<SEC-DOCUMENT>0000080255-25-000570.txt : 20250814
<SEC-HEADER>0000080255-25-000570.hdr.sgml : 20250814
<ACCEPTANCE-DATETIME>20250814130720
ACCESSION NUMBER:		0000080255-25-000570
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250814
DATE AS OF CHANGE:		20250814

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIO-TECHNE Corp
		CENTRAL INDEX KEY:			0000842023
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				411427402
		STATE OF INCORPORATION:			MN
		FISCAL YEAR END:			0630

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-42508
		FILM NUMBER:		251216743

	BUSINESS ADDRESS:	
		STREET 1:		614 MCKINLEY PL N E
		CITY:			MINNEAPOLIS
		STATE:			MN
		ZIP:			55413
		BUSINESS PHONE:		6123798854

	MAIL ADDRESS:	
		STREET 1:		614 MCKINLEY PLACE NE
		CITY:			MINNEAPOLIS
		STATE:			MN
		ZIP:			55413

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TECHNE CORP /MN/
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PRICE T ROWE ASSOCIATES INC /MD/
		CENTRAL INDEX KEY:			0000080255
		STANDARD INDUSTRIAL CLASSIFICATION:	SECURITY & COMMODITY BROKERS, DEALERS, EXCHANGES & SERVICES [6200]
		ORGANIZATION NAME:           	09 Crypto Assets
		EIN:				520556948
		STATE OF INCORPORATION:			MD
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		1307 POINT STREET
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21231
		BUSINESS PHONE:		(410)345-2000

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 89000
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21289
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>SCHEDULE 13G/A</submissionType>
        <previousAccessionNumber>0000080255-24-001379</previousAccessionNumber>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0000080255</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>


        </filerInfo>
    </headerData>
    <formData>
        <coverPageHeader>
            <amendmentNo>2</amendmentNo>
            <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
            <eventDateRequiresFilingThisStatement>06/30/2025</eventDateRequiresFilingThisStatement>
            <issuerInfo>
                <issuerCik>0000842023</issuerCik>
                <issuerName>BIO-TECHNE CORP</issuerName>
                <issuerCusip>09073M104</issuerCusip>
                <issuerPrincipalExecutiveOfficeAddress>
                    <ns2:street1>614 MCKINLEY PL N E</ns2:street1>
                    <ns2:city>MINNEAPOLIS</ns2:city>
                    <ns2:stateOrCountry>MN</ns2:stateOrCountry>
                    <ns2:zipCode>55413</ns2:zipCode>
                </issuerPrincipalExecutiveOfficeAddress>
            </issuerInfo>
            <designateRulesPursuantThisScheduleFiled>
                <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
            </designateRulesPursuantThisScheduleFiled>
        </coverPageHeader>
        <coverPageHeaderReportingPersonDetails>

            <reportingPersonName>T. Rowe Price Associates, Inc.</reportingPersonName>
            <citizenshipOrOrganization>MD</citizenshipOrOrganization>
            <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>8375015</soleVotingPower>
                <sharedVotingPower>0</sharedVotingPower>
                <soleDispositivePower>8732036</soleDispositivePower>
                <sharedDispositivePower>0</sharedDispositivePower>
            </reportingPersonBeneficiallyOwnedNumberOfShares>
            <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>8848150</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
            <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
            <classPercent>5.6</classPercent>
            <typeOfReportingPerson>IA</typeOfReportingPerson>
        </coverPageHeaderReportingPersonDetails>
        <items>
            <item1>
                <issuerName>BIO-TECHNE CORP</issuerName>
                <issuerPrincipalExecutiveOfficeAddress>614 MCKINLEY PL N E, MINNEAPOLIS, MN, 55413</issuerPrincipalExecutiveOfficeAddress>
            </item1>
            <item2>
                <filingPersonName>T. Rowe Price Associates, Inc.</filingPersonName>
                <principalBusinessOfficeOrResidenceAddress>1307 Point Street, Baltimore, MD 21231</principalBusinessOfficeOrResidenceAddress>
                <citizenship>Maryland</citizenship>
            </item2>
            <item3>
                <notApplicableFlag>N</notApplicableFlag>
                <typeOfPersonFiling>IA</typeOfPersonFiling>
            </item3>
            <item4>
                <amountBeneficiallyOwned>8848150</amountBeneficiallyOwned>
                <classPercent>5.6</classPercent>
                <numberOfSharesPersonHas>
                    <solePowerOrDirectToVote>8375015</solePowerOrDirectToVote>
                    <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
                    <solePowerOrDirectToDispose>8732036</solePowerOrDirectToDispose>
                    <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
                </numberOfSharesPersonHas>
            </item4>
            <item5>
                <notApplicableFlag>Y</notApplicableFlag>
            </item5>
            <item6>
                <notApplicableFlag>Y</notApplicableFlag>
            </item6>
            <item7>
                <notApplicableFlag>Y</notApplicableFlag>
            </item7>
            <item8>
                <notApplicableFlag>Y</notApplicableFlag>
            </item8>
            <item9>
                <notApplicableFlag>Y</notApplicableFlag>
            </item9>
            <item10>
                <notApplicableFlag>N</notApplicableFlag>
                <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. T. Rowe Price Associates, Inc. hereby declares and affirms that the filing of Schedule 13G shall not be construed as an admission that Price Associates is the beneficial owner of the securities referred to, which beneficial ownership is expressly denied.</certifications>
            </item10>
        </items>
        <signatureInformation>
            <reportingPersonName>T. Rowe Price Associates, Inc.</reportingPersonName>
            <signatureDetails>
                <signature>Ellen York</signature>
                <title>Vice President</title>
                <date>08/14/2025</date>
            </signatureDetails>
        </signatureInformation>
    </formData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
