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Income Taxes - Components of Deferred Tax Assets and Deferred Tax Liabilities (Details) - USD ($) $ in Millions | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 264.8 | $ 119.6
Research credit carryforwards | 157.3 | 67.9
Stock-based compensation | 11.1 | 20.0
Accruals and reserves | 42.0 | 34.0
Fixed assets and intangible assets | 0.7 | 0.0
Other | 1.1 | 0.0
Gross deferred tax assets | 477.0 | 241.5
Valuation allowance | (476.0) | (233.7)
Total deferred tax assets, net of valuation allowance | 1.0 | 7.8
Deferred tax liabilities: |  |
Fixed assets and intangible assets | 0.0 | 6.6
Other | 0.0 | 0.4
Total deferred tax liability | 0.0 | 7.0
Net deferred tax assets | $ 1.0 | $ 0.8

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