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Income Taxes - Narrative (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Operating Loss Carryforwards [Line Items]        
Federal income tax rates 21.00% 34.00% 34.00%  
Operating loss carryforwards, expiring in future $ 307,400,000      
Operating loss carryforwards, carryforward indefinitely 616,200,000      
Unrecognized tax benefits 59,800,000 $ 25,600,000 $ 15,700,000 $ 7,900,000
Unrecognized tax benefits that would impact effective tax rate 4,500,000      
Unrecognized tax benefits that would impact effective tax rate, adjustment to deferred tax assets and valuation allowance 55,300,000      
Penalties and interest accrued 1,300,000      
Penalties and interest expense 700,000 200,000 $ 400,000  
Undistributed earnings of foreign subsidiaries 0      
Estimated reduction in deferred tax assets due to remeasurement   63,100,000    
Estimated tax benefit from repealed corporate AMT   1,400,000    
Estimated transition tax inclusion   $ 0    
Domestic        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 923,600,000      
Domestic | Research Tax Credit Carryforward        
Operating Loss Carryforwards [Line Items]        
Tax credit carryforward, amount 145,000,000      
Tax credit carryforward, valuation allowance 36,100,000      
State        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 403,500,000      
State | Research Tax Credit Carryforward        
Operating Loss Carryforwards [Line Items]        
Tax credit carryforward, amount 76,800,000      
Tax credit carryforward, valuation allowance 19,100,000      
State | State Enterprise Tax Credit Carryforward        
Operating Loss Carryforwards [Line Items]        
Tax credit carryforward, amount 3,700,000      
Foreign        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 288,000,000      
Operating loss carryforwards, carryforward indefinitely 265,100,000      
Operating loss carryforwards, acquired $ 22,900,000