
Revenues:      
Total revenues $ 360,475 $ 203,900 $ 88,596
Product sales, net      
Revenues:      
Total revenues 191,030 104,224 55,987
Revenues under collaborative agreements      
Revenues:      
Total revenues $ 108,611 $ 135,186 $ 123,011