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Income Taxes - Components of Deferred Tax Assets (Liabilities) (Details) - USD ($) $ in Thousands | Dec. 31, 2024 | Dec. 31, 2023
--- | --- | ---
Deferred tax assets |  |
Net operating loss carryforwards | $ 20,736 | $ 32,753
Research and development and orphan drug credits | 17,868 | 38,192
Share-based compensation | 6,567 | 5,024
ASC 842 lease liability | 7,126 | 7,258
Capitalized research expense | 30,253 | 19,543
Inventory related reserves | 19,867 | 13,561
Other, net | 4,206 | 6,746
Total deferred tax assets | 106,623 | 123,077
Valuation allowance for deferred tax assets | (2,363) | (2,588)
Deferred tax assets, net of valuation allowance | 104,260 | 120,489
Deferred tax liabilities |  |
Non-deductible book amortization | (89,247) | (103,492)
ASC 842 right of use asset | (7,882) | (8,259)
Other, net | (3,276) | (4,352)
Total deferred tax liabilities | (100,405) | (116,103)
Net deferred tax asset | $ 3,855 | $ 4,386

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