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Income Taxes - Income Tax Rate Reconciliation (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Income Tax Disclosure [Abstract]      
Provision for income taxes at federal statutory rate $ (107.1) $ (116.4) $ (40.5)
State taxes, net of federal benefit (10.5) (14.6) (4.9)
Foreign rate differential 2.3 (20.9) (34.0)
Research and other credits 53.2 60.9 45.3
Non-deductible compensation (4.7) (7.4) (3.4)
Permanent differences (1.4) (0.8) (1.8)
Change in valuation allowance (5.4) (2.4) 409.9
Stock-based compensation 8.8 2.7 (4.3)
Changes in Unrecognized Tax Benefits 7.3 (1.9) (5.8)
(Provision for) benefit from income taxes [1] $ (57.5) $ (100.8) $ 360.5
[1] Results of Operations for the year ended December 31, 2022 includes a one-time benefit from income taxes of $420.2 million due to the release of a valuation allowance on the U.S. federal and certain state deferred tax assets.