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Income Taxes - Components of Deferred Tax Assets and Deferred Tax Liabilities (Details) - USD ($) $ in Millions | Dec. 31, 2024 | Dec. 31, 2023
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Deferred tax assets: |  |
Net operating loss carryforwards | $ 20.7 | $ 18.9
Research credit carryforwards | 194.9 | 217.1
Stock-based compensation | 25.7 | 24.8
Accruals and reserves | 25.9 | 29.0
Lease liability | 60.4 | 72.5
Convertible senior notes | 26.5 | 37.1
Capitalized research expenditures | 289.3 | 233.3
Other | 0.6 | 0.2
Gross deferred tax assets | 644.0 | 632.9
Valuation allowance | (122.8) | (116.3)
Total deferred tax assets, net of valuation allowance | 521.2 | 516.6
Deferred tax liabilities: |  |
Fixed assets and intangible assets | 25.9 | 21.8
Right-of-use assets | 24.7 | 31.4
Other | 3.9 | 3.0
Total deferred tax liability | 54.5 | 56.2
Net deferred tax assets | $ 466.7 | $ 460.4

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