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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Tax Disclosure [Abstract]

Schedule of Income before Income Tax, Domestic and Foreign

For the years ended December 31, 2018, 2017, and 2016 the Company’s income (loss) from continuing operations before provision for income taxes was as follows:

		Year ended December 31,
		2018				2017				2016
Domestic		$	(497.1	)		$	(76.9	)		$	(94.4	)
Foreign		17.0				(34.6		)		(110.6		)
Loss before income taxes		$	(480.1	)		$	(111.5	)		$	(205.0	)

Schedule of Components of Income Tax Expense (Benefit)

The components of the provision for income taxes in the years ended December 31, 2018, 2017, and 2016 were as follows:

		Year ended December 31,
		2018				2017				2016
Current:
Federal		$	(0.1	)		$	0.1			$	(1.5	)
State		(0.2		)		(0.3		)		(0.6		)
Foreign		(4.6		)		(2.3		)		(2.9		)
Deferred:		—
Federal		—				1.4				—
State		—				—				—
Foreign		0.1				0.9				(0.2		)
Provision for income taxes		$	(4.8	)		$	(0.2	)		$	(5.2	)

Schedule of Effective Income Tax Rate Reconciliation

Income tax benefit attributable to loss from continuing operations differed from the amounts computed by applying the statutory U.S. federal income tax rate of 21% for 2018 and 34% for 2017 and 2016 to pretax loss from continuing operations as a result of the following:

		Year ended December 31,
		2018				2017				2016
Tax benefit at federal statutory rate		$	100.8			$	37.9			$	69.7
State taxes, net of federal benefit		10.7				1.7				2.2
Foreign rate differential		1.8				(12.3		)		(38.8		)
Research and other credits		86.5				25.4				12.6
Permanent differences		(18.4		)		(9.0		)		(3.5		)
Tax Cuts and Jobs Act impact		—				(61.7		)		—
Change in valuation allowance		(240.7		)		38.9				(40.7		)
Stock-based compensation		57.3				(20.1		)		(4.8		)
Other nondeductible items		(2.8		)		(1.0		)		(1.9		)
Provision for income taxes		$	(4.8	)		$	(0.2	)		$	(5.2	)

Schedule of Deferred Tax Assets and Liabilities

The significant components of the Company’s deferred tax assets and liabilities as of December 31, 2018 and 2017 were as follows:

		As of December 31,
		2018				2017
Deferred tax assets:
Net operating loss carryforwards		$	264.8			$	119.6
Research credit carryforwards		157.3				67.9
Stock-based compensation		11.1				20.0
Accruals and reserves		42.0				34.0
Fixed assets and intangible assets		0.7				—
Other		1.1				—
Gross deferred tax assets		477.0				241.5
Valuation allowance		(476.0		)		(233.7		)
Total deferred tax assets, net of valuation allowance		1.0				7.8
Deferred tax liabilities:
Fixed assets and intangible assets		—				6.6
Other		—				0.4
Total deferred tax liability		—				7.0
Net deferred tax assets		$	1.0			$	0.8

Schedule of Unrecognized Tax Benefits Roll Forward

A reconciliation of the beginning and ending amount of unrecognized tax benefit is as follows:

		Year ended December 31,
		2018				2017				2016
Balance of gross unrecognized tax benefits at the beginning of the fiscal year		$	25.6			$	15.7			$	7.9
Gross increases related to prior period tax positions		1.1				—				2.2
Gross increases related to current period tax positions		33.1				9.9				5.6
Balance of gross unrecognized tax benefits at the end of the fiscal year		$	59.8			$	25.6			$	15.7

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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Tabular disclosure of the change in unrecognized tax benefits.

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