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Income Taxes - Income Tax Rate Reconciliation (Details) - USD ($) $ in Millions		12 Months Ended
		Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
Provision for income taxes at federal statutory rate		$ (116.4)	$ (40.5)	$ (62.8)
State taxes, net of federal benefit		(14.6)	(4.9)	(5.5)
Foreign rate differential		(20.9)	(34.0)	0.9
Research and other credits		60.9	45.3	38.1
Non-deductible compensation		(7.4)	(3.4)	(6.2)
Permanent differences		(0.8)	(1.8)	(0.8)
Change in valuation allowance		(2.4)	409.9	51.4
Stock-based compensation		2.7	(4.3)	23.5
Other non-deductible items		(1.9)	(5.8)	(2.1)
(Provision for) benefit from income taxes	[1]	$ (100.8)	$ 360.5	$ 36.5
[1] Results of Operations for the year ended December 31, 2022 includes a one-time benefit from income taxes of $420.2 million due to the release of a valuation allowance on the U.S. federal and certain state deferred tax assets. Results of Operations for the year ended December 31, 2021 includes a one-time benefit from income taxes of $38.1 million from the release of a valuation allowance on the Irish deferred tax assets.

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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