EXHIBIT 24.1

POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Patrick B. Frost, Phillip D. Green, and Jerry Salinas, and each of them, his or her true and lawful attorneys-in-fact and agents, and with power of substitution and resubstitution, for him/her and in his/her name, place and stead, and in any and all capacities, to sign the Annual Report on Form 10-K of Cullen/Frost Bankers, Inc. for the fiscal year ended December 31, 2020, to sign any and all amendments thereto, and to file such Annual Report and amendments, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as fully to all intents and purposes as he/she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or either of them, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Signature			Title			Date
/s/ PHILLIP D. GREEN			Chairman of the Board, Director and Chief Executive Officer (Principal Executive Officer)			January 27, 2021
Phillip D. Green
/s/ JERRY SALINAS			Group Executive Vice President and Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer)			January 27, 2021
Jerry Salinas
/s/ CARLOS ALVAREZ			Director			January 27, 2021
Carlos Alvarez
/s/ CHRIS AVERY			Director			January 27, 2021
Chris Avery
/s/ ANTHONY R. CHASE			Director			January 27, 2021
Anthony R. Chase
/s/ CYNTHIA COMPARIN			Director			January 27, 2021
Cynthia Comparin
/s/ SAM DAWSON			Director			January 27, 2021
Sam Dawson
/s/ CRAWFORD H. EDWARDS			Director			January 27, 2021
Crawford H. Edwards
/s/ PATRICK B. FROST			Director and President of Frost Bank			January 27, 2021
Patrick B. Frost
/s/ DAVID J. HAEMISEGGER			Director			January 27, 2021
David J. Haemisegger
/s/ KAREN E. JENNINGS			Director			January 27, 2021
Karen E. Jennings
/s/ CHARLES W. MATTHEWS			Director			January 27, 2021
Charles W. Matthews
/s/ IDA CLEMENT STEEN			Director			January 27, 2021
Ida Clement Steen
/s/ GRAHAM WESTON			Director			January 27, 2021
Graham Weston