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Income Taxes - Income Tax Rate Reconciliation (Details) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Income Tax Disclosure [Abstract] |  |  |  |
Provision for income taxes at federal statutory rate |  | $ (107.1) | $ (116.4) | $ (40.5)
State taxes, net of federal benefit |  | (10.5) | (14.6) | (4.9)
Foreign rate differential |  | 2.3 | (20.9) | (34.0)
Research and other credits |  | 53.2 | 60.9 | 45.3
Non-deductible compensation |  | (4.7) | (7.4) | (3.4)
Permanent differences |  | (1.4) | (0.8) | (1.8)
Change in valuation allowance |  | (5.4) | (2.4) | 409.9
Stock-based compensation |  | 8.8 | 2.7 | (4.3)
Changes in Unrecognized Tax Benefits |  | 7.3 | (1.9) | (5.8)
(Provision for) benefit from income taxes | [1] | $ (57.5) | $ (100.8) | $ 360.5
[1] | Results of Operations for the year ended December 31, 2022 includes a one-time benefit from income taxes of $420.2 million due to the release of a valuation allowance on the U.S. federal and certain state deferred tax assets.

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