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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2024
Income Tax Disclosure [Abstract]  
Schedule of Income before Income Tax, Domestic and Foreign
For the years ended December 31, 2024, 2023, and 2022, the Company’s income from continuing operations before provision for income taxes was as follows:

 Year Ended
December 31,
 202420232022
Domestic$280.4 $385.8 $37.8 
Foreign229.4 168.6 154.9 
Income before income taxes$509.8 $554.4 $192.7 
Schedule of Components of the (Provision for) Benefit from Income Taxes
The components of the (provision for) benefit from income taxes in the years ended December 31, 2024, 2023, and 2022, were as follows:

 Year Ended
December 31,
 202420232022
Current:
Federal$(21.7)$(37.6)$(13.2)
State(11.2)(14.6)(15.3)
Foreign(30.9)(10.7)(7.5)
Deferred:
Federal2.6 (23.0)386.7 
State4.5 2.7 30.0 
Foreign(0.8)(17.6)(20.2)
(Provision for) benefit from income taxes$(57.5)$(100.8)$360.5 
Schedule of Effective Income Tax Rate Reconciliation
A reconciliation of income taxes at the statutory federal income tax rate to the benefit from (provision for) income taxes included in the accompanying consolidated statements of operations is as follows:

 Year Ended
December 31,
 202420232022
Provision for income taxes at federal statutory rate$(107.1)$(116.4)$(40.5)
State taxes, net of federal benefit(10.5)(14.6)(4.9)
Foreign rate differential2.3 (20.9)(34.0)
Research and other credits53.2 60.9 45.3 
Non-deductible compensation(4.7)(7.4)(3.4)
Permanent differences(1.4)(0.8)(1.8)
Change in valuation allowance(5.4)(2.4)409.9 
Stock-based compensation8.82.7 (4.3)
Changes in Unrecognized Tax Benefits7.3 (1.9)(5.8)
(Provision for) benefit from income taxes$(57.5)$(100.8)$360.5 
Schedule of Deferred Tax Assets and Liabilities
The significant components of the Company’s deferred tax assets and liabilities as of December 31, 2024 and 2023 were as follows:

 As of December 31,
 20242023
Deferred tax assets:
Net operating loss carryforwards$20.7 $18.9 
Research credit carryforwards194.9 217.1 
Stock-based compensation25.7 24.8 
Accruals and reserves25.9 29.0 
Lease liability60.4 72.5 
Convertible senior notes26.5 37.1 
Capitalized research expenditures289.3 233.3 
Other0.6 0.2 
Gross deferred tax assets644.0 632.9 
Valuation allowance(122.8)(116.3)
Total deferred tax assets, net of valuation allowance521.2 516.6 
Deferred tax liabilities:
Fixed assets and intangible assets25.9 21.8 
Right-of-use assets24.7 31.4 
Other3.9 3.0 
Total deferred tax liability54.5 56.2 
Net deferred tax assets$466.7 $460.4 
Schedule of Unrecognized Tax Benefits Roll Forward
A reconciliation of the beginning and ending amount of unrecognized tax benefit is as follows:

 Year Ended
December 31,
 202420232022
Balance of gross unrecognized tax benefits at the beginning of the fiscal year$149.8 $127.2 $107.3 
Gross increases related to prior period tax positions0.3 3.4 — 
Gross decreases related to prior period tax positions(0.2)(0.7)— 
Gross increases related to current period tax positions20.7 21.1 20.3 
Reductions due to lapse in statute of limitations— (1.2)(0.4)
Reductions due to settlements with taxing authorities(7.9)— — 
Balance of gross unrecognized tax benefits at the end of the fiscal year$162.7 $149.8 $127.2